Stem cell proliferation is induced by apoptotic bodies from dying cells during epithelial tissue maintenance

Damaged epithelial tissues are known to compensate for cell death through compensatory cell divisions to maintain epithelial integrity. Here, the authors show in living epithelia that dying cells stimulate adjacent stem cells to divide through caspase-dependent production of Wnt8a-containing apoptot...

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Autores principales:	Courtney K. Brock, Stephen T. Wallin, Oscar E. Ruiz, Krystin M. Samms, Amrita Mandal, Elizabeth A. Sumner, George T. Eisenhoffer
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/36038ed7967345729d64f073b9d12a1c
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spelling	oai:doaj.org-article:36038ed7967345729d64f073b9d12a1c2021-12-02T14:39:59ZStem cell proliferation is induced by apoptotic bodies from dying cells during epithelial tissue maintenance10.1038/s41467-019-09010-62041-1723https://doaj.org/article/36038ed7967345729d64f073b9d12a1c2019-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09010-6https://doaj.org/toc/2041-1723Damaged epithelial tissues are known to compensate for cell death through compensatory cell divisions to maintain epithelial integrity. Here, the authors show in living epithelia that dying cells stimulate adjacent stem cells to divide through caspase-dependent production of Wnt8a-containing apoptotic bodies.Courtney K. BrockStephen T. WallinOscar E. RuizKrystin M. SammsAmrita MandalElizabeth A. SumnerGeorge T. EisenhofferNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Courtney K. Brock Stephen T. Wallin Oscar E. Ruiz Krystin M. Samms Amrita Mandal Elizabeth A. Sumner George T. Eisenhoffer Stem cell proliferation is induced by apoptotic bodies from dying cells during epithelial tissue maintenance
description	Damaged epithelial tissues are known to compensate for cell death through compensatory cell divisions to maintain epithelial integrity. Here, the authors show in living epithelia that dying cells stimulate adjacent stem cells to divide through caspase-dependent production of Wnt8a-containing apoptotic bodies.
format	article
author	Courtney K. Brock Stephen T. Wallin Oscar E. Ruiz Krystin M. Samms Amrita Mandal Elizabeth A. Sumner George T. Eisenhoffer
author_facet	Courtney K. Brock Stephen T. Wallin Oscar E. Ruiz Krystin M. Samms Amrita Mandal Elizabeth A. Sumner George T. Eisenhoffer
author_sort	Courtney K. Brock
title	Stem cell proliferation is induced by apoptotic bodies from dying cells during epithelial tissue maintenance
title_short	Stem cell proliferation is induced by apoptotic bodies from dying cells during epithelial tissue maintenance
title_full	Stem cell proliferation is induced by apoptotic bodies from dying cells during epithelial tissue maintenance
title_fullStr	Stem cell proliferation is induced by apoptotic bodies from dying cells during epithelial tissue maintenance
title_full_unstemmed	Stem cell proliferation is induced by apoptotic bodies from dying cells during epithelial tissue maintenance
title_sort	stem cell proliferation is induced by apoptotic bodies from dying cells during epithelial tissue maintenance
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/36038ed7967345729d64f073b9d12a1c
work_keys_str_mv	AT courtneykbrock stemcellproliferationisinducedbyapoptoticbodiesfromdyingcellsduringepithelialtissuemaintenance AT stephentwallin stemcellproliferationisinducedbyapoptoticbodiesfromdyingcellsduringepithelialtissuemaintenance AT oscareruiz stemcellproliferationisinducedbyapoptoticbodiesfromdyingcellsduringepithelialtissuemaintenance AT krystinmsamms stemcellproliferationisinducedbyapoptoticbodiesfromdyingcellsduringepithelialtissuemaintenance AT amritamandal stemcellproliferationisinducedbyapoptoticbodiesfromdyingcellsduringepithelialtissuemaintenance AT elizabethasumner stemcellproliferationisinducedbyapoptoticbodiesfromdyingcellsduringepithelialtissuemaintenance AT georgeteisenhoffer stemcellproliferationisinducedbyapoptoticbodiesfromdyingcellsduringepithelialtissuemaintenance
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Stem cell proliferation is induced by apoptotic bodies from dying cells during epithelial tissue maintenance

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