3D-Printed Replica and Porcine Explants for Pre-Clinical Optimization of Endoscopic Tumor Treatment by Magnetic Targeting

Background: Animal models have limitations in cancer research, especially regarding anatomy-specific questions. An example is the exact endoscopic placement of magnetic field traps for the targeting of therapeutic nanoparticles. Three-dimensional-printed human replicas may be used to overcome these...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Anjali A. Roeth, Ian Garretson, Maja Beltz, Till Herbold, Maximilian Schulze-Hagen, Sebastian Quaisser, Alex Georgens, Dirk Reith, Ioana Slabu, Christian D. Klink, Ulf P. Neumann, Barbara S. Linke
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	3D printing pancreatic cancer models replica magnetic nanoparticles magnetic hyperthermia Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/35ecd730019d400c91087a48433307f1
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:35ecd730019d400c91087a48433307f1
record_format	dspace
spelling	oai:doaj.org-article:35ecd730019d400c91087a48433307f12021-11-11T15:33:44Z3D-Printed Replica and Porcine Explants for Pre-Clinical Optimization of Endoscopic Tumor Treatment by Magnetic Targeting10.3390/cancers132154962072-6694https://doaj.org/article/35ecd730019d400c91087a48433307f12021-11-01T00:00:00Zhttps://www.mdpi.com/2072-6694/13/21/5496https://doaj.org/toc/2072-6694Background: Animal models have limitations in cancer research, especially regarding anatomy-specific questions. An example is the exact endoscopic placement of magnetic field traps for the targeting of therapeutic nanoparticles. Three-dimensional-printed human replicas may be used to overcome these pitfalls. Methods: We developed a transparent method to fabricate a patient-specific replica, allowing for a broad scope of application. As an example, we then additively manufactured the relevant organs of a patient with locally advanced pancreatic ductal adenocarcinoma. We performed experimental design investigations for a magnetic field trap and explored the best fixation methods on an explanted porcine stomach wall. Results: We describe in detail the eight-step development of a 3D replica from CT data. To guide further users in their decisions, a morphologic box was created. Endoscopies were performed on the replica and the resulting magnetic field was investigated. The best fixation method to hold the magnetic field traps stably in place was the fixation of loops at the stomach wall with endoscopic single-use clips. Conclusions: Using only open access software, the developed method may be used for a variety of cancer-related research questions. A detailed description of the workflow allows one to produce a 3D replica for research or training purposes at low costs.Anjali A. RoethIan GarretsonMaja BeltzTill HerboldMaximilian Schulze-HagenSebastian QuaisserAlex GeorgensDirk ReithIoana SlabuChristian D. KlinkUlf P. NeumannBarbara S. LinkeMDPI AGarticle3D printingpancreatic cancermodelsreplicamagnetic nanoparticlesmagnetic hyperthermiaNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENCancers, Vol 13, Iss 5496, p 5496 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	3D printing pancreatic cancer models replica magnetic nanoparticles magnetic hyperthermia Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	3D printing pancreatic cancer models replica magnetic nanoparticles magnetic hyperthermia Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Anjali A. Roeth Ian Garretson Maja Beltz Till Herbold Maximilian Schulze-Hagen Sebastian Quaisser Alex Georgens Dirk Reith Ioana Slabu Christian D. Klink Ulf P. Neumann Barbara S. Linke 3D-Printed Replica and Porcine Explants for Pre-Clinical Optimization of Endoscopic Tumor Treatment by Magnetic Targeting
