Unraveling the genetic etiology of adult antisocial behavior: a genome-wide association study.

Crime poses a major burden for society. The heterogeneous nature of criminal behavior makes it difficult to unravel its causes. Relatively little research has been conducted on the genetic influences of criminal behavior. The few twin and adoption studies that have been undertaken suggest that about...

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Autores principales:	Jorim J Tielbeek, Sarah E Medland, Beben Benyamin, Enda M Byrne, Andrew C Heath, Pamela A F Madden, Nicholas G Martin, Naomi R Wray, Karin J H Verweij
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/35f1f12d420747e49363bdc27ffee990
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spelling	oai:doaj.org-article:35f1f12d420747e49363bdc27ffee9902021-11-18T08:12:08ZUnraveling the genetic etiology of adult antisocial behavior: a genome-wide association study.1932-620310.1371/journal.pone.0045086https://doaj.org/article/35f1f12d420747e49363bdc27ffee9902012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23077488/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Crime poses a major burden for society. The heterogeneous nature of criminal behavior makes it difficult to unravel its causes. Relatively little research has been conducted on the genetic influences of criminal behavior. The few twin and adoption studies that have been undertaken suggest that about half of the variance in antisocial behavior can be explained by genetic factors. In order to identify the specific common genetic variants underlying this behavior, we conduct the first genome-wide association study (GWAS) on adult antisocial behavior. Our sample comprised a community sample of 4816 individuals who had completed a self-report questionnaire. No genetic polymorphisms reached genome-wide significance for association with adult antisocial behavior. In addition, none of the traditional candidate genes can be confirmed in our study. While not genome-wide significant, the gene with the strongest association (p-value = 8.7×10(-5)) was DYRK1A, a gene previously related to abnormal brain development and mental retardation. Future studies should use larger, more homogeneous samples to disentangle the etiology of antisocial behavior. Biosocial criminological research allows a more empirically grounded understanding of criminal behavior, which could ultimately inform and improve current treatment strategies.Jorim J TielbeekSarah E MedlandBeben BenyaminEnda M ByrneAndrew C HeathPamela A F MaddenNicholas G MartinNaomi R WrayKarin J H VerweijPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 10, p e45086 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jorim J Tielbeek Sarah E Medland Beben Benyamin Enda M Byrne Andrew C Heath Pamela A F Madden Nicholas G Martin Naomi R Wray Karin J H Verweij Unraveling the genetic etiology of adult antisocial behavior: a genome-wide association study.
description	Crime poses a major burden for society. The heterogeneous nature of criminal behavior makes it difficult to unravel its causes. Relatively little research has been conducted on the genetic influences of criminal behavior. The few twin and adoption studies that have been undertaken suggest that about half of the variance in antisocial behavior can be explained by genetic factors. In order to identify the specific common genetic variants underlying this behavior, we conduct the first genome-wide association study (GWAS) on adult antisocial behavior. Our sample comprised a community sample of 4816 individuals who had completed a self-report questionnaire. No genetic polymorphisms reached genome-wide significance for association with adult antisocial behavior. In addition, none of the traditional candidate genes can be confirmed in our study. While not genome-wide significant, the gene with the strongest association (p-value = 8.7×10(-5)) was DYRK1A, a gene previously related to abnormal brain development and mental retardation. Future studies should use larger, more homogeneous samples to disentangle the etiology of antisocial behavior. Biosocial criminological research allows a more empirically grounded understanding of criminal behavior, which could ultimately inform and improve current treatment strategies.
format	article
author	Jorim J Tielbeek Sarah E Medland Beben Benyamin Enda M Byrne Andrew C Heath Pamela A F Madden Nicholas G Martin Naomi R Wray Karin J H Verweij
author_facet	Jorim J Tielbeek Sarah E Medland Beben Benyamin Enda M Byrne Andrew C Heath Pamela A F Madden Nicholas G Martin Naomi R Wray Karin J H Verweij
author_sort	Jorim J Tielbeek
title	Unraveling the genetic etiology of adult antisocial behavior: a genome-wide association study.
title_short	Unraveling the genetic etiology of adult antisocial behavior: a genome-wide association study.
title_full	Unraveling the genetic etiology of adult antisocial behavior: a genome-wide association study.
title_fullStr	Unraveling the genetic etiology of adult antisocial behavior: a genome-wide association study.
title_full_unstemmed	Unraveling the genetic etiology of adult antisocial behavior: a genome-wide association study.
title_sort	unraveling the genetic etiology of adult antisocial behavior: a genome-wide association study.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/35f1f12d420747e49363bdc27ffee990
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Unraveling the genetic etiology of adult antisocial behavior: a genome-wide association study.

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