Gestational age-specific sex difference in mortality and morbidities of preterm infants: A nationwide study

Abstract This study aims to determine whether male sex has adverse effect on mortality and morbidities in very low birth weight infants (VLBWI) <30 weeks of gestation and to ascertain this sex effect, stratified by gestational age, adjusting for perinatal risk factors. This is a population-based...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	So-Yeon Shim, Su Jin Cho, Kyoung Ae Kong, Eun Ae Park
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/35f387a94d704e3c90c3755a9808d794
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:35f387a94d704e3c90c3755a9808d794
record_format	dspace
spelling	oai:doaj.org-article:35f387a94d704e3c90c3755a9808d7942021-12-02T12:32:08ZGestational age-specific sex difference in mortality and morbidities of preterm infants: A nationwide study10.1038/s41598-017-06490-82045-2322https://doaj.org/article/35f387a94d704e3c90c3755a9808d7942017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-06490-8https://doaj.org/toc/2045-2322Abstract This study aims to determine whether male sex has adverse effect on mortality and morbidities in very low birth weight infants (VLBWI) <30 weeks of gestation and to ascertain this sex effect, stratified by gestational age, adjusting for perinatal risk factors. This is a population-based study from Korean Neonatal Network for VLBWI born at 23+0 and 29+6 weeks of gestation between January 2013 and December 2014. The primary outcome was gestation-specific sex difference in the occurrence of mortality, combined morbidities, and individual morbidity. A total of 2228 VLBWI were enrolled (males, 51.7%). Mortality was not different between sexes. The risk of bronchopulmonary dysplasia and combined morbidities was significantly higher in males ≤25 weeks of gestation (odds ratio [OR] 2.08, 95% confidence interval [CI] 1.35–3.20 and OR 2.00, CI 1.19–3.39, respectively). Males had a significantly higher incidence of periventricular leukomalacia at 23 and 29 weeks of gestation. The risk of severe retinopathy of prematurity was higher in females >25 weeks of gestation. Although both sexes have similar risk for mortality, male sex remains an independent risk for major morbidities, especially at ≤25 weeks of gestation. The risk of each outcome for males has a specific pattern with increasing gestational age.So-Yeon ShimSu Jin ChoKyoung Ae KongEun Ae ParkNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-8 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q So-Yeon Shim Su Jin Cho Kyoung Ae Kong Eun Ae Park Gestational age-specific sex difference in mortality and morbidities of preterm infants: A nationwide study
description	Abstract This study aims to determine whether male sex has adverse effect on mortality and morbidities in very low birth weight infants (VLBWI) <30 weeks of gestation and to ascertain this sex effect, stratified by gestational age, adjusting for perinatal risk factors. This is a population-based study from Korean Neonatal Network for VLBWI born at 23+0 and 29+6 weeks of gestation between January 2013 and December 2014. The primary outcome was gestation-specific sex difference in the occurrence of mortality, combined morbidities, and individual morbidity. A total of 2228 VLBWI were enrolled (males, 51.7%). Mortality was not different between sexes. The risk of bronchopulmonary dysplasia and combined morbidities was significantly higher in males ≤25 weeks of gestation (odds ratio [OR] 2.08, 95% confidence interval [CI] 1.35–3.20 and OR 2.00, CI 1.19–3.39, respectively). Males had a significantly higher incidence of periventricular leukomalacia at 23 and 29 weeks of gestation. The risk of severe retinopathy of prematurity was higher in females >25 weeks of gestation. Although both sexes have similar risk for mortality, male sex remains an independent risk for major morbidities, especially at ≤25 weeks of gestation. The risk of each outcome for males has a specific pattern with increasing gestational age.
format	article
author	So-Yeon Shim Su Jin Cho Kyoung Ae Kong Eun Ae Park
author_facet	So-Yeon Shim Su Jin Cho Kyoung Ae Kong Eun Ae Park
author_sort	So-Yeon Shim
title	Gestational age-specific sex difference in mortality and morbidities of preterm infants: A nationwide study
title_short	Gestational age-specific sex difference in mortality and morbidities of preterm infants: A nationwide study
title_full	Gestational age-specific sex difference in mortality and morbidities of preterm infants: A nationwide study
title_fullStr	Gestational age-specific sex difference in mortality and morbidities of preterm infants: A nationwide study
title_full_unstemmed	Gestational age-specific sex difference in mortality and morbidities of preterm infants: A nationwide study
title_sort	gestational age-specific sex difference in mortality and morbidities of preterm infants: a nationwide study
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/35f387a94d704e3c90c3755a9808d794
work_keys_str_mv	AT soyeonshim gestationalagespecificsexdifferenceinmortalityandmorbiditiesofpreterminfantsanationwidestudy AT sujincho gestationalagespecificsexdifferenceinmortalityandmorbiditiesofpreterminfantsanationwidestudy AT kyoungaekong gestationalagespecificsexdifferenceinmortalityandmorbiditiesofpreterminfantsanationwidestudy AT eunaepark gestationalagespecificsexdifferenceinmortalityandmorbiditiesofpreterminfantsanationwidestudy
_version_	1718394148272209920

Gestational age-specific sex difference in mortality and morbidities of preterm infants: A nationwide study

Ejemplares similares