description	Background: Animal models have limitations in cancer research, especially regarding anatomy-specific questions. An example is the exact endoscopic placement of magnetic field traps for the targeting of therapeutic nanoparticles. Three-dimensional-printed human replicas may be used to overcome these pitfalls. Methods: We developed a transparent method to fabricate a patient-specific replica, allowing for a broad scope of application. As an example, we then additively manufactured the relevant organs of a patient with locally advanced pancreatic ductal adenocarcinoma. We performed experimental design investigations for a magnetic field trap and explored the best fixation methods on an explanted porcine stomach wall. Results: We describe in detail the eight-step development of a 3D replica from CT data. To guide further users in their decisions, a morphologic box was created. Endoscopies were performed on the replica and the resulting magnetic field was investigated. The best fixation method to hold the magnetic field traps stably in place was the fixation of loops at the stomach wall with endoscopic single-use clips. Conclusions: Using only open access software, the developed method may be used for a variety of cancer-related research questions. A detailed description of the workflow allows one to produce a 3D replica for research or training purposes at low costs.
format	article
author	Anjali A. Roeth Ian Garretson Maja Beltz Till Herbold Maximilian Schulze-Hagen Sebastian Quaisser Alex Georgens Dirk Reith Ioana Slabu Christian D. Klink Ulf P. Neumann Barbara S. Linke
author_facet	Anjali A. Roeth Ian Garretson Maja Beltz Till Herbold Maximilian Schulze-Hagen Sebastian Quaisser Alex Georgens Dirk Reith Ioana Slabu Christian D. Klink Ulf P. Neumann Barbara S. Linke
author_sort	Anjali A. Roeth
title	3D-Printed Replica and Porcine Explants for Pre-Clinical Optimization of Endoscopic Tumor Treatment by Magnetic Targeting
title_short	3D-Printed Replica and Porcine Explants for Pre-Clinical Optimization of Endoscopic Tumor Treatment by Magnetic Targeting
title_full	3D-Printed Replica and Porcine Explants for Pre-Clinical Optimization of Endoscopic Tumor Treatment by Magnetic Targeting
title_fullStr	3D-Printed Replica and Porcine Explants for Pre-Clinical Optimization of Endoscopic Tumor Treatment by Magnetic Targeting
title_full_unstemmed	3D-Printed Replica and Porcine Explants for Pre-Clinical Optimization of Endoscopic Tumor Treatment by Magnetic Targeting
title_sort	3d-printed replica and porcine explants for pre-clinical optimization of endoscopic tumor treatment by magnetic targeting
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/35ecd730019d400c91087a48433307f1
work_keys_str_mv	AT anjaliaroeth 3dprintedreplicaandporcineexplantsforpreclinicaloptimizationofendoscopictumortreatmentbymagnetictargeting AT iangarretson 3dprintedreplicaandporcineexplantsforpreclinicaloptimizationofendoscopictumortreatmentbymagnetictargeting AT majabeltz 3dprintedreplicaandporcineexplantsforpreclinicaloptimizationofendoscopictumortreatmentbymagnetictargeting AT tillherbold 3dprintedreplicaandporcineexplantsforpreclinicaloptimizationofendoscopictumortreatmentbymagnetictargeting AT maximilianschulzehagen 3dprintedreplicaandporcineexplantsforpreclinicaloptimizationofendoscopictumortreatmentbymagnetictargeting AT sebastianquaisser 3dprintedreplicaandporcineexplantsforpreclinicaloptimizationofendoscopictumortreatmentbymagnetictargeting AT alexgeorgens 3dprintedreplicaandporcineexplantsforpreclinicaloptimizationofendoscopictumortreatmentbymagnetictargeting AT dirkreith 3dprintedreplicaandporcineexplantsforpreclinicaloptimizationofendoscopictumortreatmentbymagnetictargeting AT ioanaslabu 3dprintedreplicaandporcineexplantsforpreclinicaloptimizationofendoscopictumortreatmentbymagnetictargeting AT christiandklink 3dprintedreplicaandporcineexplantsforpreclinicaloptimizationofendoscopictumortreatmentbymagnetictargeting AT ulfpneumann 3dprintedreplicaandporcineexplantsforpreclinicaloptimizationofendoscopictumortreatmentbymagnetictargeting AT barbaraslinke 3dprintedreplicaandporcineexplantsforpreclinicaloptimizationofendoscopictumortreatmentbymagnetictargeting
_version_	1718435170612150272

3D-Printed Replica and Porcine Explants for Pre-Clinical Optimization of Endoscopic Tumor Treatment by Magnetic Targeting

Ejemplares similares