Two-stage electro–mechanical coupling of a KV channel in voltage-dependent activation

Two-stage electro–mechanical coupling of a KV channel in voltage-dependent activation

In voltage-gated potassium (KV) channels, the voltage-sensing domain (VSD) undergoes activation states to trigger pore opening via electro–mechanical (E–M) coupling. Here authors show that KV7.1 undergoes a two-stage E–M coupling mechanism during voltage-dependent activation.

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Autores principales: Panpan Hou, Po Wei Kang, Audrey Deyawe Kongmeneck, Nien-Du Yang, Yongfeng Liu, Jingyi Shi, Xianjin Xu, Kelli McFarland White, Mark A. Zaydman, Marina A. Kasimova, Guiscard Seebohm, Ling Zhong, Xiaoqin Zou, Mounir Tarek, Jianmin Cui
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/35fb6ed5769147e193c27d6349310d60
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spelling oai:doaj.org-article:35fb6ed5769147e193c27d6349310d602021-12-02T15:37:13ZTwo-stage electro–mechanical coupling of a KV channel in voltage-dependent activation10.1038/s41467-020-14406-w2041-1723https://doaj.org/article/35fb6ed5769147e193c27d6349310d602020-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-14406-whttps://doaj.org/toc/2041-1723In voltage-gated potassium (KV) channels, the voltage-sensing domain (VSD) undergoes activation states to trigger pore opening via electro–mechanical (E–M) coupling. Here authors show that KV7.1 undergoes a two-stage E–M coupling mechanism during voltage-dependent activation.Panpan HouPo Wei KangAudrey Deyawe KongmeneckNien-Du YangYongfeng LiuJingyi ShiXianjin XuKelli McFarland WhiteMark A. ZaydmanMarina A. KasimovaGuiscard SeebohmLing ZhongXiaoqin ZouMounir TarekJianmin CuiNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Panpan Hou
Po Wei Kang
Audrey Deyawe Kongmeneck
Nien-Du Yang
Yongfeng Liu
Jingyi Shi
Xianjin Xu
Kelli McFarland White
Mark A. Zaydman
Marina A. Kasimova
Guiscard Seebohm
Ling Zhong
Xiaoqin Zou
Mounir Tarek
Jianmin Cui
Two-stage electro–mechanical coupling of a KV channel in voltage-dependent activation
description In voltage-gated potassium (KV) channels, the voltage-sensing domain (VSD) undergoes activation states to trigger pore opening via electro–mechanical (E–M) coupling. Here authors show that KV7.1 undergoes a two-stage E–M coupling mechanism during voltage-dependent activation.
format article
author Panpan Hou
Po Wei Kang
Audrey Deyawe Kongmeneck
Nien-Du Yang
Yongfeng Liu
Jingyi Shi
Xianjin Xu
Kelli McFarland White
Mark A. Zaydman
Marina A. Kasimova
Guiscard Seebohm
Ling Zhong
Xiaoqin Zou
Mounir Tarek
Jianmin Cui
author_facet Panpan Hou
Po Wei Kang
Audrey Deyawe Kongmeneck
Nien-Du Yang
Yongfeng Liu
Jingyi Shi
Xianjin Xu
Kelli McFarland White
Mark A. Zaydman
Marina A. Kasimova
Guiscard Seebohm
Ling Zhong
Xiaoqin Zou
Mounir Tarek
Jianmin Cui
author_sort Panpan Hou
title Two-stage electro–mechanical coupling of a KV channel in voltage-dependent activation
title_short Two-stage electro–mechanical coupling of a KV channel in voltage-dependent activation
title_full Two-stage electro–mechanical coupling of a KV channel in voltage-dependent activation
title_fullStr Two-stage electro–mechanical coupling of a KV channel in voltage-dependent activation
title_full_unstemmed Two-stage electro–mechanical coupling of a KV channel in voltage-dependent activation
title_sort two-stage electro–mechanical coupling of a kv channel in voltage-dependent activation
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/35fb6ed5769147e193c27d6349310d60
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