Role of Rho Guanine Nucleotide Exchange Factors in Non-Small Cell Lung Cancer

Conventionally, Rho guanine nucleotide exchange factors (GEFs) are known activators of Rho guanosine triphosphatases (GTPases) that promote tumorigenesis. However, the role of Rho GEFs in non-small cell lung cancer (NSCLC) remains largely unknown. Through the screening of 81 Rho GEFs for their expre...

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Autores principales:	Rui-Jie Zeng, Wei-Jie Xie, Chun-Wen Zheng, Wan-Xian Chen, Si-Meng Wang, Zheng Li, Chi-Bin Cheng, Hai-Ying Zou, Li-Yan Xu, En-Min Li
Formato:	article
Lenguaje:	EN
Publicado:	Taylor & Francis Group 2021
Materias:	rho gefs abr prex1 dock2 dock4 nsclc Biotechnology TP248.13-248.65
Acceso en línea:	https://doaj.org/article/35e8a165d4994866af3143e4c9754c06
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spelling	oai:doaj.org-article:35e8a165d4994866af3143e4c9754c062021-11-17T14:21:59ZRole of Rho Guanine Nucleotide Exchange Factors in Non-Small Cell Lung Cancer2165-59792165-598710.1080/21655979.2021.2006519https://doaj.org/article/35e8a165d4994866af3143e4c9754c062021-11-01T00:00:00Zhttp://dx.doi.org/10.1080/21655979.2021.2006519https://doaj.org/toc/2165-5979https://doaj.org/toc/2165-5987Conventionally, Rho guanine nucleotide exchange factors (GEFs) are known activators of Rho guanosine triphosphatases (GTPases) that promote tumorigenesis. However, the role of Rho GEFs in non-small cell lung cancer (NSCLC) remains largely unknown. Through the screening of 81 Rho GEFs for their expression profiles and correlations with survival, four of them were identified with strong significance for predicting the prognosis of NSCLC patients. The four Rho GEFs, namely ABR, PREX1, DOCK2 and DOCK4, were downregulated in NSCLC tissues compared to normal tissues. The downregulation of ABR, PREX1, DOCK2 and DOCK4, which can be attributed to promoter methylation, is correlated with poor prognosis. The underexpression of the four key Rho GEFs might be related to the upregulation of MYC signaling and DNA repair pathways, leading to carcinogenesis and poor prognosis. Moreover, overexpression of ABR was shown to have a tumor-suppressive effect in PC9 and H1703 cells. In conclusion, the data reveal the unprecedented role of ABR as tumor suppressor in NSCLC. The previously unnoticed functions of Rho GEFs in NSCLC will inspire researchers to investigate the distinct roles of Rho GEFs in cancers, in order to provide critical strategies in clinical practice.Rui-Jie ZengWei-Jie XieChun-Wen ZhengWan-Xian ChenSi-Meng WangZheng LiChi-Bin ChengHai-Ying ZouLi-Yan XuEn-Min LiTaylor & Francis Grouparticlerho gefsabrprex1dock2dock4nsclcBiotechnologyTP248.13-248.65ENBioengineered, Vol 0, Iss 0 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	rho gefs abr prex1 dock2 dock4 nsclc Biotechnology TP248.13-248.65
spellingShingle	rho gefs abr prex1 dock2 dock4 nsclc Biotechnology TP248.13-248.65 Rui-Jie Zeng Wei-Jie Xie Chun-Wen Zheng Wan-Xian Chen Si-Meng Wang Zheng Li Chi-Bin Cheng Hai-Ying Zou Li-Yan Xu En-Min Li Role of Rho Guanine Nucleotide Exchange Factors in Non-Small Cell Lung Cancer
description	Conventionally, Rho guanine nucleotide exchange factors (GEFs) are known activators of Rho guanosine triphosphatases (GTPases) that promote tumorigenesis. However, the role of Rho GEFs in non-small cell lung cancer (NSCLC) remains largely unknown. Through the screening of 81 Rho GEFs for their expression profiles and correlations with survival, four of them were identified with strong significance for predicting the prognosis of NSCLC patients. The four Rho GEFs, namely ABR, PREX1, DOCK2 and DOCK4, were downregulated in NSCLC tissues compared to normal tissues. The downregulation of ABR, PREX1, DOCK2 and DOCK4, which can be attributed to promoter methylation, is correlated with poor prognosis. The underexpression of the four key Rho GEFs might be related to the upregulation of MYC signaling and DNA repair pathways, leading to carcinogenesis and poor prognosis. Moreover, overexpression of ABR was shown to have a tumor-suppressive effect in PC9 and H1703 cells. In conclusion, the data reveal the unprecedented role of ABR as tumor suppressor in NSCLC. The previously unnoticed functions of Rho GEFs in NSCLC will inspire researchers to investigate the distinct roles of Rho GEFs in cancers, in order to provide critical strategies in clinical practice.
format	article
author	Rui-Jie Zeng Wei-Jie Xie Chun-Wen Zheng Wan-Xian Chen Si-Meng Wang Zheng Li Chi-Bin Cheng Hai-Ying Zou Li-Yan Xu En-Min Li
author_facet	Rui-Jie Zeng Wei-Jie Xie Chun-Wen Zheng Wan-Xian Chen Si-Meng Wang Zheng Li Chi-Bin Cheng Hai-Ying Zou Li-Yan Xu En-Min Li
author_sort	Rui-Jie Zeng
title	Role of Rho Guanine Nucleotide Exchange Factors in Non-Small Cell Lung Cancer
title_short	Role of Rho Guanine Nucleotide Exchange Factors in Non-Small Cell Lung Cancer
title_full	Role of Rho Guanine Nucleotide Exchange Factors in Non-Small Cell Lung Cancer
title_fullStr	Role of Rho Guanine Nucleotide Exchange Factors in Non-Small Cell Lung Cancer
title_full_unstemmed	Role of Rho Guanine Nucleotide Exchange Factors in Non-Small Cell Lung Cancer
title_sort	role of rho guanine nucleotide exchange factors in non-small cell lung cancer
publisher	Taylor & Francis Group
publishDate	2021
url	https://doaj.org/article/35e8a165d4994866af3143e4c9754c06
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Role of Rho Guanine Nucleotide Exchange Factors in Non-Small Cell Lung Cancer

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