Safety and Efficacy of a New Smartphone-controlled Vibrating Capsule on Defecation in Beagles

Abstract Constipation, mainly manifesting as abdominal discomfort and painful defecation, is considered as a chronic disorder. Due to a lack of effective therapy, it imposes a significant economic burden and greatly impacts patients’ quality of life which prompt searches for new, original approaches...

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Autores principales:	Jin Yu, Yang-Yang Qian, Chao-Hui He, Shu-Guang Zhu, An-Jing Zhao, Qian-Qian Zhu, Cheng-Wei Shao, Tie-Gong Wang, Yang Wang, Gui-Ling Ding, Zhuan Liao, Zhao-Shen Li
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/3614db197c1c483ba79766432910ef59
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spelling	oai:doaj.org-article:3614db197c1c483ba79766432910ef592021-12-02T11:53:04ZSafety and Efficacy of a New Smartphone-controlled Vibrating Capsule on Defecation in Beagles10.1038/s41598-017-02844-42045-2322https://doaj.org/article/3614db197c1c483ba79766432910ef592017-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-02844-4https://doaj.org/toc/2045-2322Abstract Constipation, mainly manifesting as abdominal discomfort and painful defecation, is considered as a chronic disorder. Due to a lack of effective therapy, it imposes a significant economic burden and greatly impacts patients’ quality of life which prompt searches for new, original approaches. Based on the research of vibrating capsule (VC) carried out by Ron et al., we investigated the safety and efficacy of an innovative, multi-mode VC in terms of its effect on defecation in animal studies. The parameters associated with different operation modes of VCs can be detected and adjusted by smartphone controlled external configuration device (ECD). The results of blood tests, physiological parameters, CT scan and pathological examination showed no significant abnormality, which undoubtedly confirmed the safety of VCs. For efficacy studies, defecation frequency of beagles increased after administration of these capsules without influence on stool characters. Meanwhile, the mean time of capsule evacuation tended to be reduced while showing no significant difference between different modes. In summary, this study elucidates the safety and effectiveness of VC in prompting the passage of gastrointestinal walls thus greatly increasing the defecation frequency. This study innovatively displays the promising application of VC in the treatment of constipation.Jin YuYang-Yang QianChao-Hui HeShu-Guang ZhuAn-Jing ZhaoQian-Qian ZhuCheng-Wei ShaoTie-Gong WangYang WangGui-Ling DingZhuan LiaoZhao-Shen LiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-7 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jin Yu Yang-Yang Qian Chao-Hui He Shu-Guang Zhu An-Jing Zhao Qian-Qian Zhu Cheng-Wei Shao Tie-Gong Wang Yang Wang Gui-Ling Ding Zhuan Liao Zhao-Shen Li Safety and Efficacy of a New Smartphone-controlled Vibrating Capsule on Defecation in Beagles
description	Abstract Constipation, mainly manifesting as abdominal discomfort and painful defecation, is considered as a chronic disorder. Due to a lack of effective therapy, it imposes a significant economic burden and greatly impacts patients’ quality of life which prompt searches for new, original approaches. Based on the research of vibrating capsule (VC) carried out by Ron et al., we investigated the safety and efficacy of an innovative, multi-mode VC in terms of its effect on defecation in animal studies. The parameters associated with different operation modes of VCs can be detected and adjusted by smartphone controlled external configuration device (ECD). The results of blood tests, physiological parameters, CT scan and pathological examination showed no significant abnormality, which undoubtedly confirmed the safety of VCs. For efficacy studies, defecation frequency of beagles increased after administration of these capsules without influence on stool characters. Meanwhile, the mean time of capsule evacuation tended to be reduced while showing no significant difference between different modes. In summary, this study elucidates the safety and effectiveness of VC in prompting the passage of gastrointestinal walls thus greatly increasing the defecation frequency. This study innovatively displays the promising application of VC in the treatment of constipation.
format	article
author	Jin Yu Yang-Yang Qian Chao-Hui He Shu-Guang Zhu An-Jing Zhao Qian-Qian Zhu Cheng-Wei Shao Tie-Gong Wang Yang Wang Gui-Ling Ding Zhuan Liao Zhao-Shen Li
author_facet	Jin Yu Yang-Yang Qian Chao-Hui He Shu-Guang Zhu An-Jing Zhao Qian-Qian Zhu Cheng-Wei Shao Tie-Gong Wang Yang Wang Gui-Ling Ding Zhuan Liao Zhao-Shen Li
author_sort	Jin Yu
title	Safety and Efficacy of a New Smartphone-controlled Vibrating Capsule on Defecation in Beagles
title_short	Safety and Efficacy of a New Smartphone-controlled Vibrating Capsule on Defecation in Beagles
title_full	Safety and Efficacy of a New Smartphone-controlled Vibrating Capsule on Defecation in Beagles
title_fullStr	Safety and Efficacy of a New Smartphone-controlled Vibrating Capsule on Defecation in Beagles
title_full_unstemmed	Safety and Efficacy of a New Smartphone-controlled Vibrating Capsule on Defecation in Beagles
title_sort	safety and efficacy of a new smartphone-controlled vibrating capsule on defecation in beagles
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/3614db197c1c483ba79766432910ef59
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Safety and Efficacy of a New Smartphone-controlled Vibrating Capsule on Defecation in Beagles

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