Hypoxia inducible factor HIF-1 promotes myeloid-derived suppressor cells accumulation through ENTPD2/CD39L1 in hepatocellular carcinoma

Myeloid-derived suppressor cells (MDSCs) promote tumor immune escape. Here, the authors show that in hepatocellular carcinoma, hypoxia induces the expression of ENTPD2 on cancer cells leading to elevated extracellular 5′-AMP, which in turn promote the maintenance of MDSCs by preventing their differe...

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Autores principales:	David Kung-Chun Chiu, Aki Pui-Wah Tse, Iris Ming-Jing Xu, Jane Di Cui, Robin Kit-Ho Lai, Lynna Lan Li, Hui-Yu Koh, Felice Ho-Ching Tsang, Larry Lai Wei, Chun-Ming Wong, Irene Oi-Lin Ng, Carmen Chak-Lui Wong
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/360a1c2886224e2282f3c6518e7a0d34
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spelling	oai:doaj.org-article:360a1c2886224e2282f3c6518e7a0d342021-12-02T14:40:37ZHypoxia inducible factor HIF-1 promotes myeloid-derived suppressor cells accumulation through ENTPD2/CD39L1 in hepatocellular carcinoma10.1038/s41467-017-00530-72041-1723https://doaj.org/article/360a1c2886224e2282f3c6518e7a0d342017-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00530-7https://doaj.org/toc/2041-1723Myeloid-derived suppressor cells (MDSCs) promote tumor immune escape. Here, the authors show that in hepatocellular carcinoma, hypoxia induces the expression of ENTPD2 on cancer cells leading to elevated extracellular 5′-AMP, which in turn promote the maintenance of MDSCs by preventing their differentiation.David Kung-Chun ChiuAki Pui-Wah TseIris Ming-Jing XuJane Di CuiRobin Kit-Ho LaiLynna Lan LiHui-Yu KohFelice Ho-Ching TsangLarry Lai WeiChun-Ming WongIrene Oi-Lin NgCarmen Chak-Lui WongNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q David Kung-Chun Chiu Aki Pui-Wah Tse Iris Ming-Jing Xu Jane Di Cui Robin Kit-Ho Lai Lynna Lan Li Hui-Yu Koh Felice Ho-Ching Tsang Larry Lai Wei Chun-Ming Wong Irene Oi-Lin Ng Carmen Chak-Lui Wong Hypoxia inducible factor HIF-1 promotes myeloid-derived suppressor cells accumulation through ENTPD2/CD39L1 in hepatocellular carcinoma
description	Myeloid-derived suppressor cells (MDSCs) promote tumor immune escape. Here, the authors show that in hepatocellular carcinoma, hypoxia induces the expression of ENTPD2 on cancer cells leading to elevated extracellular 5′-AMP, which in turn promote the maintenance of MDSCs by preventing their differentiation.
format	article
author	David Kung-Chun Chiu Aki Pui-Wah Tse Iris Ming-Jing Xu Jane Di Cui Robin Kit-Ho Lai Lynna Lan Li Hui-Yu Koh Felice Ho-Ching Tsang Larry Lai Wei Chun-Ming Wong Irene Oi-Lin Ng Carmen Chak-Lui Wong
author_facet	David Kung-Chun Chiu Aki Pui-Wah Tse Iris Ming-Jing Xu Jane Di Cui Robin Kit-Ho Lai Lynna Lan Li Hui-Yu Koh Felice Ho-Ching Tsang Larry Lai Wei Chun-Ming Wong Irene Oi-Lin Ng Carmen Chak-Lui Wong
author_sort	David Kung-Chun Chiu
title	Hypoxia inducible factor HIF-1 promotes myeloid-derived suppressor cells accumulation through ENTPD2/CD39L1 in hepatocellular carcinoma
title_short	Hypoxia inducible factor HIF-1 promotes myeloid-derived suppressor cells accumulation through ENTPD2/CD39L1 in hepatocellular carcinoma
title_full	Hypoxia inducible factor HIF-1 promotes myeloid-derived suppressor cells accumulation through ENTPD2/CD39L1 in hepatocellular carcinoma
title_fullStr	Hypoxia inducible factor HIF-1 promotes myeloid-derived suppressor cells accumulation through ENTPD2/CD39L1 in hepatocellular carcinoma
title_full_unstemmed	Hypoxia inducible factor HIF-1 promotes myeloid-derived suppressor cells accumulation through ENTPD2/CD39L1 in hepatocellular carcinoma
title_sort	hypoxia inducible factor hif-1 promotes myeloid-derived suppressor cells accumulation through entpd2/cd39l1 in hepatocellular carcinoma
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/360a1c2886224e2282f3c6518e7a0d34
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Hypoxia inducible factor HIF-1 promotes myeloid-derived suppressor cells accumulation through ENTPD2/CD39L1 in hepatocellular carcinoma

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