The genetic architecture of DNA replication timing in human pluripotent stem cells

The genetic basis of how cells replicate their DNA is not well understood. Here, the authors identify >1000 genetic elements that control human replication and reveal a complex epigenetic system that regulates replication origin activities.

Guardado en:

Detalles Bibliográficos
Autores principales:	Qiliang Ding, Matthew M. Edwards, Ning Wang, Xiang Zhu, Alexa N. Bracci, Michelle L. Hulke, Ya Hu, Yao Tong, Joyce Hsiao, Christine J. Charvet, Sulagna Ghosh, Robert E. Handsaker, Kevin Eggan, Florian T. Merkle, Jeannine Gerhardt, Dieter Egli, Andrew G. Clark, Amnon Koren
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/35d8b329749043bfb83a3cd38e9be893
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:35d8b329749043bfb83a3cd38e9be893
record_format	dspace
spelling	oai:doaj.org-article:35d8b329749043bfb83a3cd38e9be8932021-11-21T12:33:59ZThe genetic architecture of DNA replication timing in human pluripotent stem cells10.1038/s41467-021-27115-92041-1723https://doaj.org/article/35d8b329749043bfb83a3cd38e9be8932021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-27115-9https://doaj.org/toc/2041-1723The genetic basis of how cells replicate their DNA is not well understood. Here, the authors identify >1000 genetic elements that control human replication and reveal a complex epigenetic system that regulates replication origin activities.Qiliang DingMatthew M. EdwardsNing WangXiang ZhuAlexa N. BracciMichelle L. HulkeYa HuYao TongJoyce HsiaoChristine J. CharvetSulagna GhoshRobert E. HandsakerKevin EgganFlorian T. MerkleJeannine GerhardtDieter EgliAndrew G. ClarkAmnon KorenNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Qiliang Ding Matthew M. Edwards Ning Wang Xiang Zhu Alexa N. Bracci Michelle L. Hulke Ya Hu Yao Tong Joyce Hsiao Christine J. Charvet Sulagna Ghosh Robert E. Handsaker Kevin Eggan Florian T. Merkle Jeannine Gerhardt Dieter Egli Andrew G. Clark Amnon Koren The genetic architecture of DNA replication timing in human pluripotent stem cells
description	The genetic basis of how cells replicate their DNA is not well understood. Here, the authors identify >1000 genetic elements that control human replication and reveal a complex epigenetic system that regulates replication origin activities.
format	article
author	Qiliang Ding Matthew M. Edwards Ning Wang Xiang Zhu Alexa N. Bracci Michelle L. Hulke Ya Hu Yao Tong Joyce Hsiao Christine J. Charvet Sulagna Ghosh Robert E. Handsaker Kevin Eggan Florian T. Merkle Jeannine Gerhardt Dieter Egli Andrew G. Clark Amnon Koren
author_facet	Qiliang Ding Matthew M. Edwards Ning Wang Xiang Zhu Alexa N. Bracci Michelle L. Hulke Ya Hu Yao Tong Joyce Hsiao Christine J. Charvet Sulagna Ghosh Robert E. Handsaker Kevin Eggan Florian T. Merkle Jeannine Gerhardt Dieter Egli Andrew G. Clark Amnon Koren
author_sort	Qiliang Ding
title	The genetic architecture of DNA replication timing in human pluripotent stem cells
title_short	The genetic architecture of DNA replication timing in human pluripotent stem cells
title_full	The genetic architecture of DNA replication timing in human pluripotent stem cells
title_fullStr	The genetic architecture of DNA replication timing in human pluripotent stem cells
title_full_unstemmed	The genetic architecture of DNA replication timing in human pluripotent stem cells
title_sort	genetic architecture of dna replication timing in human pluripotent stem cells
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/35d8b329749043bfb83a3cd38e9be893
work_keys_str_mv	AT qiliangding thegeneticarchitectureofdnareplicationtiminginhumanpluripotentstemcells AT matthewmedwards thegeneticarchitectureofdnareplicationtiminginhumanpluripotentstemcells AT ningwang thegeneticarchitectureofdnareplicationtiminginhumanpluripotentstemcells AT xiangzhu thegeneticarchitectureofdnareplicationtiminginhumanpluripotentstemcells AT alexanbracci thegeneticarchitectureofdnareplicationtiminginhumanpluripotentstemcells AT michellelhulke thegeneticarchitectureofdnareplicationtiminginhumanpluripotentstemcells AT yahu thegeneticarchitectureofdnareplicationtiminginhumanpluripotentstemcells AT yaotong thegeneticarchitectureofdnareplicationtiminginhumanpluripotentstemcells AT joycehsiao thegeneticarchitectureofdnareplicationtiminginhumanpluripotentstemcells AT christinejcharvet thegeneticarchitectureofdnareplicationtiminginhumanpluripotentstemcells AT sulagnaghosh thegeneticarchitectureofdnareplicationtiminginhumanpluripotentstemcells AT robertehandsaker thegeneticarchitectureofdnareplicationtiminginhumanpluripotentstemcells AT kevineggan thegeneticarchitectureofdnareplicationtiminginhumanpluripotentstemcells AT floriantmerkle thegeneticarchitectureofdnareplicationtiminginhumanpluripotentstemcells AT jeanninegerhardt thegeneticarchitectureofdnareplicationtiminginhumanpluripotentstemcells AT dieteregli thegeneticarchitectureofdnareplicationtiminginhumanpluripotentstemcells AT andrewgclark thegeneticarchitectureofdnareplicationtiminginhumanpluripotentstemcells AT amnonkoren thegeneticarchitectureofdnareplicationtiminginhumanpluripotentstemcells AT qiliangding geneticarchitectureofdnareplicationtiminginhumanpluripotentstemcells AT matthewmedwards geneticarchitectureofdnareplicationtiminginhumanpluripotentstemcells AT ningwang geneticarchitectureofdnareplicationtiminginhumanpluripotentstemcells AT xiangzhu geneticarchitectureofdnareplicationtiminginhumanpluripotentstemcells AT alexanbracci geneticarchitectureofdnareplicationtiminginhumanpluripotentstemcells AT michellelhulke geneticarchitectureofdnareplicationtiminginhumanpluripotentstemcells AT yahu geneticarchitectureofdnareplicationtiminginhumanpluripotentstemcells AT yaotong geneticarchitectureofdnareplicationtiminginhumanpluripotentstemcells AT joycehsiao geneticarchitectureofdnareplicationtiminginhumanpluripotentstemcells AT christinejcharvet geneticarchitectureofdnareplicationtiminginhumanpluripotentstemcells AT sulagnaghosh geneticarchitectureofdnareplicationtiminginhumanpluripotentstemcells AT robertehandsaker geneticarchitectureofdnareplicationtiminginhumanpluripotentstemcells AT kevineggan geneticarchitectureofdnareplicationtiminginhumanpluripotentstemcells AT floriantmerkle geneticarchitectureofdnareplicationtiminginhumanpluripotentstemcells AT jeanninegerhardt geneticarchitectureofdnareplicationtiminginhumanpluripotentstemcells AT dieteregli geneticarchitectureofdnareplicationtiminginhumanpluripotentstemcells AT andrewgclark geneticarchitectureofdnareplicationtiminginhumanpluripotentstemcells AT amnonkoren geneticarchitectureofdnareplicationtiminginhumanpluripotentstemcells
_version_	1718418935365238784

The genetic architecture of DNA replication timing in human pluripotent stem cells

Ejemplares similares