Engineering protein assemblies with allosteric control via monomer fold-switching

The design of protein assemblies is a major thrust for biomolecular engineering and nanobiotechnology. Here the authors demonstrate a general mechanism for designing allosteric macromolecular assemblies and showcase a proof of concept for engineered allosteric protein assembly.

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Bibliographic Details
Main Authors: Luis A. Campos, Rajendra Sharma, Sara Alvira, Federico M. Ruiz, Beatriz Ibarra-Molero, Mourad Sadqi, Carlos Alfonso, Germán Rivas, Jose M. Sanchez-Ruiz, Antonio Romero Garrido, José M. Valpuesta, Victor Muñoz
Format: article
Language:EN
Published: Nature Portfolio 2019
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Online Access:https://doaj.org/article/35fa5f2626334f038b8530ed1e35e4fe
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