PTEN loss promotes oncogenic function of STMN1 via PI3K/AKT pathway in lung cancer

Abstract Among all cancer types, lung cancer has already become the leading cause of cancer-related death around the world. The molecular mechanism understanding this development is still needed to be improved to treat lung cancer. Stathmin (STMN1) was initially identified as a cytoplasmic protein p...

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Autores principales:	Guangsu Xun, Wei Hu, Bing Li
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/361630ecff1c40118e1b8900f865049a
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spelling	oai:doaj.org-article:361630ecff1c40118e1b8900f865049a2021-12-02T16:08:08ZPTEN loss promotes oncogenic function of STMN1 via PI3K/AKT pathway in lung cancer10.1038/s41598-021-93815-32045-2322https://doaj.org/article/361630ecff1c40118e1b8900f865049a2021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-93815-3https://doaj.org/toc/2045-2322Abstract Among all cancer types, lung cancer has already become the leading cause of cancer-related death around the world. The molecular mechanism understanding this development is still needed to be improved to treat lung cancer. Stathmin (STMN1) was initially identified as a cytoplasmic protein phosphorylated responding to cell signal and controlled cell physiological processes. The dysregulation of STMN1 is found in various kinds of tumors. However, the molecular mechanism of STMN1 regulating lung cancer is still unclear. Here, we found that STMN1 was overexpressed in lung cancer tissues and associated with worse survival rates of lung cancer patients. Inhibition of STMN1 suppressed lung cancer cell growth, migration and invasion, and promoted drug sensitivity. Moreover, PTEN loss promoted STMN1 expression via PI3K/AKT pathway. PTEN loss ameliorated the inhibition of cell growth, migration and invasion, and drug sensitivity induced by STMN1 knockdown in lung cancer. The high expression of STMN1 was negatively correlated with the low expression of PTEN in lung cancer specimens. Overall, our work demonstrated that PTEN regulated the oncogenic function of STMN1 in lung cancer.Guangsu XunWei HuBing LiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Guangsu Xun Wei Hu Bing Li PTEN loss promotes oncogenic function of STMN1 via PI3K/AKT pathway in lung cancer
description	Abstract Among all cancer types, lung cancer has already become the leading cause of cancer-related death around the world. The molecular mechanism understanding this development is still needed to be improved to treat lung cancer. Stathmin (STMN1) was initially identified as a cytoplasmic protein phosphorylated responding to cell signal and controlled cell physiological processes. The dysregulation of STMN1 is found in various kinds of tumors. However, the molecular mechanism of STMN1 regulating lung cancer is still unclear. Here, we found that STMN1 was overexpressed in lung cancer tissues and associated with worse survival rates of lung cancer patients. Inhibition of STMN1 suppressed lung cancer cell growth, migration and invasion, and promoted drug sensitivity. Moreover, PTEN loss promoted STMN1 expression via PI3K/AKT pathway. PTEN loss ameliorated the inhibition of cell growth, migration and invasion, and drug sensitivity induced by STMN1 knockdown in lung cancer. The high expression of STMN1 was negatively correlated with the low expression of PTEN in lung cancer specimens. Overall, our work demonstrated that PTEN regulated the oncogenic function of STMN1 in lung cancer.
format	article
author	Guangsu Xun Wei Hu Bing Li
author_facet	Guangsu Xun Wei Hu Bing Li
author_sort	Guangsu Xun
title	PTEN loss promotes oncogenic function of STMN1 via PI3K/AKT pathway in lung cancer
title_short	PTEN loss promotes oncogenic function of STMN1 via PI3K/AKT pathway in lung cancer
title_full	PTEN loss promotes oncogenic function of STMN1 via PI3K/AKT pathway in lung cancer
title_fullStr	PTEN loss promotes oncogenic function of STMN1 via PI3K/AKT pathway in lung cancer
title_full_unstemmed	PTEN loss promotes oncogenic function of STMN1 via PI3K/AKT pathway in lung cancer
title_sort	pten loss promotes oncogenic function of stmn1 via pi3k/akt pathway in lung cancer
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/361630ecff1c40118e1b8900f865049a
work_keys_str_mv	AT guangsuxun ptenlosspromotesoncogenicfunctionofstmn1viapi3kaktpathwayinlungcancer AT weihu ptenlosspromotesoncogenicfunctionofstmn1viapi3kaktpathwayinlungcancer AT bingli ptenlosspromotesoncogenicfunctionofstmn1viapi3kaktpathwayinlungcancer
_version_	1718384586732339200

PTEN loss promotes oncogenic function of STMN1 via PI3K/AKT pathway in lung cancer

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