Engineering protein assemblies with allosteric control via monomer fold-switching
The design of protein assemblies is a major thrust for biomolecular engineering and nanobiotechnology. Here the authors demonstrate a general mechanism for designing allosteric macromolecular assemblies and showcase a proof of concept for engineered allosteric protein assembly.
Saved in:
Main Authors: | Luis A. Campos, Rajendra Sharma, Sara Alvira, Federico M. Ruiz, Beatriz Ibarra-Molero, Mourad Sadqi, Carlos Alfonso, Germán Rivas, Jose M. Sanchez-Ruiz, Antonio Romero Garrido, José M. Valpuesta, Victor Muñoz |
---|---|
Format: | article |
Language: | EN |
Published: |
Nature Portfolio
2019
|
Subjects: | |
Online Access: | https://doaj.org/article/35fa5f2626334f038b8530ed1e35e4fe |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Similar Items
-
Epistasis shapes the fitness landscape of an allosteric specificity switch
by: Kyle K. Nishikawa, et al.
Published: (2021) -
A substrate-driven allosteric switch that enhances PDI catalytic activity
by: Roelof H. Bekendam, et al.
Published: (2016) -
Accurate prediction of cellular co-translational folding indicates proteins can switch from post- to co-translational folding
by: Daniel A. Nissley, et al.
Published: (2016) -
Genomic RNA folding mediates assembly of human parechovirus
by: Shabih Shakeel, et al.
Published: (2017) -
Protein S-sulfenylation is a fleeting molecular switch that regulates non-enzymatic oxidative folding
by: Amy E. M. Beedle, et al.
Published: (2016)