Characteristics of the mechanosensitive bladder afferent activities in relation with microcontractions in male rats with bladder outlet obstruction

Abstract We investigated the characteristics of bladder mechanosensitive single-unit afferent activities (SAAs) in rats with a bladder outlet obstruction (BOO) and their relationship with bladder microcontractions. Male Wistar rats were divided into Sham and BOO groups. Four or 10 days after the sur...

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Autores principales:	Naoki Aizawa, Koji Ichihara, Hiroshi Fukuhara, Tetsuya Fujimura, Karl-Erik Andersson, Yukio Homma, Yasuhiko Igawa
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/3604d977a04e443e8e20e99565975ae4
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spelling	oai:doaj.org-article:3604d977a04e443e8e20e99565975ae42021-12-02T15:05:52ZCharacteristics of the mechanosensitive bladder afferent activities in relation with microcontractions in male rats with bladder outlet obstruction10.1038/s41598-017-07898-y2045-2322https://doaj.org/article/3604d977a04e443e8e20e99565975ae42017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-07898-yhttps://doaj.org/toc/2045-2322Abstract We investigated the characteristics of bladder mechanosensitive single-unit afferent activities (SAAs) in rats with a bladder outlet obstruction (BOO) and their relationship with bladder microcontractions. Male Wistar rats were divided into Sham and BOO groups. Four or 10 days after the surgery, rats were anesthetized with urethane. The SAAs of Aδ- or C-fibers from the L6 dorsal roots were recorded during bladder filling. The BOO group showed a higher number of microcontractions and lower SAAs of Aδ-fibers compared with those of the Sham group. These findings were significant at day 10 post-operatively. In contrast, SAAs of C-fibers were not significantly different between the groups at either day 4 or 10. In the BOO group at day 10, the SAAs of both Aδ- and C-fibers at the “ascending” phase of microcontractions were significantly higher than those at the other phases (descending or stationary), and a similar tendency was also observed at day 4. Taken together, during bladder filling, the bladder mechanosensitive SAAs of Aδ-fibers were attenuated, but SAAs of both Aδ- and C-fibers were intermittently enhanced by propagation of microcontractions.Naoki AizawaKoji IchiharaHiroshi FukuharaTetsuya FujimuraKarl-Erik AnderssonYukio HommaYasuhiko IgawaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-8 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Naoki Aizawa Koji Ichihara Hiroshi Fukuhara Tetsuya Fujimura Karl-Erik Andersson Yukio Homma Yasuhiko Igawa Characteristics of the mechanosensitive bladder afferent activities in relation with microcontractions in male rats with bladder outlet obstruction
description	Abstract We investigated the characteristics of bladder mechanosensitive single-unit afferent activities (SAAs) in rats with a bladder outlet obstruction (BOO) and their relationship with bladder microcontractions. Male Wistar rats were divided into Sham and BOO groups. Four or 10 days after the surgery, rats were anesthetized with urethane. The SAAs of Aδ- or C-fibers from the L6 dorsal roots were recorded during bladder filling. The BOO group showed a higher number of microcontractions and lower SAAs of Aδ-fibers compared with those of the Sham group. These findings were significant at day 10 post-operatively. In contrast, SAAs of C-fibers were not significantly different between the groups at either day 4 or 10. In the BOO group at day 10, the SAAs of both Aδ- and C-fibers at the “ascending” phase of microcontractions were significantly higher than those at the other phases (descending or stationary), and a similar tendency was also observed at day 4. Taken together, during bladder filling, the bladder mechanosensitive SAAs of Aδ-fibers were attenuated, but SAAs of both Aδ- and C-fibers were intermittently enhanced by propagation of microcontractions.
format	article
author	Naoki Aizawa Koji Ichihara Hiroshi Fukuhara Tetsuya Fujimura Karl-Erik Andersson Yukio Homma Yasuhiko Igawa
author_facet	Naoki Aizawa Koji Ichihara Hiroshi Fukuhara Tetsuya Fujimura Karl-Erik Andersson Yukio Homma Yasuhiko Igawa
author_sort	Naoki Aizawa
title	Characteristics of the mechanosensitive bladder afferent activities in relation with microcontractions in male rats with bladder outlet obstruction
title_short	Characteristics of the mechanosensitive bladder afferent activities in relation with microcontractions in male rats with bladder outlet obstruction
title_full	Characteristics of the mechanosensitive bladder afferent activities in relation with microcontractions in male rats with bladder outlet obstruction
title_fullStr	Characteristics of the mechanosensitive bladder afferent activities in relation with microcontractions in male rats with bladder outlet obstruction
title_full_unstemmed	Characteristics of the mechanosensitive bladder afferent activities in relation with microcontractions in male rats with bladder outlet obstruction
title_sort	characteristics of the mechanosensitive bladder afferent activities in relation with microcontractions in male rats with bladder outlet obstruction
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/3604d977a04e443e8e20e99565975ae4
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Characteristics of the mechanosensitive bladder afferent activities in relation with microcontractions in male rats with bladder outlet obstruction

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