Assessment of drug-drug interactions in hypertensive patients at a superspeciality hospital

Objective: The objective of the study was to assess the incidence and pattern of drug-drug interactions (DDIs) in hypertensive patients by using Micromedex and Medscape databases. Materials and Methods: A prospective observational study was carried out in a superspeciality hospital setting...

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Autores principales:	Divya Sivva, Uday Venkat Mateti, Venu Madhav Neerati, Nimbagiri Swamy Thiruthopu, Srinivas Martha
Formato:	article
Lenguaje:	EN
Publicado:	Thieme Medical and Scientific Publishers Pvt. Ltd. 2015
Materias:	drug-drug interactions hypertension incidence micromedex medscape Medicine R
Acceso en línea:	https://doaj.org/article/360f68c8f3a549afaf3c0e5714c7c2be
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spelling	oai:doaj.org-article:360f68c8f3a549afaf3c0e5714c7c2be2021-12-02T17:59:03ZAssessment of drug-drug interactions in hypertensive patients at a superspeciality hospital2231-07702249-446410.4103/2231-0770.154194https://doaj.org/article/360f68c8f3a549afaf3c0e5714c7c2be2015-04-01T00:00:00Zhttp://www.thieme-connect.de/DOI/DOI?10.4103/2231-0770.154194https://doaj.org/toc/2231-0770https://doaj.org/toc/2249-4464Objective: The objective of the study was to assess the incidence and pattern of drug-drug interactions (DDIs) in hypertensive patients by using Micromedex and Medscape databases. Materials and Methods: A prospective observational study was carried out in a superspeciality hospital setting in South India for period of 9 months. Hypertensive patients who admitted into the hospital with the age more than 18 years, received more than 3 drugs per prescription and length of hospital stay for more than 24 hours were included in the study. An appropriate data was collected and assessed for DDIs with the help of Micromedex and Medscape databases. Results: A total of 227 patients were enrolled during the study period. Among the 227 patients, 48 of them developed 53 clinically significant DDIs. Out of 48 patients, most of them were in the age-group of 50-60 years [18 (37.49%)]. The percentage of DDIs were higher in males [30 (62.5%)] compared to females [18 (37.5%)]. The most common drugs responsible for DDIs in the present study were Insulin [18 (33.96%)] followed by Metoprolol [10 (18.86%)], Torsemide [8 (15.09%)], and Hydrochlorothiazide [8 (15.09%)]. The most commonly interacting pairs were Ciprofloxacin-Insulin [6 (11.32%)], followed by Metoprolol-Insulin [4 (7.54%)] and Atenolol-Insulin [4 (7.54%)]. The most common consequences of interacting pairs were reduced serum potassium levels and hyperglycemia. Conclusion: The overall incidence rate of DDIs was found to be 21.14% and the increasing number of co-morbidities ( P ≤ 0.003) and polypharmacy ( P ≤ 0.002) were the risk factor for the development of significant number of DDIs.Divya SivvaUday Venkat MatetiVenu Madhav NeeratiNimbagiri Swamy ThiruthopuSrinivas MarthaThieme Medical and Scientific Publishers Pvt. Ltd.articledrug-drug interactionshypertensionincidencemicromedexmedscapeMedicineRENAvicenna Journal of Medicine, Vol 05, Iss 02, Pp 29-35 (2015)
institution	DOAJ
collection	DOAJ
language	EN
topic	drug-drug interactions hypertension incidence micromedex medscape Medicine R
spellingShingle	drug-drug interactions hypertension incidence micromedex medscape Medicine R Divya Sivva Uday Venkat Mateti Venu Madhav Neerati Nimbagiri Swamy Thiruthopu Srinivas Martha Assessment of drug-drug interactions in hypertensive patients at a superspeciality hospital
description	Objective: The objective of the study was to assess the incidence and pattern of drug-drug interactions (DDIs) in hypertensive patients by using Micromedex and Medscape databases. Materials and Methods: A prospective observational study was carried out in a superspeciality hospital setting in South India for period of 9 months. Hypertensive patients who admitted into the hospital with the age more than 18 years, received more than 3 drugs per prescription and length of hospital stay for more than 24 hours were included in the study. An appropriate data was collected and assessed for DDIs with the help of Micromedex and Medscape databases. Results: A total of 227 patients were enrolled during the study period. Among the 227 patients, 48 of them developed 53 clinically significant DDIs. Out of 48 patients, most of them were in the age-group of 50-60 years [18 (37.49%)]. The percentage of DDIs were higher in males [30 (62.5%)] compared to females [18 (37.5%)]. The most common drugs responsible for DDIs in the present study were Insulin [18 (33.96%)] followed by Metoprolol [10 (18.86%)], Torsemide [8 (15.09%)], and Hydrochlorothiazide [8 (15.09%)]. The most commonly interacting pairs were Ciprofloxacin-Insulin [6 (11.32%)], followed by Metoprolol-Insulin [4 (7.54%)] and Atenolol-Insulin [4 (7.54%)]. The most common consequences of interacting pairs were reduced serum potassium levels and hyperglycemia. Conclusion: The overall incidence rate of DDIs was found to be 21.14% and the increasing number of co-morbidities ( P ≤ 0.003) and polypharmacy ( P ≤ 0.002) were the risk factor for the development of significant number of DDIs.
format	article
author	Divya Sivva Uday Venkat Mateti Venu Madhav Neerati Nimbagiri Swamy Thiruthopu Srinivas Martha
author_facet	Divya Sivva Uday Venkat Mateti Venu Madhav Neerati Nimbagiri Swamy Thiruthopu Srinivas Martha
author_sort	Divya Sivva
title	Assessment of drug-drug interactions in hypertensive patients at a superspeciality hospital
title_short	Assessment of drug-drug interactions in hypertensive patients at a superspeciality hospital
title_full	Assessment of drug-drug interactions in hypertensive patients at a superspeciality hospital
title_fullStr	Assessment of drug-drug interactions in hypertensive patients at a superspeciality hospital
title_full_unstemmed	Assessment of drug-drug interactions in hypertensive patients at a superspeciality hospital
title_sort	assessment of drug-drug interactions in hypertensive patients at a superspeciality hospital
publisher	Thieme Medical and Scientific Publishers Pvt. Ltd.
publishDate	2015
url	https://doaj.org/article/360f68c8f3a549afaf3c0e5714c7c2be
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Assessment of drug-drug interactions in hypertensive patients at a superspeciality hospital

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