Engineering protein assemblies with allosteric control via monomer fold-switching

The design of protein assemblies is a major thrust for biomolecular engineering and nanobiotechnology. Here the authors demonstrate a general mechanism for designing allosteric macromolecular assemblies and showcase a proof of concept for engineered allosteric protein assembly.

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Detalles Bibliográficos
Autores principales:	Luis A. Campos, Rajendra Sharma, Sara Alvira, Federico M. Ruiz, Beatriz Ibarra-Molero, Mourad Sadqi, Carlos Alfonso, Germán Rivas, Jose M. Sanchez-Ruiz, Antonio Romero Garrido, José M. Valpuesta, Victor Muñoz
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/35fa5f2626334f038b8530ed1e35e4fe
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spelling	oai:doaj.org-article:35fa5f2626334f038b8530ed1e35e4fe2021-12-02T17:02:02ZEngineering protein assemblies with allosteric control via monomer fold-switching10.1038/s41467-019-13686-12041-1723https://doaj.org/article/35fa5f2626334f038b8530ed1e35e4fe2019-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13686-1https://doaj.org/toc/2041-1723The design of protein assemblies is a major thrust for biomolecular engineering and nanobiotechnology. Here the authors demonstrate a general mechanism for designing allosteric macromolecular assemblies and showcase a proof of concept for engineered allosteric protein assembly.Luis A. CamposRajendra SharmaSara AlviraFederico M. RuizBeatriz Ibarra-MoleroMourad SadqiCarlos AlfonsoGermán RivasJose M. Sanchez-RuizAntonio Romero GarridoJosé M. ValpuestaVictor MuñozNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Luis A. Campos Rajendra Sharma Sara Alvira Federico M. Ruiz Beatriz Ibarra-Molero Mourad Sadqi Carlos Alfonso Germán Rivas Jose M. Sanchez-Ruiz Antonio Romero Garrido José M. Valpuesta Victor Muñoz Engineering protein assemblies with allosteric control via monomer fold-switching
description	The design of protein assemblies is a major thrust for biomolecular engineering and nanobiotechnology. Here the authors demonstrate a general mechanism for designing allosteric macromolecular assemblies and showcase a proof of concept for engineered allosteric protein assembly.
format	article
author	Luis A. Campos Rajendra Sharma Sara Alvira Federico M. Ruiz Beatriz Ibarra-Molero Mourad Sadqi Carlos Alfonso Germán Rivas Jose M. Sanchez-Ruiz Antonio Romero Garrido José M. Valpuesta Victor Muñoz
author_facet	Luis A. Campos Rajendra Sharma Sara Alvira Federico M. Ruiz Beatriz Ibarra-Molero Mourad Sadqi Carlos Alfonso Germán Rivas Jose M. Sanchez-Ruiz Antonio Romero Garrido José M. Valpuesta Victor Muñoz
author_sort	Luis A. Campos
title	Engineering protein assemblies with allosteric control via monomer fold-switching
title_short	Engineering protein assemblies with allosteric control via monomer fold-switching
title_full	Engineering protein assemblies with allosteric control via monomer fold-switching
title_fullStr	Engineering protein assemblies with allosteric control via monomer fold-switching
title_full_unstemmed	Engineering protein assemblies with allosteric control via monomer fold-switching
title_sort	engineering protein assemblies with allosteric control via monomer fold-switching
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/35fa5f2626334f038b8530ed1e35e4fe
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Engineering protein assemblies with allosteric control via monomer fold-switching

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