Functional anterior pituitary generated in self-organizing culture of human embryonic stem cells

Functional anterior pituitary generated in self-organizing culture of human embryonic stem cells

It is difficult to generate functional human anterior pituitary tissues in vitro. Here, Ozone et al. generate human anterior pituitary from embryonic stem cells by recapitulating in vivodevelopment, and demonstrate this tissue secretes hormones and rescues hypopituitarism when grafted into mice.

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Autores principales: Chikafumi Ozone, Hidetaka Suga, Mototsugu Eiraku, Taisuke Kadoshima, Shigenobu Yonemura, Nozomu Takata, Yutaka Oiso, Takashi Tsuji, Yoshiki Sasai
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Q
Acceso en línea:https://doaj.org/article/35be4cc4f7da4d0f83b9432016c75e6d
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spelling oai:doaj.org-article:35be4cc4f7da4d0f83b9432016c75e6d2021-12-02T14:38:34ZFunctional anterior pituitary generated in self-organizing culture of human embryonic stem cells10.1038/ncomms103512041-1723https://doaj.org/article/35be4cc4f7da4d0f83b9432016c75e6d2016-01-01T00:00:00Zhttps://doi.org/10.1038/ncomms10351https://doaj.org/toc/2041-1723It is difficult to generate functional human anterior pituitary tissues in vitro. Here, Ozone et al. generate human anterior pituitary from embryonic stem cells by recapitulating in vivodevelopment, and demonstrate this tissue secretes hormones and rescues hypopituitarism when grafted into mice.Chikafumi OzoneHidetaka SugaMototsugu EirakuTaisuke KadoshimaShigenobu YonemuraNozomu TakataYutaka OisoTakashi TsujiYoshiki SasaiNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Chikafumi Ozone
Hidetaka Suga
Mototsugu Eiraku
Taisuke Kadoshima
Shigenobu Yonemura
Nozomu Takata
Yutaka Oiso
Takashi Tsuji
Yoshiki Sasai
Functional anterior pituitary generated in self-organizing culture of human embryonic stem cells
description It is difficult to generate functional human anterior pituitary tissues in vitro. Here, Ozone et al. generate human anterior pituitary from embryonic stem cells by recapitulating in vivodevelopment, and demonstrate this tissue secretes hormones and rescues hypopituitarism when grafted into mice.
format article
author Chikafumi Ozone
Hidetaka Suga
Mototsugu Eiraku
Taisuke Kadoshima
Shigenobu Yonemura
Nozomu Takata
Yutaka Oiso
Takashi Tsuji
Yoshiki Sasai
author_facet Chikafumi Ozone
Hidetaka Suga
Mototsugu Eiraku
Taisuke Kadoshima
Shigenobu Yonemura
Nozomu Takata
Yutaka Oiso
Takashi Tsuji
Yoshiki Sasai
author_sort Chikafumi Ozone
title Functional anterior pituitary generated in self-organizing culture of human embryonic stem cells
title_short Functional anterior pituitary generated in self-organizing culture of human embryonic stem cells
title_full Functional anterior pituitary generated in self-organizing culture of human embryonic stem cells
title_fullStr Functional anterior pituitary generated in self-organizing culture of human embryonic stem cells
title_full_unstemmed Functional anterior pituitary generated in self-organizing culture of human embryonic stem cells
title_sort functional anterior pituitary generated in self-organizing culture of human embryonic stem cells
publisher Nature Portfolio
publishDate 2016
url https://doaj.org/article/35be4cc4f7da4d0f83b9432016c75e6d
work_keys_str_mv AT chikafumiozone functionalanteriorpituitarygeneratedinselforganizingcultureofhumanembryonicstemcells
AT hidetakasuga functionalanteriorpituitarygeneratedinselforganizingcultureofhumanembryonicstemcells
AT mototsugueiraku functionalanteriorpituitarygeneratedinselforganizingcultureofhumanembryonicstemcells
AT taisukekadoshima functionalanteriorpituitarygeneratedinselforganizingcultureofhumanembryonicstemcells
AT shigenobuyonemura functionalanteriorpituitarygeneratedinselforganizingcultureofhumanembryonicstemcells
AT nozomutakata functionalanteriorpituitarygeneratedinselforganizingcultureofhumanembryonicstemcells
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AT takashitsuji functionalanteriorpituitarygeneratedinselforganizingcultureofhumanembryonicstemcells
AT yoshikisasai functionalanteriorpituitarygeneratedinselforganizingcultureofhumanembryonicstemcells
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