Gait parameters of Parkinson’s disease compared with healthy controls: a systematic review and meta-analysis

Abstract We systematically reviewed observational and clinical trials (baseline) studies examining differences in gait parameters between Parkinson’s disease (PD) in on-medication state and healthy control. Four electronic databases were searched (November-2018 and updated in October-2020). Independ...

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Autores principales:	Ana Paula Janner Zanardi, Edson Soares da Silva, Rochelle Rocha Costa, Elren Passos-Monteiro, Ivan Oliveira dos Santos, Luiz Fernando Martins Kruel, Leonardo Alexandre Peyré-Tartaruga
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/35bdfea70a65447e8db69f135a18fa76
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spelling	oai:doaj.org-article:35bdfea70a65447e8db69f135a18fa762021-12-02T15:23:02ZGait parameters of Parkinson’s disease compared with healthy controls: a systematic review and meta-analysis10.1038/s41598-020-80768-22045-2322https://doaj.org/article/35bdfea70a65447e8db69f135a18fa762021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-80768-2https://doaj.org/toc/2045-2322Abstract We systematically reviewed observational and clinical trials (baseline) studies examining differences in gait parameters between Parkinson’s disease (PD) in on-medication state and healthy control. Four electronic databases were searched (November-2018 and updated in October-2020). Independent researchers identified studies that evaluated gait parameters measured quantitatively during self-selected walking speed. Risk of bias was assessed using an instrument proposed by Downs and Black (1998). Pooled effects were reported as standardized mean differences and 95% confidence intervals using a random-effects model. A total of 72 studies involving 3027 participants (1510 with PD and 1517 health control) met the inclusion criteria. The self-selected walking speed, stride length, swing time and hip excursion were reduced in people with PD compared with healthy control. Additionally, PD subjects presented higher cadence and double support time. Although with a smaller difference for treadmill, walking speed is reduced both on treadmill (.13 m s−1) and on overground (.17 m s−1) in PD. The self-select walking speed, stride length, cadence, double support, swing time and sagittal hip angle were altered in people with PD compared with healthy control. The precise determination of these modifications will be beneficial in determining which intervention elements are most critical in bringing about positive, clinically meaningful changes in individuals with PD (PROSPERO protocol CRD42018113042).Ana Paula Janner ZanardiEdson Soares da SilvaRochelle Rocha CostaElren Passos-MonteiroIvan Oliveira dos SantosLuiz Fernando Martins KruelLeonardo Alexandre Peyré-TartarugaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ana Paula Janner Zanardi Edson Soares da Silva Rochelle Rocha Costa Elren Passos-Monteiro Ivan Oliveira dos Santos Luiz Fernando Martins Kruel Leonardo Alexandre Peyré-Tartaruga Gait parameters of Parkinson’s disease compared with healthy controls: a systematic review and meta-analysis
description	Abstract We systematically reviewed observational and clinical trials (baseline) studies examining differences in gait parameters between Parkinson’s disease (PD) in on-medication state and healthy control. Four electronic databases were searched (November-2018 and updated in October-2020). Independent researchers identified studies that evaluated gait parameters measured quantitatively during self-selected walking speed. Risk of bias was assessed using an instrument proposed by Downs and Black (1998). Pooled effects were reported as standardized mean differences and 95% confidence intervals using a random-effects model. A total of 72 studies involving 3027 participants (1510 with PD and 1517 health control) met the inclusion criteria. The self-selected walking speed, stride length, swing time and hip excursion were reduced in people with PD compared with healthy control. Additionally, PD subjects presented higher cadence and double support time. Although with a smaller difference for treadmill, walking speed is reduced both on treadmill (.13 m s−1) and on overground (.17 m s−1) in PD. The self-select walking speed, stride length, cadence, double support, swing time and sagittal hip angle were altered in people with PD compared with healthy control. The precise determination of these modifications will be beneficial in determining which intervention elements are most critical in bringing about positive, clinically meaningful changes in individuals with PD (PROSPERO protocol CRD42018113042).
format	article
author	Ana Paula Janner Zanardi Edson Soares da Silva Rochelle Rocha Costa Elren Passos-Monteiro Ivan Oliveira dos Santos Luiz Fernando Martins Kruel Leonardo Alexandre Peyré-Tartaruga
author_facet	Ana Paula Janner Zanardi Edson Soares da Silva Rochelle Rocha Costa Elren Passos-Monteiro Ivan Oliveira dos Santos Luiz Fernando Martins Kruel Leonardo Alexandre Peyré-Tartaruga
author_sort	Ana Paula Janner Zanardi
title	Gait parameters of Parkinson’s disease compared with healthy controls: a systematic review and meta-analysis
title_short	Gait parameters of Parkinson’s disease compared with healthy controls: a systematic review and meta-analysis
title_full	Gait parameters of Parkinson’s disease compared with healthy controls: a systematic review and meta-analysis
title_fullStr	Gait parameters of Parkinson’s disease compared with healthy controls: a systematic review and meta-analysis
title_full_unstemmed	Gait parameters of Parkinson’s disease compared with healthy controls: a systematic review and meta-analysis
title_sort	gait parameters of parkinson’s disease compared with healthy controls: a systematic review and meta-analysis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/35bdfea70a65447e8db69f135a18fa76
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Gait parameters of Parkinson’s disease compared with healthy controls: a systematic review and meta-analysis

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