MiREDiBase, a manually curated database of validated and putative editing events in microRNAs

Abstract MicroRNAs (miRNAs) are regulatory small non-coding RNAs that function as translational repressors. MiRNAs are involved in most cellular processes, and their expression and function are presided by several factors. Amongst, miRNA editing is an epitranscriptional modification that alters the...

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Autores principales:	Gioacchino P. Marceca, Rosario Distefano, Luisa Tomasello, Alessandro Lagana, Francesco Russo, Federica Calore, Giulia Romano, Marina Bagnoli, Pierluigi Gasparini, Alfredo Ferro, Mario Acunzo, Qin Ma, Carlo M. Croce, Giovanni Nigita
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/35c91d7ed5b145ce98b819e875e1d78d
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spelling	oai:doaj.org-article:35c91d7ed5b145ce98b819e875e1d78d2021-12-02T14:53:43ZMiREDiBase, a manually curated database of validated and putative editing events in microRNAs10.1038/s41597-021-00979-82052-4463https://doaj.org/article/35c91d7ed5b145ce98b819e875e1d78d2021-08-01T00:00:00Zhttps://doi.org/10.1038/s41597-021-00979-8https://doaj.org/toc/2052-4463Abstract MicroRNAs (miRNAs) are regulatory small non-coding RNAs that function as translational repressors. MiRNAs are involved in most cellular processes, and their expression and function are presided by several factors. Amongst, miRNA editing is an epitranscriptional modification that alters the original nucleotide sequence of selected miRNAs, possibly influencing their biogenesis and target-binding ability. A-to-I and C-to-U RNA editing are recognized as the canonical types, with the A-to-I type being the predominant one. Albeit some bioinformatics resources have been implemented to collect RNA editing data, it still lacks a comprehensive resource explicitly dedicated to miRNA editing. Here, we present MiREDiBase, a manually curated catalog of editing events in miRNAs. The current version includes 3,059 unique validated and putative editing sites from 626 pre-miRNAs in humans and three primates. Editing events in mature human miRNAs are supplied with miRNA-target predictions and enrichment analysis, while minimum free energy structures are inferred for edited pre-miRNAs. MiREDiBase represents a valuable tool for cell biology and biomedical research and will be continuously updated and expanded at https://ncrnaome.osumc.edu/miredibase .Gioacchino P. MarcecaRosario DistefanoLuisa TomaselloAlessandro LaganaFrancesco RussoFederica CaloreGiulia RomanoMarina BagnoliPierluigi GaspariniAlfredo FerroMario AcunzoQin MaCarlo M. CroceGiovanni NigitaNature PortfolioarticleScienceQENScientific Data, Vol 8, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Gioacchino P. Marceca Rosario Distefano Luisa Tomasello Alessandro Lagana Francesco Russo Federica Calore Giulia Romano Marina Bagnoli Pierluigi Gasparini Alfredo Ferro Mario Acunzo Qin Ma Carlo M. Croce Giovanni Nigita MiREDiBase, a manually curated database of validated and putative editing events in microRNAs
description	Abstract MicroRNAs (miRNAs) are regulatory small non-coding RNAs that function as translational repressors. MiRNAs are involved in most cellular processes, and their expression and function are presided by several factors. Amongst, miRNA editing is an epitranscriptional modification that alters the original nucleotide sequence of selected miRNAs, possibly influencing their biogenesis and target-binding ability. A-to-I and C-to-U RNA editing are recognized as the canonical types, with the A-to-I type being the predominant one. Albeit some bioinformatics resources have been implemented to collect RNA editing data, it still lacks a comprehensive resource explicitly dedicated to miRNA editing. Here, we present MiREDiBase, a manually curated catalog of editing events in miRNAs. The current version includes 3,059 unique validated and putative editing sites from 626 pre-miRNAs in humans and three primates. Editing events in mature human miRNAs are supplied with miRNA-target predictions and enrichment analysis, while minimum free energy structures are inferred for edited pre-miRNAs. MiREDiBase represents a valuable tool for cell biology and biomedical research and will be continuously updated and expanded at https://ncrnaome.osumc.edu/miredibase .
format	article
author	Gioacchino P. Marceca Rosario Distefano Luisa Tomasello Alessandro Lagana Francesco Russo Federica Calore Giulia Romano Marina Bagnoli Pierluigi Gasparini Alfredo Ferro Mario Acunzo Qin Ma Carlo M. Croce Giovanni Nigita
author_facet	Gioacchino P. Marceca Rosario Distefano Luisa Tomasello Alessandro Lagana Francesco Russo Federica Calore Giulia Romano Marina Bagnoli Pierluigi Gasparini Alfredo Ferro Mario Acunzo Qin Ma Carlo M. Croce Giovanni Nigita
author_sort	Gioacchino P. Marceca
title	MiREDiBase, a manually curated database of validated and putative editing events in microRNAs
title_short	MiREDiBase, a manually curated database of validated and putative editing events in microRNAs
title_full	MiREDiBase, a manually curated database of validated and putative editing events in microRNAs
title_fullStr	MiREDiBase, a manually curated database of validated and putative editing events in microRNAs
title_full_unstemmed	MiREDiBase, a manually curated database of validated and putative editing events in microRNAs
title_sort	miredibase, a manually curated database of validated and putative editing events in micrornas
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/35c91d7ed5b145ce98b819e875e1d78d
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MiREDiBase, a manually curated database of validated and putative editing events in microRNAs

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