VGLL4 targets a TCF4–TEAD4 complex to coregulate Wnt and Hippo signalling in colorectal cancer

The Wnt/β-catenin and YAP signaling pathways have fundamental roles in cancer. Here, the authors show that VGLL4, a known YAP antagonist, also negatively regulates Wnt/β-catenin signaling by targeting TEAD-DNA-TCF4 complex, thereby inhibiting colorectal cancer growth.

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Autores principales:	Shi Jiao, Chuanchuan Li, Qian Hao, Haofei Miao, Lei Zhang, Lin Li, Zhaocai Zhou
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/36129b9f92564d00ba6b568aae6c77ee
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spelling	oai:doaj.org-article:36129b9f92564d00ba6b568aae6c77ee2021-12-02T15:38:52ZVGLL4 targets a TCF4–TEAD4 complex to coregulate Wnt and Hippo signalling in colorectal cancer10.1038/ncomms140582041-1723https://doaj.org/article/36129b9f92564d00ba6b568aae6c77ee2017-01-01T00:00:00Zhttps://doi.org/10.1038/ncomms14058https://doaj.org/toc/2041-1723The Wnt/β-catenin and YAP signaling pathways have fundamental roles in cancer. Here, the authors show that VGLL4, a known YAP antagonist, also negatively regulates Wnt/β-catenin signaling by targeting TEAD-DNA-TCF4 complex, thereby inhibiting colorectal cancer growth.Shi JiaoChuanchuan LiQian HaoHaofei MiaoLei ZhangLin LiZhaocai ZhouNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Shi Jiao Chuanchuan Li Qian Hao Haofei Miao Lei Zhang Lin Li Zhaocai Zhou VGLL4 targets a TCF4–TEAD4 complex to coregulate Wnt and Hippo signalling in colorectal cancer
description	The Wnt/β-catenin and YAP signaling pathways have fundamental roles in cancer. Here, the authors show that VGLL4, a known YAP antagonist, also negatively regulates Wnt/β-catenin signaling by targeting TEAD-DNA-TCF4 complex, thereby inhibiting colorectal cancer growth.
format	article
author	Shi Jiao Chuanchuan Li Qian Hao Haofei Miao Lei Zhang Lin Li Zhaocai Zhou
author_facet	Shi Jiao Chuanchuan Li Qian Hao Haofei Miao Lei Zhang Lin Li Zhaocai Zhou
author_sort	Shi Jiao
title	VGLL4 targets a TCF4–TEAD4 complex to coregulate Wnt and Hippo signalling in colorectal cancer
title_short	VGLL4 targets a TCF4–TEAD4 complex to coregulate Wnt and Hippo signalling in colorectal cancer
title_full	VGLL4 targets a TCF4–TEAD4 complex to coregulate Wnt and Hippo signalling in colorectal cancer
title_fullStr	VGLL4 targets a TCF4–TEAD4 complex to coregulate Wnt and Hippo signalling in colorectal cancer
title_full_unstemmed	VGLL4 targets a TCF4–TEAD4 complex to coregulate Wnt and Hippo signalling in colorectal cancer
title_sort	vgll4 targets a tcf4–tead4 complex to coregulate wnt and hippo signalling in colorectal cancer
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/36129b9f92564d00ba6b568aae6c77ee
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VGLL4 targets a TCF4–TEAD4 complex to coregulate Wnt and Hippo signalling in colorectal cancer

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