Nanostructure-specific X-ray tomography reveals myelin levels, integrity and axon orientations in mouse and human nervous tissue

Nanostructure-specific X-ray tomography reveals myelin levels, integrity and axon orientations in mouse and human nervous tissue

Small-angle X-ray scattering (SAXS) combines the high tissue penetration of X-rays with specificity to periodic nanostructures. The authors use SAXS tensor tomography (SAXS-TT) on intact mouse and human brain tissue samples, to quantify myelin levels and determine myelin integrity, myelinated axon o...

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Autores principales: Marios Georgiadis, Aileen Schroeter, Zirui Gao, Manuel Guizar-Sicairos, Marianne Liebi, Christoph Leuze, Jennifer A. McNab, Aleezah Balolia, Jelle Veraart, Benjamin Ades-Aron, Sunglyoung Kim, Timothy Shepherd, Choong H. Lee, Piotr Walczak, Shirish Chodankar, Phillip DiGiacomo, Gergely David, Mark Augath, Valerio Zerbi, Stefan Sommer, Ivan Rajkovic, Thomas Weiss, Oliver Bunk, Lin Yang, Jiangyang Zhang, Dmitry S. Novikov, Michael Zeineh, Els Fieremans, Markus Rudin
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Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/35fab30941ac43ca99ab4a14e671a883
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spelling oai:doaj.org-article:35fab30941ac43ca99ab4a14e671a8832021-12-02T14:58:43ZNanostructure-specific X-ray tomography reveals myelin levels, integrity and axon orientations in mouse and human nervous tissue10.1038/s41467-021-22719-72041-1723https://doaj.org/article/35fab30941ac43ca99ab4a14e671a8832021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22719-7https://doaj.org/toc/2041-1723Small-angle X-ray scattering (SAXS) combines the high tissue penetration of X-rays with specificity to periodic nanostructures. The authors use SAXS tensor tomography (SAXS-TT) on intact mouse and human brain tissue samples, to quantify myelin levels and determine myelin integrity, myelinated axon orientation, and fibre tracts non-destructively.Marios GeorgiadisAileen SchroeterZirui GaoManuel Guizar-SicairosMarianne LiebiChristoph LeuzeJennifer A. McNabAleezah BaloliaJelle VeraartBenjamin Ades-AronSunglyoung KimTimothy ShepherdChoong H. LeePiotr WalczakShirish ChodankarPhillip DiGiacomoGergely DavidMark AugathValerio ZerbiStefan SommerIvan RajkovicThomas WeissOliver BunkLin YangJiangyang ZhangDmitry S. NovikovMichael ZeinehEls FieremansMarkus RudinNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Marios Georgiadis
Aileen Schroeter
Zirui Gao
Manuel Guizar-Sicairos
Marianne Liebi
Christoph Leuze
Jennifer A. McNab
Aleezah Balolia
Jelle Veraart
Benjamin Ades-Aron
Sunglyoung Kim
Timothy Shepherd
Choong H. Lee
Piotr Walczak
Shirish Chodankar
Phillip DiGiacomo
Gergely David
Mark Augath
Valerio Zerbi
Stefan Sommer
Ivan Rajkovic
Thomas Weiss
Oliver Bunk
Lin Yang
Jiangyang Zhang
Dmitry S. Novikov
Michael Zeineh
Els Fieremans
Markus Rudin
Nanostructure-specific X-ray tomography reveals myelin levels, integrity and axon orientations in mouse and human nervous tissue
description Small-angle X-ray scattering (SAXS) combines the high tissue penetration of X-rays with specificity to periodic nanostructures. The authors use SAXS tensor tomography (SAXS-TT) on intact mouse and human brain tissue samples, to quantify myelin levels and determine myelin integrity, myelinated axon orientation, and fibre tracts non-destructively.
format article
author Marios Georgiadis
Aileen Schroeter
Zirui Gao
Manuel Guizar-Sicairos
Marianne Liebi
Christoph Leuze
Jennifer A. McNab
Aleezah Balolia
Jelle Veraart
Benjamin Ades-Aron
Sunglyoung Kim
Timothy Shepherd
Choong H. Lee
Piotr Walczak
Shirish Chodankar
Phillip DiGiacomo
Gergely David
Mark Augath
Valerio Zerbi
Stefan Sommer
Ivan Rajkovic
Thomas Weiss
Oliver Bunk
Lin Yang
Jiangyang Zhang
Dmitry S. Novikov
Michael Zeineh
Els Fieremans
Markus Rudin
author_facet Marios Georgiadis
Aileen Schroeter
Zirui Gao
Manuel Guizar-Sicairos
Marianne Liebi
Christoph Leuze
Jennifer A. McNab
Aleezah Balolia
Jelle Veraart
Benjamin Ades-Aron
Sunglyoung Kim
Timothy Shepherd
Choong H. Lee
Piotr Walczak
Shirish Chodankar
Phillip DiGiacomo
Gergely David
Mark Augath
Valerio Zerbi
Stefan Sommer
Ivan Rajkovic
Thomas Weiss
Oliver Bunk
Lin Yang
Jiangyang Zhang
Dmitry S. Novikov
Michael Zeineh
Els Fieremans
Markus Rudin
author_sort Marios Georgiadis
title Nanostructure-specific X-ray tomography reveals myelin levels, integrity and axon orientations in mouse and human nervous tissue
title_short Nanostructure-specific X-ray tomography reveals myelin levels, integrity and axon orientations in mouse and human nervous tissue
title_full Nanostructure-specific X-ray tomography reveals myelin levels, integrity and axon orientations in mouse and human nervous tissue
title_fullStr Nanostructure-specific X-ray tomography reveals myelin levels, integrity and axon orientations in mouse and human nervous tissue
title_full_unstemmed Nanostructure-specific X-ray tomography reveals myelin levels, integrity and axon orientations in mouse and human nervous tissue
title_sort nanostructure-specific x-ray tomography reveals myelin levels, integrity and axon orientations in mouse and human nervous tissue
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/35fab30941ac43ca99ab4a14e671a883
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