The impact of extraction protocol on the chemical profile of cannabis extracts from a single cultivar

Abstract The last two decades have seen a dramatic shift in cannabis legislation around the world. Cannabis products are now widely available and commercial production and use of phytocannabinoid products is rapidly growing. However, this growth is outpacing the research needed to elucidate the ther...

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Autores principales:	Janina K. Bowen, Jacqueline M. Chaparro, Alexander M. McCorkle, Edward Palumbo, Jessica E. Prenni
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/360085723f2e48e1846254e3c80386ec
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spelling	oai:doaj.org-article:360085723f2e48e1846254e3c80386ec2021-11-14T12:23:03ZThe impact of extraction protocol on the chemical profile of cannabis extracts from a single cultivar10.1038/s41598-021-01378-02045-2322https://doaj.org/article/360085723f2e48e1846254e3c80386ec2021-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-01378-0https://doaj.org/toc/2045-2322Abstract The last two decades have seen a dramatic shift in cannabis legislation around the world. Cannabis products are now widely available and commercial production and use of phytocannabinoid products is rapidly growing. However, this growth is outpacing the research needed to elucidate the therapeutic efficacy of the myriad of chemical compounds found primarily in the flower of the female cannabis plant. This lack of research and corresponding regulation has resulted in processing methods, products, and terminology that are variable and confusing for consumers. Importantly, the impact of processing methods on the resulting chemical profile of full spectrum cannabis extracts is not well understood. As a first step in addressing this knowledge gap we have utilized a combination of analytical approaches to characterize the broad chemical composition of a single cannabis cultivar that was processed using previously optimized and commonly used commercial extraction protocols including alcoholic solvents and super critical carbon dioxide. Significant variation in the bioactive chemical profile was observed in the extracts resulting from the different protocols demonstrating the need for further research regarding the influence of processing on therapeutic efficacy as well as the importance of labeling in the marketing of multi-component cannabis products.Janina K. BowenJacqueline M. ChaparroAlexander M. McCorkleEdward PalumboJessica E. PrenniNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Janina K. Bowen Jacqueline M. Chaparro Alexander M. McCorkle Edward Palumbo Jessica E. Prenni The impact of extraction protocol on the chemical profile of cannabis extracts from a single cultivar
description	Abstract The last two decades have seen a dramatic shift in cannabis legislation around the world. Cannabis products are now widely available and commercial production and use of phytocannabinoid products is rapidly growing. However, this growth is outpacing the research needed to elucidate the therapeutic efficacy of the myriad of chemical compounds found primarily in the flower of the female cannabis plant. This lack of research and corresponding regulation has resulted in processing methods, products, and terminology that are variable and confusing for consumers. Importantly, the impact of processing methods on the resulting chemical profile of full spectrum cannabis extracts is not well understood. As a first step in addressing this knowledge gap we have utilized a combination of analytical approaches to characterize the broad chemical composition of a single cannabis cultivar that was processed using previously optimized and commonly used commercial extraction protocols including alcoholic solvents and super critical carbon dioxide. Significant variation in the bioactive chemical profile was observed in the extracts resulting from the different protocols demonstrating the need for further research regarding the influence of processing on therapeutic efficacy as well as the importance of labeling in the marketing of multi-component cannabis products.
format	article
author	Janina K. Bowen Jacqueline M. Chaparro Alexander M. McCorkle Edward Palumbo Jessica E. Prenni
author_facet	Janina K. Bowen Jacqueline M. Chaparro Alexander M. McCorkle Edward Palumbo Jessica E. Prenni
author_sort	Janina K. Bowen
title	The impact of extraction protocol on the chemical profile of cannabis extracts from a single cultivar
title_short	The impact of extraction protocol on the chemical profile of cannabis extracts from a single cultivar
title_full	The impact of extraction protocol on the chemical profile of cannabis extracts from a single cultivar
title_fullStr	The impact of extraction protocol on the chemical profile of cannabis extracts from a single cultivar
title_full_unstemmed	The impact of extraction protocol on the chemical profile of cannabis extracts from a single cultivar
title_sort	impact of extraction protocol on the chemical profile of cannabis extracts from a single cultivar
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/360085723f2e48e1846254e3c80386ec
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The impact of extraction protocol on the chemical profile of cannabis extracts from a single cultivar

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