Microbiota instruct IL-17A-producing innate lymphoid cells to promote skin inflammation in cutaneous leishmaniasis.

Innate lymphoid cells (ILCs) comprise a heterogeneous population of immune cells that maintain barrier function and can initiate a protective or pathological immune response upon infection. Here we show the involvement of IL-17A-producing ILCs in microbiota-driven immunopathology in cutaneous leishm...

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Autores principales:	Tej Pratap Singh, Augusto M Carvalho, Laís Amorim Sacramento, Elizabeth A Grice, Phillip Scott
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/35d3daa506f84e8fa394d8b3e93e6253
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spelling	oai:doaj.org-article:35d3daa506f84e8fa394d8b3e93e62532021-12-02T19:59:58ZMicrobiota instruct IL-17A-producing innate lymphoid cells to promote skin inflammation in cutaneous leishmaniasis.1553-73661553-737410.1371/journal.ppat.1009693https://doaj.org/article/35d3daa506f84e8fa394d8b3e93e62532021-10-01T00:00:00Zhttps://doi.org/10.1371/journal.ppat.1009693https://doaj.org/toc/1553-7366https://doaj.org/toc/1553-7374Innate lymphoid cells (ILCs) comprise a heterogeneous population of immune cells that maintain barrier function and can initiate a protective or pathological immune response upon infection. Here we show the involvement of IL-17A-producing ILCs in microbiota-driven immunopathology in cutaneous leishmaniasis. IL-17A-producing ILCs were RORγt+ and were enriched in Leishmania major infected skin, and topical colonization with Staphylococcus epidermidis before L. major infection exacerbated the skin inflammatory responses and IL-17A-producing RORγt+ ILC accumulation without impacting type 1 immune responses. IL-17A responses in ILCs were directed by Batf3 dependent CD103+ dendritic cells and IL-23. Moreover, experiments using Rag1-/- mice established that IL-17A+ ILCs were sufficient in driving the inflammatory responses as depletion of ILCs or neutralization of IL-17A diminished the microbiota mediated immunopathology. Taken together, this study indicates that the skin microbiota promotes RORγt+ IL-17A-producing ILCs, which augment the skin inflammation in cutaneous leishmaniasis.Tej Pratap SinghAugusto M CarvalhoLaís Amorim SacramentoElizabeth A GricePhillip ScottPublic Library of Science (PLoS)articleImmunologic diseases. AllergyRC581-607Biology (General)QH301-705.5ENPLoS Pathogens, Vol 17, Iss 10, p e1009693 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5
spellingShingle	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5 Tej Pratap Singh Augusto M Carvalho Laís Amorim Sacramento Elizabeth A Grice Phillip Scott Microbiota instruct IL-17A-producing innate lymphoid cells to promote skin inflammation in cutaneous leishmaniasis.
description	Innate lymphoid cells (ILCs) comprise a heterogeneous population of immune cells that maintain barrier function and can initiate a protective or pathological immune response upon infection. Here we show the involvement of IL-17A-producing ILCs in microbiota-driven immunopathology in cutaneous leishmaniasis. IL-17A-producing ILCs were RORγt+ and were enriched in Leishmania major infected skin, and topical colonization with Staphylococcus epidermidis before L. major infection exacerbated the skin inflammatory responses and IL-17A-producing RORγt+ ILC accumulation without impacting type 1 immune responses. IL-17A responses in ILCs were directed by Batf3 dependent CD103+ dendritic cells and IL-23. Moreover, experiments using Rag1-/- mice established that IL-17A+ ILCs were sufficient in driving the inflammatory responses as depletion of ILCs or neutralization of IL-17A diminished the microbiota mediated immunopathology. Taken together, this study indicates that the skin microbiota promotes RORγt+ IL-17A-producing ILCs, which augment the skin inflammation in cutaneous leishmaniasis.
format	article
author	Tej Pratap Singh Augusto M Carvalho Laís Amorim Sacramento Elizabeth A Grice Phillip Scott
author_facet	Tej Pratap Singh Augusto M Carvalho Laís Amorim Sacramento Elizabeth A Grice Phillip Scott
author_sort	Tej Pratap Singh
title	Microbiota instruct IL-17A-producing innate lymphoid cells to promote skin inflammation in cutaneous leishmaniasis.
title_short	Microbiota instruct IL-17A-producing innate lymphoid cells to promote skin inflammation in cutaneous leishmaniasis.
title_full	Microbiota instruct IL-17A-producing innate lymphoid cells to promote skin inflammation in cutaneous leishmaniasis.
title_fullStr	Microbiota instruct IL-17A-producing innate lymphoid cells to promote skin inflammation in cutaneous leishmaniasis.
title_full_unstemmed	Microbiota instruct IL-17A-producing innate lymphoid cells to promote skin inflammation in cutaneous leishmaniasis.
title_sort	microbiota instruct il-17a-producing innate lymphoid cells to promote skin inflammation in cutaneous leishmaniasis.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/35d3daa506f84e8fa394d8b3e93e6253
work_keys_str_mv	AT tejpratapsingh microbiotainstructil17aproducinginnatelymphoidcellstopromoteskininflammationincutaneousleishmaniasis AT augustomcarvalho microbiotainstructil17aproducinginnatelymphoidcellstopromoteskininflammationincutaneousleishmaniasis AT laisamorimsacramento microbiotainstructil17aproducinginnatelymphoidcellstopromoteskininflammationincutaneousleishmaniasis AT elizabethagrice microbiotainstructil17aproducinginnatelymphoidcellstopromoteskininflammationincutaneousleishmaniasis AT phillipscott microbiotainstructil17aproducinginnatelymphoidcellstopromoteskininflammationincutaneousleishmaniasis
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Microbiota instruct IL-17A-producing innate lymphoid cells to promote skin inflammation in cutaneous leishmaniasis.

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