Ibuprofen-loaded poly(lactic-co-glycolic acid) films for controlled drug release

Jianmei Pang1, Yuxia Luan1, Feifei Li1, Xiaoqing Cai1, Jimin Du2, Zhonghao Li31School of Pharmaceutical Science, Shandong University, Jinan, Shandong Province, PR China; 2School of Chemistry and Chemical Engineering, Anyang Normal University, Henan Province, PR China; 3School of Materials Science an...

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Autores principales:	Pang JM, Luan YX, Li FF, Cai XQ, Du&nbsp;JM,&nbsp;Li ZH
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2011
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/35fa4858db6c41feb4fcb04c7b38464f
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spelling	oai:doaj.org-article:35fa4858db6c41feb4fcb04c7b38464f2021-12-02T04:21:21ZIbuprofen-loaded poly(lactic-co-glycolic acid) films for controlled drug release1176-91141178-2013https://doaj.org/article/35fa4858db6c41feb4fcb04c7b38464f2011-04-01T00:00:00Zhttp://www.dovepress.com/ibuprofen-loaded-polylactic-co-glycolic-acid-films-for-controlled-drug-a6933https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Jianmei Pang1, Yuxia Luan1, Feifei Li1, Xiaoqing Cai1, Jimin Du2, Zhonghao Li31School of Pharmaceutical Science, Shandong University, Jinan, Shandong Province, PR China; 2School of Chemistry and Chemical Engineering, Anyang Normal University, Henan Province, PR China; 3School of Materials Science and Engineering, Shandong University, Jinan, Shandong Province, PR ChinaAbstract: Ibuprofen- (IBU) loaded biocompatible poly(lactic-co-glycolic acid) (PLGA) films were prepared by spreading polymer/ibuprofen solution on the nonsolvent surface. By controlling the weight ratio of drug and polymer, different drug loading polymer films can be obtained. The synthesized ibuprofen-loaded PLGA films were characterized with scanning electron microscopy, powder X-ray diffraction, and differential scanning calorimetry. The drug release behavior of the as-prepared IBU-loaded PLGA films was studied to reveal their potential application in drug delivery systems. The results show the feasibility of the as-obtained films for controlling drug release. Furthermore, the drug release rate of the film could be controlled by the drug loading content and the release medium. The development of a biodegradable ibuprofen system, based on films, should be of great interest in drug delivery systems.Keywords: ibuprofen, controlled release, poly(lactic-co-glycolic acid), films Pang JMLuan YXLi FFCai XQDu&nbsp;JM,&nbsp;Li ZHDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2011, Iss default, Pp 659-665 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Pang JM Luan YX Li FF Cai XQ Du&nbsp;JM,&nbsp;Li ZH Ibuprofen-loaded poly(lactic-co-glycolic acid) films for controlled drug release
description	Jianmei Pang1, Yuxia Luan1, Feifei Li1, Xiaoqing Cai1, Jimin Du2, Zhonghao Li31School of Pharmaceutical Science, Shandong University, Jinan, Shandong Province, PR China; 2School of Chemistry and Chemical Engineering, Anyang Normal University, Henan Province, PR China; 3School of Materials Science and Engineering, Shandong University, Jinan, Shandong Province, PR ChinaAbstract: Ibuprofen- (IBU) loaded biocompatible poly(lactic-co-glycolic acid) (PLGA) films were prepared by spreading polymer/ibuprofen solution on the nonsolvent surface. By controlling the weight ratio of drug and polymer, different drug loading polymer films can be obtained. The synthesized ibuprofen-loaded PLGA films were characterized with scanning electron microscopy, powder X-ray diffraction, and differential scanning calorimetry. The drug release behavior of the as-prepared IBU-loaded PLGA films was studied to reveal their potential application in drug delivery systems. The results show the feasibility of the as-obtained films for controlling drug release. Furthermore, the drug release rate of the film could be controlled by the drug loading content and the release medium. The development of a biodegradable ibuprofen system, based on films, should be of great interest in drug delivery systems.Keywords: ibuprofen, controlled release, poly(lactic-co-glycolic acid), films
format	article
author	Pang JM Luan YX Li FF Cai XQ Du&nbsp;JM,&nbsp;Li ZH
author_facet	Pang JM Luan YX Li FF Cai XQ Du&nbsp;JM,&nbsp;Li ZH
author_sort	Pang JM
title	Ibuprofen-loaded poly(lactic-co-glycolic acid) films for controlled drug release
title_short	Ibuprofen-loaded poly(lactic-co-glycolic acid) films for controlled drug release
title_full	Ibuprofen-loaded poly(lactic-co-glycolic acid) films for controlled drug release
title_fullStr	Ibuprofen-loaded poly(lactic-co-glycolic acid) films for controlled drug release
title_full_unstemmed	Ibuprofen-loaded poly(lactic-co-glycolic acid) films for controlled drug release
title_sort	ibuprofen-loaded poly(lactic-co-glycolic acid) films for controlled drug release
publisher	Dove Medical Press
publishDate	2011
url	https://doaj.org/article/35fa4858db6c41feb4fcb04c7b38464f
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Ibuprofen-loaded poly(lactic-co-glycolic acid) films for controlled drug release

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