Styrene maleic acid-encapsulated paclitaxel micelles: antitumor activity and toxicity studies following oral administration in a murine orthotopic colon cancer model

Neha N Parayath,1 Hayley Nehoff,1 Samuel E Norton,2 Andrew J Highton,2 Sebastien Taurin,1,3 Roslyn A Kemp,2 Khaled Greish1,4 1Department of Pharmacology and Toxicology, 2Department of Microbiology and Immunology, University of Otago, Dunedin, New Zealand; 3Department of Obstetrics and Gynecology, U...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Parayath NN, Nehoff H, Norton SE, Highton AJ, Taurin S, Kemp RA, Greish K
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	Styrene maleic acid paclitaxel oral delivery colon cancer anticancer nanomedicine CT-26 enhanced permeability and retention effect (EPR). Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/35ded1d9a73f4908b5df23c64a2e70d5
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:35ded1d9a73f4908b5df23c64a2e70d5
record_format	dspace
spelling	oai:doaj.org-article:35ded1d9a73f4908b5df23c64a2e70d52021-12-02T01:50:21ZStyrene maleic acid-encapsulated paclitaxel micelles: antitumor activity and toxicity studies following oral administration in a murine orthotopic colon cancer model1178-2013https://doaj.org/article/35ded1d9a73f4908b5df23c64a2e70d52016-08-01T00:00:00Zhttps://www.dovepress.com/styrene-maleic-acid-encapsulated-paclitaxel-micelles-antitumor-activit-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Neha N Parayath,1 Hayley Nehoff,1 Samuel E Norton,2 Andrew J Highton,2 Sebastien Taurin,1,3 Roslyn A Kemp,2 Khaled Greish1,4 1Department of Pharmacology and Toxicology, 2Department of Microbiology and Immunology, University of Otago, Dunedin, New Zealand; 3Department of Obstetrics and Gynecology, University of Utah, Salt Lake City, UT, USA; 4Princess Al-Jawhara Centre for Molecular Medicine, Arabian Gulf University, Manama, Kingdom of Bahrain Abstract: Oral administration of paclitaxel (PTX), a broad spectrum anticancer agent, is challenged by its low uptake due to its poor bioavailability, efflux through P-glycoprotein, and gastrointestinal toxicity. We synthesized PTX nanomicelles using poly(styrene-co-maleic acid) (SMA). Oral administration of SMA-PTX micelles doubled the maximum tolerated dose (60 mg/kg vs 30 mg/kg) compared to the commercially available PTX formulation (PTX [Ebewe]). In a murine orthotopic colon cancer model, oral administration of SMA-PTX micelles at doses 30 mg/kg and 60 mg/kg reduced tumor weight by 54% and 69%, respectively, as compared to the control group, while no significant reduction in tumor weight was observed with 30 mg/kg of PTX (Ebewe). In addition, toxicity of PTX was largely reduced by its encapsulation into SMA. Furthermore, examination of the tumors demonstrated a decrease in the number of blood vessels. Thus, oral delivery of SMA-PTX micelles may provide a safe and effective strategy for the treatment of colon cancer. Keywords: oral delivery, anticancer nanomedicine, CT-26, enhanced permeability and retention (EPR) effect, HUVEC, antiangiogenicParayath NNNehoff HNorton SEHighton AJTaurin SKemp RAGreish KDove Medical PressarticleStyrene maleic acidpaclitaxeloral deliverycolon canceranticancer nanomedicineCT-26enhanced permeability and retention effect (EPR).Medicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 11, Pp 3979-3991 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Styrene maleic acid paclitaxel oral delivery colon cancer anticancer nanomedicine CT-26 enhanced permeability and retention effect (EPR). Medicine (General) R5-920
spellingShingle	Styrene maleic acid paclitaxel oral delivery colon cancer anticancer nanomedicine CT-26 enhanced permeability and retention effect (EPR). Medicine (General) R5-920 Parayath NN Nehoff H Norton SE Highton AJ Taurin S Kemp RA Greish K Styrene maleic acid-encapsulated paclitaxel micelles: antitumor activity and toxicity studies following oral administration in a murine orthotopic colon cancer model
