Activators of alpha synuclein expression identified by reporter cell line-based high throughput drug screen

Activators of alpha synuclein expression identified by reporter cell line-based high throughput drug screen

Abstract Multiplications, mutations and dysregulation of the alpha synuclein gene (SNCA) are associated with the demise of dopaminergic neurons and are considered to play important roles in the pathogenesis of familial and sporadic forms of Parkinson’s disease. Regulation of SNCA expression might th...

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Autores principales: Fabian Stahl, Philip Denner, Dominik Piston, Bernd O. Evert, Laura de Boni, Ina Schmitt, Peter Breuer, Ullrich Wüllner
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
Medicine
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Science
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Acceso en línea:https://doaj.org/article/35e23d580f6a483d801a8bf67c002435
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