Shisa6 traps AMPA receptors at postsynaptic sites and prevents their desensitization during synaptic activity

Shisa6 traps AMPA receptors at postsynaptic sites and prevents their desensitization during synaptic activity

Auxiliary AMPA receptor subunits can affect gating and surface mobility. Here the authors show that Shisa6 traps AMPA receptors at postsynaptic sites via PSD-95, and keeps them in an activated state in the presence of glutamate, preventing full desensitization and consequently synaptic depression.

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Auteurs principaux: Remco V. Klaassen, Jasper Stroeder, Françoise Coussen, Anne-Sophie Hafner, Jennifer D. Petersen, Cedric Renancio, Leanne J. M. Schmitz, Elisabeth Normand, Johannes C. Lodder, Diana C. Rotaru, Priyanka Rao-Ruiz, Sabine Spijker, Huibert D. Mansvelder, Daniel Choquet, August B. Smit
Format: article
Langue:EN
Publié: Nature Portfolio 2016
Sujets:
Science
Q
Accès en ligne:https://doaj.org/article/3618aa11f0194d7bb076e4d881df1108
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Internet

https://doaj.org/article/3618aa11f0194d7bb076e4d881df1108

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