Structure and dynamics of the active Gs-coupled human secretin receptor

The class B secretin GPCR (SecR) has broad physiological effects, with target potential for treatment of metabolic and cardiovascular disease. Here, authors present a cryo-EM structure and biochemical studies of secretin binding to the SecR:Gs complex which show that interactions between peptide and...

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Main Authors:	Maoqing Dong, Giuseppe Deganutti, Sarah J. Piper, Yi-Lynn Liang, Maryam Khoshouei, Matthew J. Belousoff, Kaleeckal G. Harikumar, Christopher A. Reynolds, Alisa Glukhova, Sebastian G. B. Furness, Arthur Christopoulos, Radostin Danev, Denise Wootten, Patrick M. Sexton, Laurence J. Miller
Format:	article
Language:	EN
Published:	Nature Portfolio 2020
Subjects:	Science Q
Online Access:	https://doaj.org/article/35d3a9f45d2f49f5b92ff1e2f30c175a
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spelling	oai:doaj.org-article:35d3a9f45d2f49f5b92ff1e2f30c175a2021-12-02T16:46:37ZStructure and dynamics of the active Gs-coupled human secretin receptor10.1038/s41467-020-17791-42041-1723https://doaj.org/article/35d3a9f45d2f49f5b92ff1e2f30c175a2020-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17791-4https://doaj.org/toc/2041-1723The class B secretin GPCR (SecR) has broad physiological effects, with target potential for treatment of metabolic and cardiovascular disease. Here, authors present a cryo-EM structure and biochemical studies of secretin binding to the SecR:Gs complex which show that interactions between peptide and receptor were dynamic.Maoqing DongGiuseppe DeganuttiSarah J. PiperYi-Lynn LiangMaryam KhoshoueiMatthew J. BelousoffKaleeckal G. HarikumarChristopher A. ReynoldsAlisa GlukhovaSebastian G. B. FurnessArthur ChristopoulosRadostin DanevDenise WoottenPatrick M. SextonLaurence J. MillerNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Maoqing Dong Giuseppe Deganutti Sarah J. Piper Yi-Lynn Liang Maryam Khoshouei Matthew J. Belousoff Kaleeckal G. Harikumar Christopher A. Reynolds Alisa Glukhova Sebastian G. B. Furness Arthur Christopoulos Radostin Danev Denise Wootten Patrick M. Sexton Laurence J. Miller Structure and dynamics of the active Gs-coupled human secretin receptor
description	The class B secretin GPCR (SecR) has broad physiological effects, with target potential for treatment of metabolic and cardiovascular disease. Here, authors present a cryo-EM structure and biochemical studies of secretin binding to the SecR:Gs complex which show that interactions between peptide and receptor were dynamic.
format	article
author	Maoqing Dong Giuseppe Deganutti Sarah J. Piper Yi-Lynn Liang Maryam Khoshouei Matthew J. Belousoff Kaleeckal G. Harikumar Christopher A. Reynolds Alisa Glukhova Sebastian G. B. Furness Arthur Christopoulos Radostin Danev Denise Wootten Patrick M. Sexton Laurence J. Miller
author_facet	Maoqing Dong Giuseppe Deganutti Sarah J. Piper Yi-Lynn Liang Maryam Khoshouei Matthew J. Belousoff Kaleeckal G. Harikumar Christopher A. Reynolds Alisa Glukhova Sebastian G. B. Furness Arthur Christopoulos Radostin Danev Denise Wootten Patrick M. Sexton Laurence J. Miller
author_sort	Maoqing Dong
title	Structure and dynamics of the active Gs-coupled human secretin receptor
title_short	Structure and dynamics of the active Gs-coupled human secretin receptor
title_full	Structure and dynamics of the active Gs-coupled human secretin receptor
title_fullStr	Structure and dynamics of the active Gs-coupled human secretin receptor
title_full_unstemmed	Structure and dynamics of the active Gs-coupled human secretin receptor
title_sort	structure and dynamics of the active gs-coupled human secretin receptor
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/35d3a9f45d2f49f5b92ff1e2f30c175a
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Structure and dynamics of the active Gs-coupled human secretin receptor

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