THE BIOTIC FACTOR OF TREMATOD OPISTHORHIS FELINEUS INVASION INFLUENCE ON HOST IMMUNE STATUS AND SOMATIC CELLS PROLIFERATIVE ACTIVITY

The paper confirms long-time opisthorhis invasion role as a risk factor of host immune system reconstitution as well as an important factor in holangiocarcinomas development. It was shown that opisthorhosis invasion primal stage induce host immune system reconstitution. Host immune B-cells system is...

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Autor principal:	A. G. Rybka
Formato:	article
Lenguaje:	RU
Publicado:	Sankt-Peterburg : NIIÈM imeni Pastera 2016
Materias:	immune status immune response immunocompetent cells allergic reactions antigens antibodies immune complexes opisthorchiasis chronic/long opisthorchosis invasion proliferative activity carcinogenesis cholangiocarcinoma Infectious and parasitic diseases RC109-216
Acceso en línea:	https://doaj.org/article/35e8ddde66c74de18add1f2199adef64
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spelling	oai:doaj.org-article:35e8ddde66c74de18add1f2199adef642021-11-22T07:09:48ZTHE BIOTIC FACTOR OF TREMATOD OPISTHORHIS FELINEUS INVASION INFLUENCE ON HOST IMMUNE STATUS AND SOMATIC CELLS PROLIFERATIVE ACTIVITY2220-76192313-739810.15789/2220-7619-2016-3-232-236https://doaj.org/article/35e8ddde66c74de18add1f2199adef642016-09-01T00:00:00Zhttps://www.iimmun.ru/iimm/article/view/423https://doaj.org/toc/2220-7619https://doaj.org/toc/2313-7398The paper confirms long-time opisthorhis invasion role as a risk factor of host immune system reconstitution as well as an important factor in holangiocarcinomas development. It was shown that opisthorhosis invasion primal stage induce host immune system reconstitution. Host immune B-cells system is activated by metacercaria antigens, while the same antigens inhibits T-cells activity. Opisthorhis metabolites stimulate proliferative mithogen-induced T-cells acti vity. Chronic opisthorchis invasion leads to immune system disbalance. It means: decrease of specific and non-speci fic natural killers activity, number of high proliferative activity T-lymphocytes and the shift of regulatory T-cells subset to suppressors prevalence. At the same time specific as well as non-specific T-suppressors functional ability is very low. It was shown T-cells helper-amplifier activation. Despite of circulating B-cells decrease the antibody produced cells number is spleen increases significantly at the same time with circulating immune complexes accumulation. Even 3–6 month after dehelmintisation the immune system disbalance decreases but lefts. In addition, chronic opisthorhis invasion leads to the proliferative processes activation in ductal epithelium, liver, lymph nodes and in other organs which leads to cancer proliferation. According to the results obtained the opisthorhis infected patients needs to be immunocorrected before as well as after dehelmintisation for holangiocancerogenesis profylaxis.A. G. RybkaSankt-Peterburg : NIIÈM imeni Pasteraarticleimmune statusimmune responseimmunocompetent cellsallergic reactionsantigensantibodiesimmune complexesopisthorchiasischronic/long opisthorchosis invasionproliferative activitycarcinogenesischolangiocarcinomaInfectious and parasitic diseasesRC109-216RUInfekciâ i Immunitet, Vol 6, Iss 3, Pp 232-236 (2016)
institution	DOAJ
collection	DOAJ
language	RU
topic	immune status immune response immunocompetent cells allergic reactions antigens antibodies immune complexes opisthorchiasis chronic/long opisthorchosis invasion proliferative activity carcinogenesis cholangiocarcinoma Infectious and parasitic diseases RC109-216
spellingShingle	immune status immune response immunocompetent cells allergic reactions antigens antibodies immune complexes opisthorchiasis chronic/long opisthorchosis invasion proliferative activity carcinogenesis cholangiocarcinoma Infectious and parasitic diseases RC109-216 A. G. Rybka THE BIOTIC FACTOR OF TREMATOD OPISTHORHIS FELINEUS INVASION INFLUENCE ON HOST IMMUNE STATUS AND SOMATIC CELLS PROLIFERATIVE ACTIVITY
description	The paper confirms long-time opisthorhis invasion role as a risk factor of host immune system reconstitution as well as an important factor in holangiocarcinomas development. It was shown that opisthorhosis invasion primal stage induce host immune system reconstitution. Host immune B-cells system is activated by metacercaria antigens, while the same antigens inhibits T-cells activity. Opisthorhis metabolites stimulate proliferative mithogen-induced T-cells acti vity. Chronic opisthorchis invasion leads to immune system disbalance. It means: decrease of specific and non-speci fic natural killers activity, number of high proliferative activity T-lymphocytes and the shift of regulatory T-cells subset to suppressors prevalence. At the same time specific as well as non-specific T-suppressors functional ability is very low. It was shown T-cells helper-amplifier activation. Despite of circulating B-cells decrease the antibody produced cells number is spleen increases significantly at the same time with circulating immune complexes accumulation. Even 3–6 month after dehelmintisation the immune system disbalance decreases but lefts. In addition, chronic opisthorhis invasion leads to the proliferative processes activation in ductal epithelium, liver, lymph nodes and in other organs which leads to cancer proliferation. According to the results obtained the opisthorhis infected patients needs to be immunocorrected before as well as after dehelmintisation for holangiocancerogenesis profylaxis.
format	article
author	A. G. Rybka
author_facet	A. G. Rybka
author_sort	A. G. Rybka
title	THE BIOTIC FACTOR OF TREMATOD OPISTHORHIS FELINEUS INVASION INFLUENCE ON HOST IMMUNE STATUS AND SOMATIC CELLS PROLIFERATIVE ACTIVITY
title_short	THE BIOTIC FACTOR OF TREMATOD OPISTHORHIS FELINEUS INVASION INFLUENCE ON HOST IMMUNE STATUS AND SOMATIC CELLS PROLIFERATIVE ACTIVITY
title_full	THE BIOTIC FACTOR OF TREMATOD OPISTHORHIS FELINEUS INVASION INFLUENCE ON HOST IMMUNE STATUS AND SOMATIC CELLS PROLIFERATIVE ACTIVITY
title_fullStr	THE BIOTIC FACTOR OF TREMATOD OPISTHORHIS FELINEUS INVASION INFLUENCE ON HOST IMMUNE STATUS AND SOMATIC CELLS PROLIFERATIVE ACTIVITY
title_full_unstemmed	THE BIOTIC FACTOR OF TREMATOD OPISTHORHIS FELINEUS INVASION INFLUENCE ON HOST IMMUNE STATUS AND SOMATIC CELLS PROLIFERATIVE ACTIVITY
title_sort	biotic factor of trematod opisthorhis felineus invasion influence on host immune status and somatic cells proliferative activity
publisher	Sankt-Peterburg : NIIÈM imeni Pastera
publishDate	2016
url	https://doaj.org/article/35e8ddde66c74de18add1f2199adef64
work_keys_str_mv	AT agrybka thebioticfactoroftrematodopisthorhisfelineusinvasioninfluenceonhostimmunestatusandsomaticcellsproliferativeactivity AT agrybka bioticfactoroftrematodopisthorhisfelineusinvasioninfluenceonhostimmunestatusandsomaticcellsproliferativeactivity
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THE BIOTIC FACTOR OF TREMATOD OPISTHORHIS FELINEUS INVASION INFLUENCE ON HOST IMMUNE STATUS AND SOMATIC CELLS PROLIFERATIVE ACTIVITY

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