Hydrothermal synthesis of hydroxyapatite powders using Response Surface Methodology (RSM).

Hydroxyapatite (HAp)-[Ca10 (PO4)6(OH) 2] has a similar chemical composition to bone material, making it the main mineral supplement in bone-making. Due to its high biocompatibility, hydroxyapatite is widely used in the repair of bone deficiencies and in the production of dental or orthopedic implant...

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Autores principales:	Shamsi Ebrahimi, Coswald Stephen Sipaut Mohd Nasri, Sazmal Effendi Bin Arshad
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/35ffe21e68954f358c4276f0ef62d690
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spelling	oai:doaj.org-article:35ffe21e68954f358c4276f0ef62d6902021-12-02T20:03:59ZHydrothermal synthesis of hydroxyapatite powders using Response Surface Methodology (RSM).1932-620310.1371/journal.pone.0251009https://doaj.org/article/35ffe21e68954f358c4276f0ef62d6902021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0251009https://doaj.org/toc/1932-6203Hydroxyapatite (HAp)-[Ca10 (PO4)6(OH) 2] has a similar chemical composition to bone material, making it the main mineral supplement in bone-making. Due to its high biocompatibility, hydroxyapatite is widely used in the repair of bone deficiencies and in the production of dental or orthopedic implants. In this research, hydroxyapatite nanopowder was synthesized using a hydrothermal technique. Fourier Transform Infrared Spectroscopy (FTIR) and transmission electron microscopy (TEM) were used to investigate the chemical structure and morphology of the synthesized hydroxyapatite powder. X-ray diffraction (XRD) was used to evaluate the phase analysis of HAp nanopowder. In addition, bioactivity HAp assessment was conducted by scanning electron microscopy (SEM) attached with Energy Dispersive X-Ray Spectroscopy (EDX) analysis. Response Surface Methodology (RSM) with central composite design (CCD) was used in order to determine the optimal conditions for yield, size, and crystallinity. Three independent variables (pH, temperature, and hydrothermal treatment time) were investigated. The yield was observed to increase in alkaline conditions; pH showed the greatest influence on the yield, size, and crystallinity of the synthesized hydroxyapatite, based on Analysis of Variance. The results of bioactivity evaluation are showed high bioactivity due to the formation of apatite on the surface of the synthesized nanopowder.Shamsi EbrahimiCoswald Stephen Sipaut Mohd NasriSazmal Effendi Bin ArshadPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 5, p e0251009 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Shamsi Ebrahimi Coswald Stephen Sipaut Mohd Nasri Sazmal Effendi Bin Arshad Hydrothermal synthesis of hydroxyapatite powders using Response Surface Methodology (RSM).
description	Hydroxyapatite (HAp)-[Ca10 (PO4)6(OH) 2] has a similar chemical composition to bone material, making it the main mineral supplement in bone-making. Due to its high biocompatibility, hydroxyapatite is widely used in the repair of bone deficiencies and in the production of dental or orthopedic implants. In this research, hydroxyapatite nanopowder was synthesized using a hydrothermal technique. Fourier Transform Infrared Spectroscopy (FTIR) and transmission electron microscopy (TEM) were used to investigate the chemical structure and morphology of the synthesized hydroxyapatite powder. X-ray diffraction (XRD) was used to evaluate the phase analysis of HAp nanopowder. In addition, bioactivity HAp assessment was conducted by scanning electron microscopy (SEM) attached with Energy Dispersive X-Ray Spectroscopy (EDX) analysis. Response Surface Methodology (RSM) with central composite design (CCD) was used in order to determine the optimal conditions for yield, size, and crystallinity. Three independent variables (pH, temperature, and hydrothermal treatment time) were investigated. The yield was observed to increase in alkaline conditions; pH showed the greatest influence on the yield, size, and crystallinity of the synthesized hydroxyapatite, based on Analysis of Variance. The results of bioactivity evaluation are showed high bioactivity due to the formation of apatite on the surface of the synthesized nanopowder.
format	article
author	Shamsi Ebrahimi Coswald Stephen Sipaut Mohd Nasri Sazmal Effendi Bin Arshad
author_facet	Shamsi Ebrahimi Coswald Stephen Sipaut Mohd Nasri Sazmal Effendi Bin Arshad
author_sort	Shamsi Ebrahimi
title	Hydrothermal synthesis of hydroxyapatite powders using Response Surface Methodology (RSM).
title_short	Hydrothermal synthesis of hydroxyapatite powders using Response Surface Methodology (RSM).
title_full	Hydrothermal synthesis of hydroxyapatite powders using Response Surface Methodology (RSM).
title_fullStr	Hydrothermal synthesis of hydroxyapatite powders using Response Surface Methodology (RSM).
title_full_unstemmed	Hydrothermal synthesis of hydroxyapatite powders using Response Surface Methodology (RSM).
title_sort	hydrothermal synthesis of hydroxyapatite powders using response surface methodology (rsm).
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/35ffe21e68954f358c4276f0ef62d690
work_keys_str_mv	AT shamsiebrahimi hydrothermalsynthesisofhydroxyapatitepowdersusingresponsesurfacemethodologyrsm AT coswaldstephensipautmohdnasri hydrothermalsynthesisofhydroxyapatitepowdersusingresponsesurfacemethodologyrsm AT sazmaleffendibinarshad hydrothermalsynthesisofhydroxyapatitepowdersusingresponsesurfacemethodologyrsm
_version_	1718375594033414144

Hydrothermal synthesis of hydroxyapatite powders using Response Surface Methodology (RSM).

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