The genetic architecture of DNA replication timing in human pluripotent stem cells

The genetic architecture of DNA replication timing in human pluripotent stem cells

The genetic basis of how cells replicate their DNA is not well understood. Here, the authors identify >1000 genetic elements that control human replication and reveal a complex epigenetic system that regulates replication origin activities.

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Bibliographic Details
Main Authors: Qiliang Ding, Matthew M. Edwards, Ning Wang, Xiang Zhu, Alexa N. Bracci, Michelle L. Hulke, Ya Hu, Yao Tong, Joyce Hsiao, Christine J. Charvet, Sulagna Ghosh, Robert E. Handsaker, Kevin Eggan, Florian T. Merkle, Jeannine Gerhardt, Dieter Egli, Andrew G. Clark, Amnon Koren
Format: article
Language:EN
Published: Nature Portfolio 2021
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Science
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Online Access:https://doaj.org/article/35d8b329749043bfb83a3cd38e9be893
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https://doaj.org/article/35d8b329749043bfb83a3cd38e9be893

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