Novel clones of Streptococcus pneumoniae causing invasive disease in Malaysia.

Although Streptococcus pneumoniae is a leading cause of childhood disease in South East Asia, little has previously been reported regarding the epidemiology of invasive pneumococcal disease in Malaysia and very few studies have explored pneumococcal epidemiology using multilocus sequence typing (MLS...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Johanna M Jefferies, Mohd Yasim Mohd Yusof, Shamala Devi Sekaran, Stuart C Clarke
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/35e05d486b994f288d1506462d23c5b4
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:35e05d486b994f288d1506462d23c5b4
record_format	dspace
spelling	oai:doaj.org-article:35e05d486b994f288d1506462d23c5b42021-11-18T08:15:13ZNovel clones of Streptococcus pneumoniae causing invasive disease in Malaysia.1932-620310.1371/journal.pone.0097912https://doaj.org/article/35e05d486b994f288d1506462d23c5b42014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24941079/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Although Streptococcus pneumoniae is a leading cause of childhood disease in South East Asia, little has previously been reported regarding the epidemiology of invasive pneumococcal disease in Malaysia and very few studies have explored pneumococcal epidemiology using multilocus sequence typing (MLST). Here we describe serotype, multilocus sequence type (ST), and penicillin susceptibility of thirty pneumococcal invasive disease isolates received by the University of Malaya Medical Centre between February 2000 and January 2007 and relate this to the serotypes included in current pneumococcal conjugate vaccines. A high level of diversity was observed; fourteen serotypes and 26 sequence types (ST), (11 of which were not previously described) were detected from 30 isolates. Penicillin non-susceptible pneumococci accounted for 33% of isolates. The extent of molecular heterogeneity within carried and disease-causing Malaysian pneumococci remains unknown. Larger surveillance and epidemiological studies are now required in this region to provide robust evidence on which to base future vaccine policy.Johanna M JefferiesMohd Yasim Mohd YusofShamala Devi SekaranStuart C ClarkePublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 6, p e97912 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Johanna M Jefferies Mohd Yasim Mohd Yusof Shamala Devi Sekaran Stuart C Clarke Novel clones of Streptococcus pneumoniae causing invasive disease in Malaysia.
description	Although Streptococcus pneumoniae is a leading cause of childhood disease in South East Asia, little has previously been reported regarding the epidemiology of invasive pneumococcal disease in Malaysia and very few studies have explored pneumococcal epidemiology using multilocus sequence typing (MLST). Here we describe serotype, multilocus sequence type (ST), and penicillin susceptibility of thirty pneumococcal invasive disease isolates received by the University of Malaya Medical Centre between February 2000 and January 2007 and relate this to the serotypes included in current pneumococcal conjugate vaccines. A high level of diversity was observed; fourteen serotypes and 26 sequence types (ST), (11 of which were not previously described) were detected from 30 isolates. Penicillin non-susceptible pneumococci accounted for 33% of isolates. The extent of molecular heterogeneity within carried and disease-causing Malaysian pneumococci remains unknown. Larger surveillance and epidemiological studies are now required in this region to provide robust evidence on which to base future vaccine policy.
format	article
author	Johanna M Jefferies Mohd Yasim Mohd Yusof Shamala Devi Sekaran Stuart C Clarke
author_facet	Johanna M Jefferies Mohd Yasim Mohd Yusof Shamala Devi Sekaran Stuart C Clarke
author_sort	Johanna M Jefferies
title	Novel clones of Streptococcus pneumoniae causing invasive disease in Malaysia.
title_short	Novel clones of Streptococcus pneumoniae causing invasive disease in Malaysia.
title_full	Novel clones of Streptococcus pneumoniae causing invasive disease in Malaysia.
title_fullStr	Novel clones of Streptococcus pneumoniae causing invasive disease in Malaysia.
title_full_unstemmed	Novel clones of Streptococcus pneumoniae causing invasive disease in Malaysia.
title_sort	novel clones of streptococcus pneumoniae causing invasive disease in malaysia.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/35e05d486b994f288d1506462d23c5b4
work_keys_str_mv	AT johannamjefferies novelclonesofstreptococcuspneumoniaecausinginvasivediseaseinmalaysia AT mohdyasimmohdyusof novelclonesofstreptococcuspneumoniaecausinginvasivediseaseinmalaysia AT shamaladevisekaran novelclonesofstreptococcuspneumoniaecausinginvasivediseaseinmalaysia AT stuartcclarke novelclonesofstreptococcuspneumoniaecausinginvasivediseaseinmalaysia
_version_	1718421976628854784

Novel clones of Streptococcus pneumoniae causing invasive disease in Malaysia.

Ejemplares similares