HHEX is a transcriptional regulator of the VEGFC/FLT4/PROX1 signaling axis during vascular development

VEGFC, its receptor FLT4, and transcriptional effector PROX1 control formation of the lymphatic system but how is unclear. Here, the authors show that the transcription factor hematopoietically expressed homeobox (HHEX) regulates VEGFC, FLT4 and PROX1 in fish and mammals during angiogenic sprouting...

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Autores principales:	Sébastien Gauvrit, Alethia Villasenor, Boris Strilic, Philip Kitchen, Michelle M. Collins, Rubén Marín-Juez, Stefan Guenther, Hans-Martin Maischein, Nana Fukuda, Maurice A. Canham, Joshua M. Brickman, Clifford W. Bogue, Padma-Sheela Jayaraman, Didier Y. R. Stainier
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3601d02f4c94462c8cb4148709279b67
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spelling	oai:doaj.org-article:3601d02f4c94462c8cb4148709279b672021-12-02T17:31:30ZHHEX is a transcriptional regulator of the VEGFC/FLT4/PROX1 signaling axis during vascular development10.1038/s41467-018-05039-12041-1723https://doaj.org/article/3601d02f4c94462c8cb4148709279b672018-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05039-1https://doaj.org/toc/2041-1723VEGFC, its receptor FLT4, and transcriptional effector PROX1 control formation of the lymphatic system but how is unclear. Here, the authors show that the transcription factor hematopoietically expressed homeobox (HHEX) regulates VEGFC, FLT4 and PROX1 in fish and mammals during angiogenic sprouting and lymphatic formation.Sébastien GauvritAlethia VillasenorBoris StrilicPhilip KitchenMichelle M. CollinsRubén Marín-JuezStefan GuentherHans-Martin MaischeinNana FukudaMaurice A. CanhamJoshua M. BrickmanClifford W. BoguePadma-Sheela JayaramanDidier Y. R. StainierNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Sébastien Gauvrit Alethia Villasenor Boris Strilic Philip Kitchen Michelle M. Collins Rubén Marín-Juez Stefan Guenther Hans-Martin Maischein Nana Fukuda Maurice A. Canham Joshua M. Brickman Clifford W. Bogue Padma-Sheela Jayaraman Didier Y. R. Stainier HHEX is a transcriptional regulator of the VEGFC/FLT4/PROX1 signaling axis during vascular development
description	VEGFC, its receptor FLT4, and transcriptional effector PROX1 control formation of the lymphatic system but how is unclear. Here, the authors show that the transcription factor hematopoietically expressed homeobox (HHEX) regulates VEGFC, FLT4 and PROX1 in fish and mammals during angiogenic sprouting and lymphatic formation.
format	article
author	Sébastien Gauvrit Alethia Villasenor Boris Strilic Philip Kitchen Michelle M. Collins Rubén Marín-Juez Stefan Guenther Hans-Martin Maischein Nana Fukuda Maurice A. Canham Joshua M. Brickman Clifford W. Bogue Padma-Sheela Jayaraman Didier Y. R. Stainier
author_facet	Sébastien Gauvrit Alethia Villasenor Boris Strilic Philip Kitchen Michelle M. Collins Rubén Marín-Juez Stefan Guenther Hans-Martin Maischein Nana Fukuda Maurice A. Canham Joshua M. Brickman Clifford W. Bogue Padma-Sheela Jayaraman Didier Y. R. Stainier
author_sort	Sébastien Gauvrit
title	HHEX is a transcriptional regulator of the VEGFC/FLT4/PROX1 signaling axis during vascular development
title_short	HHEX is a transcriptional regulator of the VEGFC/FLT4/PROX1 signaling axis during vascular development
title_full	HHEX is a transcriptional regulator of the VEGFC/FLT4/PROX1 signaling axis during vascular development
title_fullStr	HHEX is a transcriptional regulator of the VEGFC/FLT4/PROX1 signaling axis during vascular development
title_full_unstemmed	HHEX is a transcriptional regulator of the VEGFC/FLT4/PROX1 signaling axis during vascular development
title_sort	hhex is a transcriptional regulator of the vegfc/flt4/prox1 signaling axis during vascular development
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/3601d02f4c94462c8cb4148709279b67
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HHEX is a transcriptional regulator of the VEGFC/FLT4/PROX1 signaling axis during vascular development

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