Prediction of minimal hepatic encephalopathy by using an radiomics nomogram in chronic hepatic schistosomiasis patients.

<h4>Objective</h4>To construct an MR-radiomics nomogram to predict minimal hepatic encephalopathy (MHE) in patients with chronic hepatic schistosomiasis (CHS).<h4>Methods</h4>From July 2017 to July 2020, 236 CHS patients with non-HE (n = 140) and MHE (n = 96) were retrospecti...

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Autores principales:	Ying Li, Shuai Ju, Xin Li, Yan Li Zhou, Jin Wei Qiang
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270
Acceso en línea:	https://doaj.org/article/35cbfd0f1ee944c9870889ef62978932
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spelling	oai:doaj.org-article:35cbfd0f1ee944c9870889ef629789322021-12-02T20:23:25ZPrediction of minimal hepatic encephalopathy by using an radiomics nomogram in chronic hepatic schistosomiasis patients.1935-27271935-273510.1371/journal.pntd.0009834https://doaj.org/article/35cbfd0f1ee944c9870889ef629789322021-10-01T00:00:00Zhttps://doi.org/10.1371/journal.pntd.0009834https://doaj.org/toc/1935-2727https://doaj.org/toc/1935-2735<h4>Objective</h4>To construct an MR-radiomics nomogram to predict minimal hepatic encephalopathy (MHE) in patients with chronic hepatic schistosomiasis (CHS).<h4>Methods</h4>From July 2017 to July 2020, 236 CHS patients with non-HE (n = 140) and MHE (n = 96) were retrospective collected and randomly divided into training group and testing group. Radiomics features were extracted from substantia nigra-striatum system of a brain diffusion weighted images (DWI) and combined with clinical predictors to build a radiomics nomogram for predicting MHE in CHS patients. The ROC curve was used to evaluate the predicting performance in training group and testing group. The clinical decisive curve (CDC) was used to assess the clinical net benefit of using radiomics nomogram in predicting MHE.<h4>Results</h4>Low seralbumin (P < 0.05), low platelet count (P < 0.05) and high plasma ammonia (P < 0.05) was the significant clinical predictors for MHE in CHS patients. The AUC, specificity and sensitivity of the radiomics nomogram were 0.89, 0.90 and 0.86 in the training group, and were 0.83, 0.85 and 0.75 in the training group. The CDC analysis showed clinical net benefits for the radiomics nomogram in predicting MHE.<h4>Conclusions</h4>The radiomics nomogram combining DWI radiomics features and clinical predictors could be useful tool to predict MHE in CHS patients.Ying LiShuai JuXin LiYan Li ZhouJin Wei QiangPublic Library of Science (PLoS)articleArctic medicine. Tropical medicineRC955-962Public aspects of medicineRA1-1270ENPLoS Neglected Tropical Diseases, Vol 15, Iss 10, p e0009834 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270
spellingShingle	Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Ying Li Shuai Ju Xin Li Yan Li Zhou Jin Wei Qiang Prediction of minimal hepatic encephalopathy by using an radiomics nomogram in chronic hepatic schistosomiasis patients.
description	<h4>Objective</h4>To construct an MR-radiomics nomogram to predict minimal hepatic encephalopathy (MHE) in patients with chronic hepatic schistosomiasis (CHS).<h4>Methods</h4>From July 2017 to July 2020, 236 CHS patients with non-HE (n = 140) and MHE (n = 96) were retrospective collected and randomly divided into training group and testing group. Radiomics features were extracted from substantia nigra-striatum system of a brain diffusion weighted images (DWI) and combined with clinical predictors to build a radiomics nomogram for predicting MHE in CHS patients. The ROC curve was used to evaluate the predicting performance in training group and testing group. The clinical decisive curve (CDC) was used to assess the clinical net benefit of using radiomics nomogram in predicting MHE.<h4>Results</h4>Low seralbumin (P < 0.05), low platelet count (P < 0.05) and high plasma ammonia (P < 0.05) was the significant clinical predictors for MHE in CHS patients. The AUC, specificity and sensitivity of the radiomics nomogram were 0.89, 0.90 and 0.86 in the training group, and were 0.83, 0.85 and 0.75 in the training group. The CDC analysis showed clinical net benefits for the radiomics nomogram in predicting MHE.<h4>Conclusions</h4>The radiomics nomogram combining DWI radiomics features and clinical predictors could be useful tool to predict MHE in CHS patients.
format	article
author	Ying Li Shuai Ju Xin Li Yan Li Zhou Jin Wei Qiang
author_facet	Ying Li Shuai Ju Xin Li Yan Li Zhou Jin Wei Qiang
author_sort	Ying Li
title	Prediction of minimal hepatic encephalopathy by using an radiomics nomogram in chronic hepatic schistosomiasis patients.
title_short	Prediction of minimal hepatic encephalopathy by using an radiomics nomogram in chronic hepatic schistosomiasis patients.
title_full	Prediction of minimal hepatic encephalopathy by using an radiomics nomogram in chronic hepatic schistosomiasis patients.
title_fullStr	Prediction of minimal hepatic encephalopathy by using an radiomics nomogram in chronic hepatic schistosomiasis patients.
title_full_unstemmed	Prediction of minimal hepatic encephalopathy by using an radiomics nomogram in chronic hepatic schistosomiasis patients.
title_sort	prediction of minimal hepatic encephalopathy by using an radiomics nomogram in chronic hepatic schistosomiasis patients.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/35cbfd0f1ee944c9870889ef62978932
work_keys_str_mv	AT yingli predictionofminimalhepaticencephalopathybyusinganradiomicsnomograminchronichepaticschistosomiasispatients AT shuaiju predictionofminimalhepaticencephalopathybyusinganradiomicsnomograminchronichepaticschistosomiasispatients AT xinli predictionofminimalhepaticencephalopathybyusinganradiomicsnomograminchronichepaticschistosomiasispatients AT yanlizhou predictionofminimalhepaticencephalopathybyusinganradiomicsnomograminchronichepaticschistosomiasispatients AT jinweiqiang predictionofminimalhepaticencephalopathybyusinganradiomicsnomograminchronichepaticschistosomiasispatients
_version_	1718374099732922368

Prediction of minimal hepatic encephalopathy by using an radiomics nomogram in chronic hepatic schistosomiasis patients.

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