Structures of tweety homolog proteins TTYH2 and TTYH3 reveal a Ca2+-dependent switch from intra- to intermembrane dimerization

Tweety Homologs (TTYHs) are highly conserved membrane proteins, whose functions remain poorly understood. Here, the authors present the cryo-EM structures of murine TTYH2 and TTYH3 that form cis-dimers in the presence of Ca2+, whereas in the absence of Ca2+ TTYH2 adopts monomeric and trans-dimeric s...

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Autores principales:	Baobin Li, Christopher M. Hoel, Stephen G. Brohawn
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/35d41ab2716c4fb08b443aa80b6bed5c
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spelling	oai:doaj.org-article:35d41ab2716c4fb08b443aa80b6bed5c2021-11-28T12:35:55ZStructures of tweety homolog proteins TTYH2 and TTYH3 reveal a Ca2+-dependent switch from intra- to intermembrane dimerization10.1038/s41467-021-27283-82041-1723https://doaj.org/article/35d41ab2716c4fb08b443aa80b6bed5c2021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-27283-8https://doaj.org/toc/2041-1723Tweety Homologs (TTYHs) are highly conserved membrane proteins, whose functions remain poorly understood. Here, the authors present the cryo-EM structures of murine TTYH2 and TTYH3 that form cis-dimers in the presence of Ca2+, whereas in the absence of Ca2+ TTYH2 adopts monomeric and trans-dimeric structures. The presented structures lack ion conducting pathways, which is consistent with results from electrophysiology measurements.Baobin LiChristopher M. HoelStephen G. BrohawnNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Baobin Li Christopher M. Hoel Stephen G. Brohawn Structures of tweety homolog proteins TTYH2 and TTYH3 reveal a Ca2+-dependent switch from intra- to intermembrane dimerization
description	Tweety Homologs (TTYHs) are highly conserved membrane proteins, whose functions remain poorly understood. Here, the authors present the cryo-EM structures of murine TTYH2 and TTYH3 that form cis-dimers in the presence of Ca2+, whereas in the absence of Ca2+ TTYH2 adopts monomeric and trans-dimeric structures. The presented structures lack ion conducting pathways, which is consistent with results from electrophysiology measurements.
format	article
author	Baobin Li Christopher M. Hoel Stephen G. Brohawn
author_facet	Baobin Li Christopher M. Hoel Stephen G. Brohawn
author_sort	Baobin Li
title	Structures of tweety homolog proteins TTYH2 and TTYH3 reveal a Ca2+-dependent switch from intra- to intermembrane dimerization
title_short	Structures of tweety homolog proteins TTYH2 and TTYH3 reveal a Ca2+-dependent switch from intra- to intermembrane dimerization
title_full	Structures of tweety homolog proteins TTYH2 and TTYH3 reveal a Ca2+-dependent switch from intra- to intermembrane dimerization
title_fullStr	Structures of tweety homolog proteins TTYH2 and TTYH3 reveal a Ca2+-dependent switch from intra- to intermembrane dimerization
title_full_unstemmed	Structures of tweety homolog proteins TTYH2 and TTYH3 reveal a Ca2+-dependent switch from intra- to intermembrane dimerization
title_sort	structures of tweety homolog proteins ttyh2 and ttyh3 reveal a ca2+-dependent switch from intra- to intermembrane dimerization
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/35d41ab2716c4fb08b443aa80b6bed5c
work_keys_str_mv	AT baobinli structuresoftweetyhomologproteinsttyh2andttyh3revealaca2dependentswitchfromintratointermembranedimerization AT christophermhoel structuresoftweetyhomologproteinsttyh2andttyh3revealaca2dependentswitchfromintratointermembranedimerization AT stephengbrohawn structuresoftweetyhomologproteinsttyh2andttyh3revealaca2dependentswitchfromintratointermembranedimerization
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Structures of tweety homolog proteins TTYH2 and TTYH3 reveal a Ca2+-dependent switch from intra- to intermembrane dimerization

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