description	Neha N Parayath,1 Hayley Nehoff,1 Samuel E Norton,2 Andrew J Highton,2 Sebastien Taurin,1,3 Roslyn A Kemp,2 Khaled Greish1,4 1Department of Pharmacology and Toxicology, 2Department of Microbiology and Immunology, University of Otago, Dunedin, New Zealand; 3Department of Obstetrics and Gynecology, University of Utah, Salt Lake City, UT, USA; 4Princess Al-Jawhara Centre for Molecular Medicine, Arabian Gulf University, Manama, Kingdom of Bahrain Abstract: Oral administration of paclitaxel (PTX), a broad spectrum anticancer agent, is challenged by its low uptake due to its poor bioavailability, efflux through P-glycoprotein, and gastrointestinal toxicity. We synthesized PTX nanomicelles using poly(styrene-co-maleic acid) (SMA). Oral administration of SMA-PTX micelles doubled the maximum tolerated dose (60 mg/kg vs 30 mg/kg) compared to the commercially available PTX formulation (PTX [Ebewe]). In a murine orthotopic colon cancer model, oral administration of SMA-PTX micelles at doses 30 mg/kg and 60 mg/kg reduced tumor weight by 54% and 69%, respectively, as compared to the control group, while no significant reduction in tumor weight was observed with 30 mg/kg of PTX (Ebewe). In addition, toxicity of PTX was largely reduced by its encapsulation into SMA. Furthermore, examination of the tumors demonstrated a decrease in the number of blood vessels. Thus, oral delivery of SMA-PTX micelles may provide a safe and effective strategy for the treatment of colon cancer. Keywords: oral delivery, anticancer nanomedicine, CT-26, enhanced permeability and retention (EPR) effect, HUVEC, antiangiogenic
format	article
author	Parayath NN Nehoff H Norton SE Highton AJ Taurin S Kemp RA Greish K
author_facet	Parayath NN Nehoff H Norton SE Highton AJ Taurin S Kemp RA Greish K
author_sort	Parayath NN
title	Styrene maleic acid-encapsulated paclitaxel micelles: antitumor activity and toxicity studies following oral administration in a murine orthotopic colon cancer model
title_short	Styrene maleic acid-encapsulated paclitaxel micelles: antitumor activity and toxicity studies following oral administration in a murine orthotopic colon cancer model
title_full	Styrene maleic acid-encapsulated paclitaxel micelles: antitumor activity and toxicity studies following oral administration in a murine orthotopic colon cancer model
title_fullStr	Styrene maleic acid-encapsulated paclitaxel micelles: antitumor activity and toxicity studies following oral administration in a murine orthotopic colon cancer model
title_full_unstemmed	Styrene maleic acid-encapsulated paclitaxel micelles: antitumor activity and toxicity studies following oral administration in a murine orthotopic colon cancer model
title_sort	styrene maleic acid-encapsulated paclitaxel micelles: antitumor activity and toxicity studies following oral administration in a murine orthotopic colon cancer model
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/35ded1d9a73f4908b5df23c64a2e70d5
work_keys_str_mv	AT parayathnn styrenemaleicacidencapsulatedpaclitaxelmicellesantitumoractivityandtoxicitystudiesfollowingoraladministrationinamurineorthotopiccoloncancermodel AT nehoffh styrenemaleicacidencapsulatedpaclitaxelmicellesantitumoractivityandtoxicitystudiesfollowingoraladministrationinamurineorthotopiccoloncancermodel AT nortonse styrenemaleicacidencapsulatedpaclitaxelmicellesantitumoractivityandtoxicitystudiesfollowingoraladministrationinamurineorthotopiccoloncancermodel AT hightonaj styrenemaleicacidencapsulatedpaclitaxelmicellesantitumoractivityandtoxicitystudiesfollowingoraladministrationinamurineorthotopiccoloncancermodel AT taurins styrenemaleicacidencapsulatedpaclitaxelmicellesantitumoractivityandtoxicitystudiesfollowingoraladministrationinamurineorthotopiccoloncancermodel AT kempra styrenemaleicacidencapsulatedpaclitaxelmicellesantitumoractivityandtoxicitystudiesfollowingoraladministrationinamurineorthotopiccoloncancermodel AT greishk styrenemaleicacidencapsulatedpaclitaxelmicellesantitumoractivityandtoxicitystudiesfollowingoraladministrationinamurineorthotopiccoloncancermodel
_version_	1718402828427329536

Styrene maleic acid-encapsulated paclitaxel micelles: antitumor activity and toxicity studies following oral administration in a murine orthotopic colon cancer model

Ejemplares similares