High-resolution epitope mapping and characterization of SARS-CoV-2 antibodies in large cohorts of subjects with COVID-19

Using a high throughput, random bacterial peptide display approach applied to patient serum samples, Haynes, Kamath, Bozekowski et al identify the antigens and epitopes that elicit a SARS-CoV-2 humoral response. They identify differences depending on disease severity and further in silico analysis s...

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Autores principales:	Winston A. Haynes, Kathy Kamath, Joel Bozekowski, Elisabeth Baum-Jones, Melissa Campbell, Arnau Casanovas-Massana, Patrick S. Daugherty, Charles S. Dela Cruz, Abhilash Dhal, Shelli F. Farhadian, Lynn Fitzgibbons, John Fournier, Michael Jhatro, Gregory Jordan, Jon Klein, Carolina Lucas, Debra Kessler, Larry L. Luchsinger, Brian Martinez, M. Catherine Muenker, Lauren Pischel, Jack Reifert, Jaymie R. Sawyer, Rebecca Waitz, Elsio A. Wunder, Minlu Zhang, Yale IMPACT Team, Akiko Iwasaki, Albert Ko, John C. Shon
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/35fd28046b3d4061a1a0e849a204b9bb
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spelling	oai:doaj.org-article:35fd28046b3d4061a1a0e849a204b9bb2021-11-28T12:10:25ZHigh-resolution epitope mapping and characterization of SARS-CoV-2 antibodies in large cohorts of subjects with COVID-1910.1038/s42003-021-02835-22399-3642https://doaj.org/article/35fd28046b3d4061a1a0e849a204b9bb2021-11-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02835-2https://doaj.org/toc/2399-3642Using a high throughput, random bacterial peptide display approach applied to patient serum samples, Haynes, Kamath, Bozekowski et al identify the antigens and epitopes that elicit a SARS-CoV-2 humoral response. They identify differences depending on disease severity and further in silico analysis suggests decreased epitope signal for Q677P but not for D614G mutant SARSCoV-2 strains.Winston A. HaynesKathy KamathJoel BozekowskiElisabeth Baum-JonesMelissa CampbellArnau Casanovas-MassanaPatrick S. DaughertyCharles S. Dela CruzAbhilash DhalShelli F. FarhadianLynn FitzgibbonsJohn FournierMichael JhatroGregory JordanJon KleinCarolina LucasDebra KesslerLarry L. LuchsingerBrian MartinezM. Catherine MuenkerLauren PischelJack ReifertJaymie R. SawyerRebecca WaitzElsio A. WunderMinlu ZhangYale IMPACT TeamAkiko IwasakiAlbert KoJohn C. ShonNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Winston A. Haynes Kathy Kamath Joel Bozekowski Elisabeth Baum-Jones Melissa Campbell Arnau Casanovas-Massana Patrick S. Daugherty Charles S. Dela Cruz Abhilash Dhal Shelli F. Farhadian Lynn Fitzgibbons John Fournier Michael Jhatro Gregory Jordan Jon Klein Carolina Lucas Debra Kessler Larry L. Luchsinger Brian Martinez M. Catherine Muenker Lauren Pischel Jack Reifert Jaymie R. Sawyer Rebecca Waitz Elsio A. Wunder Minlu Zhang Yale IMPACT Team Akiko Iwasaki Albert Ko John C. Shon High-resolution epitope mapping and characterization of SARS-CoV-2 antibodies in large cohorts of subjects with COVID-19
description	Using a high throughput, random bacterial peptide display approach applied to patient serum samples, Haynes, Kamath, Bozekowski et al identify the antigens and epitopes that elicit a SARS-CoV-2 humoral response. They identify differences depending on disease severity and further in silico analysis suggests decreased epitope signal for Q677P but not for D614G mutant SARSCoV-2 strains.
format	article
author	Winston A. Haynes Kathy Kamath Joel Bozekowski Elisabeth Baum-Jones Melissa Campbell Arnau Casanovas-Massana Patrick S. Daugherty Charles S. Dela Cruz Abhilash Dhal Shelli F. Farhadian Lynn Fitzgibbons John Fournier Michael Jhatro Gregory Jordan Jon Klein Carolina Lucas Debra Kessler Larry L. Luchsinger Brian Martinez M. Catherine Muenker Lauren Pischel Jack Reifert Jaymie R. Sawyer Rebecca Waitz Elsio A. Wunder Minlu Zhang Yale IMPACT Team Akiko Iwasaki Albert Ko John C. Shon
author_facet	Winston A. Haynes Kathy Kamath Joel Bozekowski Elisabeth Baum-Jones Melissa Campbell Arnau Casanovas-Massana Patrick S. Daugherty Charles S. Dela Cruz Abhilash Dhal Shelli F. Farhadian Lynn Fitzgibbons John Fournier Michael Jhatro Gregory Jordan Jon Klein Carolina Lucas Debra Kessler Larry L. Luchsinger Brian Martinez M. Catherine Muenker Lauren Pischel Jack Reifert Jaymie R. Sawyer Rebecca Waitz Elsio A. Wunder Minlu Zhang Yale IMPACT Team Akiko Iwasaki Albert Ko John C. Shon
author_sort	Winston A. Haynes
title	High-resolution epitope mapping and characterization of SARS-CoV-2 antibodies in large cohorts of subjects with COVID-19
title_short	High-resolution epitope mapping and characterization of SARS-CoV-2 antibodies in large cohorts of subjects with COVID-19
title_full	High-resolution epitope mapping and characterization of SARS-CoV-2 antibodies in large cohorts of subjects with COVID-19
title_fullStr	High-resolution epitope mapping and characterization of SARS-CoV-2 antibodies in large cohorts of subjects with COVID-19
title_full_unstemmed	High-resolution epitope mapping and characterization of SARS-CoV-2 antibodies in large cohorts of subjects with COVID-19
title_sort	high-resolution epitope mapping and characterization of sars-cov-2 antibodies in large cohorts of subjects with covid-19
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/35fd28046b3d4061a1a0e849a204b9bb
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High-resolution epitope mapping and characterization of SARS-CoV-2 antibodies in large cohorts of subjects with COVID-19

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