Shisa6 traps AMPA receptors at postsynaptic sites and prevents their desensitization during synaptic activity
Auxiliary AMPA receptor subunits can affect gating and surface mobility. Here the authors show that Shisa6 traps AMPA receptors at postsynaptic sites via PSD-95, and keeps them in an activated state in the presence of glutamate, preventing full desensitization and consequently synaptic depression.
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Nature Portfolio
2016
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| Acceso en línea: | https://doaj.org/article/3618aa11f0194d7bb076e4d881df1108 |
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oai:doaj.org-article:3618aa11f0194d7bb076e4d881df11082021-12-02T17:33:09ZShisa6 traps AMPA receptors at postsynaptic sites and prevents their desensitization during synaptic activity10.1038/ncomms106822041-1723https://doaj.org/article/3618aa11f0194d7bb076e4d881df11082016-03-01T00:00:00Zhttps://doi.org/10.1038/ncomms10682https://doaj.org/toc/2041-1723Auxiliary AMPA receptor subunits can affect gating and surface mobility. Here the authors show that Shisa6 traps AMPA receptors at postsynaptic sites via PSD-95, and keeps them in an activated state in the presence of glutamate, preventing full desensitization and consequently synaptic depression.Remco V. KlaassenJasper StroederFrançoise CoussenAnne-Sophie HafnerJennifer D. PetersenCedric RenancioLeanne J. M. SchmitzElisabeth NormandJohannes C. LodderDiana C. RotaruPriyanka Rao-RuizSabine SpijkerHuibert D. MansvelderDaniel ChoquetAugust B. SmitNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-12 (2016) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Remco V. Klaassen Jasper Stroeder Françoise Coussen Anne-Sophie Hafner Jennifer D. Petersen Cedric Renancio Leanne J. M. Schmitz Elisabeth Normand Johannes C. Lodder Diana C. Rotaru Priyanka Rao-Ruiz Sabine Spijker Huibert D. Mansvelder Daniel Choquet August B. Smit Shisa6 traps AMPA receptors at postsynaptic sites and prevents their desensitization during synaptic activity |
| description |
Auxiliary AMPA receptor subunits can affect gating and surface mobility. Here the authors show that Shisa6 traps AMPA receptors at postsynaptic sites via PSD-95, and keeps them in an activated state in the presence of glutamate, preventing full desensitization and consequently synaptic depression. |
| format |
article |
| author |
Remco V. Klaassen Jasper Stroeder Françoise Coussen Anne-Sophie Hafner Jennifer D. Petersen Cedric Renancio Leanne J. M. Schmitz Elisabeth Normand Johannes C. Lodder Diana C. Rotaru Priyanka Rao-Ruiz Sabine Spijker Huibert D. Mansvelder Daniel Choquet August B. Smit |
| author_facet |
Remco V. Klaassen Jasper Stroeder Françoise Coussen Anne-Sophie Hafner Jennifer D. Petersen Cedric Renancio Leanne J. M. Schmitz Elisabeth Normand Johannes C. Lodder Diana C. Rotaru Priyanka Rao-Ruiz Sabine Spijker Huibert D. Mansvelder Daniel Choquet August B. Smit |
| author_sort |
Remco V. Klaassen |
| title |
Shisa6 traps AMPA receptors at postsynaptic sites and prevents their desensitization during synaptic activity |
| title_short |
Shisa6 traps AMPA receptors at postsynaptic sites and prevents their desensitization during synaptic activity |
| title_full |
Shisa6 traps AMPA receptors at postsynaptic sites and prevents their desensitization during synaptic activity |
| title_fullStr |
Shisa6 traps AMPA receptors at postsynaptic sites and prevents their desensitization during synaptic activity |
| title_full_unstemmed |
Shisa6 traps AMPA receptors at postsynaptic sites and prevents their desensitization during synaptic activity |
| title_sort |
shisa6 traps ampa receptors at postsynaptic sites and prevents their desensitization during synaptic activity |
| publisher |
Nature Portfolio |
| publishDate |
2016 |
| url |
https://doaj.org/article/3618aa11f0194d7bb076e4d881df1108 |
| work_keys_str_mv |
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| _version_ |
1718380055593222144 |