The role of TAp63γ and P53 point mutations in regulating DNA repair, mutational susceptibility and invasion of bladder cancer cells
It has long been recognized that non-muscle-invasive bladder cancer (NMIBC) has a low propensity (20%) of becoming muscle-invasive (MIBC), and that MIBC carry many more p53 point mutations (p53m) than NMIBC (50% vs 10%). MIBC also has a higher mutation burden than NMIBC. These results suggest that D...
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Main Authors: | Hsiang-Tsui Wang, Hyun-Wook Lee, Mao-wen Weng, Yan Liu, William C Huang, Herbert Lepor, Xue-Ru Wu, Moon-shong Tang |
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Format: | article |
Language: | EN |
Published: |
eLife Sciences Publications Ltd
2021
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Online Access: | https://doaj.org/article/35cdeaf8520d46078b684f45c7b6c5d6 |
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