Deep-tissue localization of magnetic field hyperthermia using pulse sequencing

Objective Deep-tissue localization of thermal doses is a long-standing challenge in magnetic field hyperthermia (MFH), and remains a limitation of the clinical application of MFH to date. Here, we show that pulse sequencing of MFH leads to a more persistent inhibition of tumor growth and less system...

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Autores principales:	Felista L. Tansi, Wisdom O. Maduabuchi, Melanie Hirsch, Paul Southern, Simon Hattersley, Rainer Quaas, Ulf Teichgräber, Quentin A. Pankhurst, Ingrid Hilger
Formato:	article
Lenguaje:	EN
Publicado:	Taylor & Francis Group 2021
Materias:	pulse magnetic hyperthermia temperature oscillations intermittent hyperthermia pulsatile heating thermoablation Medical technology R855-855.5
Acceso en línea:	https://doaj.org/article/360575b57d59400c930b4c1f5a733fdf
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spelling	oai:doaj.org-article:360575b57d59400c930b4c1f5a733fdf2021-11-11T14:23:40ZDeep-tissue localization of magnetic field hyperthermia using pulse sequencing0265-67361464-515710.1080/02656736.2021.1912412https://doaj.org/article/360575b57d59400c930b4c1f5a733fdf2021-01-01T00:00:00Zhttp://dx.doi.org/10.1080/02656736.2021.1912412https://doaj.org/toc/0265-6736https://doaj.org/toc/1464-5157Objective Deep-tissue localization of thermal doses is a long-standing challenge in magnetic field hyperthermia (MFH), and remains a limitation of the clinical application of MFH to date. Here, we show that pulse sequencing of MFH leads to a more persistent inhibition of tumor growth and less systemic impact than continuous MFH, even when delivering the same thermal dose. Methods We used an in vivo orthotopic murine model of pancreatic PANC-1 cancer, which was designed with a view to the forthcoming ‘NoCanTher’ clinical study, and featured MFH alongside systemic chemotherapy (SyC: gemcitabine and nab-paclitaxel). In parallel, in silico thermal modelling was implemented. Results Tumor volumes 27 days after the start of MFH/SyC treatment were 53% (of the initial volume) in the pulse MFH group, compared to 136% in the continuous MFH group, and 337% in the non-treated controls. Systemically, pulse MFH led to ca. 50% less core-temperature increase in the mice for a given injected dose of magnetic heating agent, and inflicted lower levels of the stress marker, as seen in the blood-borne neutrophil-to-lymphocyte ratio (1.7, compared to 3.2 for continuous MFH + SyC, and 1.2 for controls). Conclusion Our data provided insights into the influence of pulse sequencing on the observed biological outcomes, and validated the nature of the improved thermal dose localization, alongside significant lowering of the overall energy expenditure entailed in the treatment.Felista L. TansiWisdom O. MaduabuchiMelanie HirschPaul SouthernSimon HattersleyRainer QuaasUlf TeichgräberQuentin A. PankhurstIngrid HilgerTaylor & Francis Grouparticlepulse magnetic hyperthermiatemperature oscillationsintermittent hyperthermiapulsatile heatingthermoablationMedical technologyR855-855.5ENInternational Journal of Hyperthermia, Vol 38, Iss 1, Pp 743-754 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	pulse magnetic hyperthermia temperature oscillations intermittent hyperthermia pulsatile heating thermoablation Medical technology R855-855.5
spellingShingle	pulse magnetic hyperthermia temperature oscillations intermittent hyperthermia pulsatile heating thermoablation Medical technology R855-855.5 Felista L. Tansi Wisdom O. Maduabuchi Melanie Hirsch Paul Southern Simon Hattersley Rainer Quaas Ulf Teichgräber Quentin A. Pankhurst Ingrid Hilger Deep-tissue localization of magnetic field hyperthermia using pulse sequencing
description	Objective Deep-tissue localization of thermal doses is a long-standing challenge in magnetic field hyperthermia (MFH), and remains a limitation of the clinical application of MFH to date. Here, we show that pulse sequencing of MFH leads to a more persistent inhibition of tumor growth and less systemic impact than continuous MFH, even when delivering the same thermal dose. Methods We used an in vivo orthotopic murine model of pancreatic PANC-1 cancer, which was designed with a view to the forthcoming ‘NoCanTher’ clinical study, and featured MFH alongside systemic chemotherapy (SyC: gemcitabine and nab-paclitaxel). In parallel, in silico thermal modelling was implemented. Results Tumor volumes 27 days after the start of MFH/SyC treatment were 53% (of the initial volume) in the pulse MFH group, compared to 136% in the continuous MFH group, and 337% in the non-treated controls. Systemically, pulse MFH led to ca. 50% less core-temperature increase in the mice for a given injected dose of magnetic heating agent, and inflicted lower levels of the stress marker, as seen in the blood-borne neutrophil-to-lymphocyte ratio (1.7, compared to 3.2 for continuous MFH + SyC, and 1.2 for controls). Conclusion Our data provided insights into the influence of pulse sequencing on the observed biological outcomes, and validated the nature of the improved thermal dose localization, alongside significant lowering of the overall energy expenditure entailed in the treatment.
format	article
author	Felista L. Tansi Wisdom O. Maduabuchi Melanie Hirsch Paul Southern Simon Hattersley Rainer Quaas Ulf Teichgräber Quentin A. Pankhurst Ingrid Hilger
author_facet	Felista L. Tansi Wisdom O. Maduabuchi Melanie Hirsch Paul Southern Simon Hattersley Rainer Quaas Ulf Teichgräber Quentin A. Pankhurst Ingrid Hilger
author_sort	Felista L. Tansi
title	Deep-tissue localization of magnetic field hyperthermia using pulse sequencing
title_short	Deep-tissue localization of magnetic field hyperthermia using pulse sequencing
title_full	Deep-tissue localization of magnetic field hyperthermia using pulse sequencing
title_fullStr	Deep-tissue localization of magnetic field hyperthermia using pulse sequencing
title_full_unstemmed	Deep-tissue localization of magnetic field hyperthermia using pulse sequencing
title_sort	deep-tissue localization of magnetic field hyperthermia using pulse sequencing
publisher	Taylor & Francis Group
publishDate	2021
url	https://doaj.org/article/360575b57d59400c930b4c1f5a733fdf
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Deep-tissue localization of magnetic field hyperthermia using pulse sequencing

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