Contrast sensitivity and higher-order aberrations in Keratoconus subjects

Abstract This study analyzes the relationship between contrast-sensitivity and higher-order aberrations (HOA) in mild and subclinical-keratoconus in subjects with good visual-acuity (VA). Keratoconus group (including subclinical-keratoconus) and controls underwent autokeratometry, corneal-tomography...

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Autores principales:	Einat Shneor, David P. Piñero, Ravid Doron
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/3608b3a2aa8146ee9d41398f9f0befe6
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spelling	oai:doaj.org-article:3608b3a2aa8146ee9d41398f9f0befe62021-12-02T17:44:54ZContrast sensitivity and higher-order aberrations in Keratoconus subjects10.1038/s41598-021-92396-52045-2322https://doaj.org/article/3608b3a2aa8146ee9d41398f9f0befe62021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-92396-5https://doaj.org/toc/2045-2322Abstract This study analyzes the relationship between contrast-sensitivity and higher-order aberrations (HOA) in mild and subclinical-keratoconus in subjects with good visual-acuity (VA). Keratoconus group (including subclinical-keratoconus) and controls underwent autokeratometry, corneal-tomography, autorefraction and HOA measurement. Contrast-sensitivity was tested using a psychophysical two-alternative forced-choice Gabor patches in three blocks (6, 9, 12 cycles/deg). Controls were compared to the keratoconus group and to a keratoconus subgroup with VA of 0.00 LogMar group ("keratoconus-0.00VA"). Spearman correlation tested association between HOA and contrast-sensitivity. Twenty-two keratoconus subjects (38 eyes: 28 keratoconus, 10 subclinical-keratoconus, 20 keratoconus-0.00VA) and 35 controls were included. There was a significant difference between control and keratoconus, and between control and keratoconus-0.00VA, for keratometry, cylinder, thinnest and central corneal thickness (p < 0.001). Controls showed lower HOA and higher contrast-sensitivity for all spatial-frequencies (p < 0.001). Most HOA were negatively correlated with contrast-sensitivity for all spatial-frequencies for keratoconus group and for 9 and 12 cycles/deg for keratoconus-0.00VA. Keratoconus subjects with good VA showed reduction in contrast-sensitivity and increased HOAs compared to controls. HOA and contrast-sensitivity are inversely correlated in subjects with mild keratoconus despite good VA. This suggests that the main mechanism underlying the decreased vision quality in keratoconus is the increase of HOA.Einat ShneorDavid P. PiñeroRavid DoronNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Einat Shneor David P. Piñero Ravid Doron Contrast sensitivity and higher-order aberrations in Keratoconus subjects
description	Abstract This study analyzes the relationship between contrast-sensitivity and higher-order aberrations (HOA) in mild and subclinical-keratoconus in subjects with good visual-acuity (VA). Keratoconus group (including subclinical-keratoconus) and controls underwent autokeratometry, corneal-tomography, autorefraction and HOA measurement. Contrast-sensitivity was tested using a psychophysical two-alternative forced-choice Gabor patches in three blocks (6, 9, 12 cycles/deg). Controls were compared to the keratoconus group and to a keratoconus subgroup with VA of 0.00 LogMar group ("keratoconus-0.00VA"). Spearman correlation tested association between HOA and contrast-sensitivity. Twenty-two keratoconus subjects (38 eyes: 28 keratoconus, 10 subclinical-keratoconus, 20 keratoconus-0.00VA) and 35 controls were included. There was a significant difference between control and keratoconus, and between control and keratoconus-0.00VA, for keratometry, cylinder, thinnest and central corneal thickness (p < 0.001). Controls showed lower HOA and higher contrast-sensitivity for all spatial-frequencies (p < 0.001). Most HOA were negatively correlated with contrast-sensitivity for all spatial-frequencies for keratoconus group and for 9 and 12 cycles/deg for keratoconus-0.00VA. Keratoconus subjects with good VA showed reduction in contrast-sensitivity and increased HOAs compared to controls. HOA and contrast-sensitivity are inversely correlated in subjects with mild keratoconus despite good VA. This suggests that the main mechanism underlying the decreased vision quality in keratoconus is the increase of HOA.
format	article
author	Einat Shneor David P. Piñero Ravid Doron
author_facet	Einat Shneor David P. Piñero Ravid Doron
author_sort	Einat Shneor
title	Contrast sensitivity and higher-order aberrations in Keratoconus subjects
title_short	Contrast sensitivity and higher-order aberrations in Keratoconus subjects
title_full	Contrast sensitivity and higher-order aberrations in Keratoconus subjects
title_fullStr	Contrast sensitivity and higher-order aberrations in Keratoconus subjects
title_full_unstemmed	Contrast sensitivity and higher-order aberrations in Keratoconus subjects
title_sort	contrast sensitivity and higher-order aberrations in keratoconus subjects
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/3608b3a2aa8146ee9d41398f9f0befe6
work_keys_str_mv	AT einatshneor contrastsensitivityandhigherorderaberrationsinkeratoconussubjects AT davidppinero contrastsensitivityandhigherorderaberrationsinkeratoconussubjects AT raviddoron contrastsensitivityandhigherorderaberrationsinkeratoconussubjects
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Contrast sensitivity and higher-order aberrations in Keratoconus subjects

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