Chronic glucose-dependent insulinotropic polypeptide receptor (GIPR) agonism desensitizes adipocyte GIPR activity mimicking functional GIPR antagonism

Chronic glucose-dependent insulinotropic polypeptide receptor (GIPR) agonism desensitizes adipocyte GIPR activity mimicking functional GIPR antagonism

Both agonism and antagonism of the glucose-dependent insulinotropic polypeptide receptor (GIPR) lead to weight loss in combination with glucagon-like peptide-1 receptor agonists in preclinical models. Here the authors show that this may be explained by desensitization of GIPR activity by chronic GIP...

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Autores principales: Elizabeth A. Killion, Michelle Chen, James R. Falsey, Glenn Sivits, Todd Hager, Larissa Atangan, Joan Helmering, Jae Lee, Hongyan Li, Bin Wu, Yuan Cheng, Murielle M. Véniant, David J. Lloyd
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/35bda07550384ea78b2522ff1a815550
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spelling oai:doaj.org-article:35bda07550384ea78b2522ff1a8155502021-12-02T18:37:29ZChronic glucose-dependent insulinotropic polypeptide receptor (GIPR) agonism desensitizes adipocyte GIPR activity mimicking functional GIPR antagonism10.1038/s41467-020-18751-82041-1723https://doaj.org/article/35bda07550384ea78b2522ff1a8155502020-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18751-8https://doaj.org/toc/2041-1723Both agonism and antagonism of the glucose-dependent insulinotropic polypeptide receptor (GIPR) lead to weight loss in combination with glucagon-like peptide-1 receptor agonists in preclinical models. Here the authors show that this may be explained by desensitization of GIPR activity by chronic GIPR agonism in vitro and in vivo.Elizabeth A. KillionMichelle ChenJames R. FalseyGlenn SivitsTodd HagerLarissa AtanganJoan HelmeringJae LeeHongyan LiBin WuYuan ChengMurielle M. VéniantDavid J. LloydNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Elizabeth A. Killion
Michelle Chen
James R. Falsey
Glenn Sivits
Todd Hager
Larissa Atangan
Joan Helmering
Jae Lee
Hongyan Li
Bin Wu
Yuan Cheng
Murielle M. Véniant
David J. Lloyd
Chronic glucose-dependent insulinotropic polypeptide receptor (GIPR) agonism desensitizes adipocyte GIPR activity mimicking functional GIPR antagonism
description Both agonism and antagonism of the glucose-dependent insulinotropic polypeptide receptor (GIPR) lead to weight loss in combination with glucagon-like peptide-1 receptor agonists in preclinical models. Here the authors show that this may be explained by desensitization of GIPR activity by chronic GIPR agonism in vitro and in vivo.
format article
author Elizabeth A. Killion
Michelle Chen
James R. Falsey
Glenn Sivits
Todd Hager
Larissa Atangan
Joan Helmering
Jae Lee
Hongyan Li
Bin Wu
Yuan Cheng
Murielle M. Véniant
David J. Lloyd
author_facet Elizabeth A. Killion
Michelle Chen
James R. Falsey
Glenn Sivits
Todd Hager
Larissa Atangan
Joan Helmering
Jae Lee
Hongyan Li
Bin Wu
Yuan Cheng
Murielle M. Véniant
David J. Lloyd
author_sort Elizabeth A. Killion
title Chronic glucose-dependent insulinotropic polypeptide receptor (GIPR) agonism desensitizes adipocyte GIPR activity mimicking functional GIPR antagonism
title_short Chronic glucose-dependent insulinotropic polypeptide receptor (GIPR) agonism desensitizes adipocyte GIPR activity mimicking functional GIPR antagonism
title_full Chronic glucose-dependent insulinotropic polypeptide receptor (GIPR) agonism desensitizes adipocyte GIPR activity mimicking functional GIPR antagonism
title_fullStr Chronic glucose-dependent insulinotropic polypeptide receptor (GIPR) agonism desensitizes adipocyte GIPR activity mimicking functional GIPR antagonism
title_full_unstemmed Chronic glucose-dependent insulinotropic polypeptide receptor (GIPR) agonism desensitizes adipocyte GIPR activity mimicking functional GIPR antagonism
title_sort chronic glucose-dependent insulinotropic polypeptide receptor (gipr) agonism desensitizes adipocyte gipr activity mimicking functional gipr antagonism
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/35bda07550384ea78b2522ff1a815550
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