The role of TAp63γ and P53 point mutations in regulating DNA repair, mutational susceptibility and invasion of bladder cancer cells

It has long been recognized that non-muscle-invasive bladder cancer (NMIBC) has a low propensity (20%) of becoming muscle-invasive (MIBC), and that MIBC carry many more p53 point mutations (p53m) than NMIBC (50% vs 10%). MIBC also has a higher mutation burden than NMIBC. These results suggest that D...

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Bibliographic Details
Main Authors: Hsiang-Tsui Wang, Hyun-Wook Lee, Mao-wen Weng, Yan Liu, William C Huang, Herbert Lepor, Xue-Ru Wu, Moon-shong Tang
Format: article
Language:EN
Published: eLife Sciences Publications Ltd 2021
Subjects:
R
Q
Online Access:https://doaj.org/article/35cdeaf8520d46078b684f45c7b6c5d6
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