Reactogenicity to major tuberculosis antigens absent in BCG is linked to improved protection against Mycobacterium tuberculosis

MTBVAC, a live attenuatedMycobacterium tuberculosisvaccine under clinical evaluation, contains the major tuberculosis antigens ESAT6 and CFP10, which are absent from the current vaccine, BCG. Here, the authors show that these antigens contribute to enhanced vaccine efficacy in mouse models.

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Autores principales:	Nacho Aguilo, Jesus Gonzalo-Asensio, Samuel Alvarez-Arguedas, Dessislava Marinova, Ana Belen Gomez, Santiago Uranga, Ralf Spallek, Mahavir Singh, Regine Audran, François Spertini, Carlos Martin
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/35ef7cab9f89487f836fea009d468458
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spelling	oai:doaj.org-article:35ef7cab9f89487f836fea009d4684582021-12-02T17:06:24ZReactogenicity to major tuberculosis antigens absent in BCG is linked to improved protection against Mycobacterium tuberculosis10.1038/ncomms160852041-1723https://doaj.org/article/35ef7cab9f89487f836fea009d4684582017-07-01T00:00:00Zhttps://doi.org/10.1038/ncomms16085https://doaj.org/toc/2041-1723MTBVAC, a live attenuatedMycobacterium tuberculosisvaccine under clinical evaluation, contains the major tuberculosis antigens ESAT6 and CFP10, which are absent from the current vaccine, BCG. Here, the authors show that these antigens contribute to enhanced vaccine efficacy in mouse models.Nacho AguiloJesus Gonzalo-AsensioSamuel Alvarez-ArguedasDessislava MarinovaAna Belen GomezSantiago UrangaRalf SpallekMahavir SinghRegine AudranFrançois SpertiniCarlos MartinNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Nacho Aguilo Jesus Gonzalo-Asensio Samuel Alvarez-Arguedas Dessislava Marinova Ana Belen Gomez Santiago Uranga Ralf Spallek Mahavir Singh Regine Audran François Spertini Carlos Martin Reactogenicity to major tuberculosis antigens absent in BCG is linked to improved protection against Mycobacterium tuberculosis
description	MTBVAC, a live attenuatedMycobacterium tuberculosisvaccine under clinical evaluation, contains the major tuberculosis antigens ESAT6 and CFP10, which are absent from the current vaccine, BCG. Here, the authors show that these antigens contribute to enhanced vaccine efficacy in mouse models.
format	article
author	Nacho Aguilo Jesus Gonzalo-Asensio Samuel Alvarez-Arguedas Dessislava Marinova Ana Belen Gomez Santiago Uranga Ralf Spallek Mahavir Singh Regine Audran François Spertini Carlos Martin
author_facet	Nacho Aguilo Jesus Gonzalo-Asensio Samuel Alvarez-Arguedas Dessislava Marinova Ana Belen Gomez Santiago Uranga Ralf Spallek Mahavir Singh Regine Audran François Spertini Carlos Martin
author_sort	Nacho Aguilo
title	Reactogenicity to major tuberculosis antigens absent in BCG is linked to improved protection against Mycobacterium tuberculosis
title_short	Reactogenicity to major tuberculosis antigens absent in BCG is linked to improved protection against Mycobacterium tuberculosis
title_full	Reactogenicity to major tuberculosis antigens absent in BCG is linked to improved protection against Mycobacterium tuberculosis
title_fullStr	Reactogenicity to major tuberculosis antigens absent in BCG is linked to improved protection against Mycobacterium tuberculosis
title_full_unstemmed	Reactogenicity to major tuberculosis antigens absent in BCG is linked to improved protection against Mycobacterium tuberculosis
title_sort	reactogenicity to major tuberculosis antigens absent in bcg is linked to improved protection against mycobacterium tuberculosis
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/35ef7cab9f89487f836fea009d468458
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Reactogenicity to major tuberculosis antigens absent in BCG is linked to improved protection against Mycobacterium tuberculosis

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