Akt1 and dCIZ1 promote cell survival from apoptotic caspase activation during regeneration and oncogenic overgrowth

Although executioner caspase activation is considered terminal, some cells are capable of survival, suggesting additional regulation. Here, the authors show that cells in the Drosophila wing imaginal disc survive caspase activation via Akt1 and dCIZ1 and actively participate in tissue regeneration.

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Autores principales:	Gongping Sun, Xun Austin Ding, Yewubdar Argaw, Xiaoran Guo, Denise J. Montell
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/35c7dc6f1366445ca04e1cfcab4637c7
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id	oai:doaj.org-article:35c7dc6f1366445ca04e1cfcab4637c7
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spelling	oai:doaj.org-article:35c7dc6f1366445ca04e1cfcab4637c72021-12-02T14:41:24ZAkt1 and dCIZ1 promote cell survival from apoptotic caspase activation during regeneration and oncogenic overgrowth10.1038/s41467-020-19068-22041-1723https://doaj.org/article/35c7dc6f1366445ca04e1cfcab4637c72020-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19068-2https://doaj.org/toc/2041-1723Although executioner caspase activation is considered terminal, some cells are capable of survival, suggesting additional regulation. Here, the authors show that cells in the Drosophila wing imaginal disc survive caspase activation via Akt1 and dCIZ1 and actively participate in tissue regeneration.Gongping SunXun Austin DingYewubdar ArgawXiaoran GuoDenise J. MontellNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Gongping Sun Xun Austin Ding Yewubdar Argaw Xiaoran Guo Denise J. Montell Akt1 and dCIZ1 promote cell survival from apoptotic caspase activation during regeneration and oncogenic overgrowth
description	Although executioner caspase activation is considered terminal, some cells are capable of survival, suggesting additional regulation. Here, the authors show that cells in the Drosophila wing imaginal disc survive caspase activation via Akt1 and dCIZ1 and actively participate in tissue regeneration.
format	article
author	Gongping Sun Xun Austin Ding Yewubdar Argaw Xiaoran Guo Denise J. Montell
author_facet	Gongping Sun Xun Austin Ding Yewubdar Argaw Xiaoran Guo Denise J. Montell
author_sort	Gongping Sun
title	Akt1 and dCIZ1 promote cell survival from apoptotic caspase activation during regeneration and oncogenic overgrowth
title_short	Akt1 and dCIZ1 promote cell survival from apoptotic caspase activation during regeneration and oncogenic overgrowth
title_full	Akt1 and dCIZ1 promote cell survival from apoptotic caspase activation during regeneration and oncogenic overgrowth
title_fullStr	Akt1 and dCIZ1 promote cell survival from apoptotic caspase activation during regeneration and oncogenic overgrowth
title_full_unstemmed	Akt1 and dCIZ1 promote cell survival from apoptotic caspase activation during regeneration and oncogenic overgrowth
title_sort	akt1 and dciz1 promote cell survival from apoptotic caspase activation during regeneration and oncogenic overgrowth
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/35c7dc6f1366445ca04e1cfcab4637c7
work_keys_str_mv	AT gongpingsun akt1anddciz1promotecellsurvivalfromapoptoticcaspaseactivationduringregenerationandoncogenicovergrowth AT xunaustinding akt1anddciz1promotecellsurvivalfromapoptoticcaspaseactivationduringregenerationandoncogenicovergrowth AT yewubdarargaw akt1anddciz1promotecellsurvivalfromapoptoticcaspaseactivationduringregenerationandoncogenicovergrowth AT xiaoranguo akt1anddciz1promotecellsurvivalfromapoptoticcaspaseactivationduringregenerationandoncogenicovergrowth AT denisejmontell akt1anddciz1promotecellsurvivalfromapoptoticcaspaseactivationduringregenerationandoncogenicovergrowth
_version_	1718389862134972416

Akt1 and dCIZ1 promote cell survival from apoptotic caspase activation during regeneration and oncogenic overgrowth

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