Intra-day variations of blood reelin levels in healthy individuals

Introduction Reelin (RELN) is an extracellular glycoprotein best known to be crucial for neuronal migration during the embryonic period and regulation of synaptic plasticity in the adult brain, with recent studies pointing to reelin playing an important part in the organization of peripheral organs...

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Autores principales:	Lukas Sturm, Ludger Tebartz van Elst, Bernd Fiebich, Martin Wolkewitz, Tobias Hornig
Formato:	article
Lenguaje:	EN
Publicado:	Termedia Publishing House 2019
Materias:	blood serum variations reelin time-dependent day enzyme-linked immunosorbent assay fluctuations Medicine R
Acceso en línea:	https://doaj.org/article/36044ab299fd4ea4bad4dd075c0eb32b
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spelling	oai:doaj.org-article:36044ab299fd4ea4bad4dd075c0eb32b2021-12-02T18:33:05ZIntra-day variations of blood reelin levels in healthy individuals1734-19221896-915110.5114/aoms.2020.91288https://doaj.org/article/36044ab299fd4ea4bad4dd075c0eb32b2019-12-01T00:00:00Zhttps://www.archivesofmedicalscience.com/Intra-day-variations-of-blood-reelin-levels-in-healthy-individuals,76325,0,2.htmlhttps://doaj.org/toc/1734-1922https://doaj.org/toc/1896-9151Introduction Reelin (RELN) is an extracellular glycoprotein best known to be crucial for neuronal migration during the embryonic period and regulation of synaptic plasticity in the adult brain, with recent studies pointing to reelin playing an important part in the organization of peripheral organs as well. Abnormalities in RELN function are associated with a variety of medical conditions in human beings. These alterations partly also reflect in RELN’s blood levels, which gives it a clinical relevance as a potential biomarker. Requirement for a possible clinical use is a profound understanding of RELN’s physiology. We hypothesized blood RELN levels could underlie time-dependent variations and therefore examined individuals’ serum reelin concentrations in the course of one day. Material and methods We obtained blood samples from healthy individuals (n = 10) at several times of measurement over a time period of 24 h. We subsequently determined the respective serum RELN concentrations utilizing an enzyme-linked immunosorbent assay and tested for intra- and interindividual variations in serum RELN concentrations over time. Results All tested individuals’ serum RELN levels displayed significant intraindividual variations in the course of 24 h. Test subjects’ reelin day profiles showed substantial divergence among each other. Conclusions Our findings point to short-term fluctuations in blood RELN levels being part of physiological RELN homeostasis. This is of special interest with regard to a potential clinical use of RELN as a biomarker.Lukas SturmLudger Tebartz van ElstBernd FiebichMartin WolkewitzTobias HornigTermedia Publishing Housearticlebloodserumvariationsreelintime-dependentdayenzyme-linked immunosorbent assayfluctuationsMedicineRENArchives of Medical Science, Vol 16, Iss 1, Pp 118-123 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	blood serum variations reelin time-dependent day enzyme-linked immunosorbent assay fluctuations Medicine R
spellingShingle	blood serum variations reelin time-dependent day enzyme-linked immunosorbent assay fluctuations Medicine R Lukas Sturm Ludger Tebartz van Elst Bernd Fiebich Martin Wolkewitz Tobias Hornig Intra-day variations of blood reelin levels in healthy individuals
description	Introduction Reelin (RELN) is an extracellular glycoprotein best known to be crucial for neuronal migration during the embryonic period and regulation of synaptic plasticity in the adult brain, with recent studies pointing to reelin playing an important part in the organization of peripheral organs as well. Abnormalities in RELN function are associated with a variety of medical conditions in human beings. These alterations partly also reflect in RELN’s blood levels, which gives it a clinical relevance as a potential biomarker. Requirement for a possible clinical use is a profound understanding of RELN’s physiology. We hypothesized blood RELN levels could underlie time-dependent variations and therefore examined individuals’ serum reelin concentrations in the course of one day. Material and methods We obtained blood samples from healthy individuals (n = 10) at several times of measurement over a time period of 24 h. We subsequently determined the respective serum RELN concentrations utilizing an enzyme-linked immunosorbent assay and tested for intra- and interindividual variations in serum RELN concentrations over time. Results All tested individuals’ serum RELN levels displayed significant intraindividual variations in the course of 24 h. Test subjects’ reelin day profiles showed substantial divergence among each other. Conclusions Our findings point to short-term fluctuations in blood RELN levels being part of physiological RELN homeostasis. This is of special interest with regard to a potential clinical use of RELN as a biomarker.
format	article
author	Lukas Sturm Ludger Tebartz van Elst Bernd Fiebich Martin Wolkewitz Tobias Hornig
author_facet	Lukas Sturm Ludger Tebartz van Elst Bernd Fiebich Martin Wolkewitz Tobias Hornig
author_sort	Lukas Sturm
title	Intra-day variations of blood reelin levels in healthy individuals
title_short	Intra-day variations of blood reelin levels in healthy individuals
title_full	Intra-day variations of blood reelin levels in healthy individuals
title_fullStr	Intra-day variations of blood reelin levels in healthy individuals
title_full_unstemmed	Intra-day variations of blood reelin levels in healthy individuals
title_sort	intra-day variations of blood reelin levels in healthy individuals
publisher	Termedia Publishing House
publishDate	2019
url	https://doaj.org/article/36044ab299fd4ea4bad4dd075c0eb32b
work_keys_str_mv	AT lukassturm intradayvariationsofbloodreelinlevelsinhealthyindividuals AT ludgertebartzvanelst intradayvariationsofbloodreelinlevelsinhealthyindividuals AT berndfiebich intradayvariationsofbloodreelinlevelsinhealthyindividuals AT martinwolkewitz intradayvariationsofbloodreelinlevelsinhealthyindividuals AT tobiashornig intradayvariationsofbloodreelinlevelsinhealthyindividuals
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Intra-day variations of blood reelin levels in healthy individuals

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