B2M overexpression correlates with malignancy and immune signatures in human gliomas

Abstract Because of the limited treatment strategy of gliomas, the key of diagnosis and treatment is finding new molecular biomarkers. Here, we explored the potential of β2-microglobulin (B2M) to serve as a hopeful candidate for immunotherapy or diagnostic biomarker in gliomas. The genomic profiles,...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Hao Zhang, Biqi Cui, Yulai Zhou, Xinxing Wang, Wantao Wu, Zeyu Wang, Ziyu Dai, Quan Cheng, Kui Yang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/361963f8f55e4fc9b19b5bf3100bba81
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:361963f8f55e4fc9b19b5bf3100bba81
record_format	dspace
spelling	oai:doaj.org-article:361963f8f55e4fc9b19b5bf3100bba812021-12-02T13:34:46ZB2M overexpression correlates with malignancy and immune signatures in human gliomas10.1038/s41598-021-84465-62045-2322https://doaj.org/article/361963f8f55e4fc9b19b5bf3100bba812021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-84465-6https://doaj.org/toc/2045-2322Abstract Because of the limited treatment strategy of gliomas, the key of diagnosis and treatment is finding new molecular biomarkers. Here, we explored the potential of β2-microglobulin (B2M) to serve as a hopeful candidate for immunotherapy or diagnostic biomarker in gliomas. The genomic profiles, clinical characteristics, and immune signatures were analyzed based on TCGA and CGGA databases. We carried out the whole statistical analyses using R project. High B2M expression correlated with worse prognosis. Somatic mutations of gliomas with high B2M expression are associated with PTEN deletion and EGFR amplification. Isocitrate dehydrogenase (IDH) mutations accounted for 82% in gliomas with low B2M expression. In addition, B2M positively correlated with ESTIMATE scores, interacted with infiltrating immune and stromal cell types. B2M also suppressed anti-tumor immunity through immune related processes. Meanwhile, B2M was associated with immune checkpoint molecules and inflammatory activities. Finally, functional annotation of the identified B2M related genes verified that B2M was a potential candidate for immunotherapy. We confirmed that B2M played a critical role in tumor progression, patient prognosis and immunotherapy of gliomas.Hao ZhangBiqi CuiYulai ZhouXinxing WangWantao WuZeyu WangZiyu DaiQuan ChengKui YangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hao Zhang Biqi Cui Yulai Zhou Xinxing Wang Wantao Wu Zeyu Wang Ziyu Dai Quan Cheng Kui Yang B2M overexpression correlates with malignancy and immune signatures in human gliomas
description	Abstract Because of the limited treatment strategy of gliomas, the key of diagnosis and treatment is finding new molecular biomarkers. Here, we explored the potential of β2-microglobulin (B2M) to serve as a hopeful candidate for immunotherapy or diagnostic biomarker in gliomas. The genomic profiles, clinical characteristics, and immune signatures were analyzed based on TCGA and CGGA databases. We carried out the whole statistical analyses using R project. High B2M expression correlated with worse prognosis. Somatic mutations of gliomas with high B2M expression are associated with PTEN deletion and EGFR amplification. Isocitrate dehydrogenase (IDH) mutations accounted for 82% in gliomas with low B2M expression. In addition, B2M positively correlated with ESTIMATE scores, interacted with infiltrating immune and stromal cell types. B2M also suppressed anti-tumor immunity through immune related processes. Meanwhile, B2M was associated with immune checkpoint molecules and inflammatory activities. Finally, functional annotation of the identified B2M related genes verified that B2M was a potential candidate for immunotherapy. We confirmed that B2M played a critical role in tumor progression, patient prognosis and immunotherapy of gliomas.
format	article
author	Hao Zhang Biqi Cui Yulai Zhou Xinxing Wang Wantao Wu Zeyu Wang Ziyu Dai Quan Cheng Kui Yang
author_facet	Hao Zhang Biqi Cui Yulai Zhou Xinxing Wang Wantao Wu Zeyu Wang Ziyu Dai Quan Cheng Kui Yang
author_sort	Hao Zhang
title	B2M overexpression correlates with malignancy and immune signatures in human gliomas
title_short	B2M overexpression correlates with malignancy and immune signatures in human gliomas
title_full	B2M overexpression correlates with malignancy and immune signatures in human gliomas
title_fullStr	B2M overexpression correlates with malignancy and immune signatures in human gliomas
title_full_unstemmed	B2M overexpression correlates with malignancy and immune signatures in human gliomas
title_sort	b2m overexpression correlates with malignancy and immune signatures in human gliomas
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/361963f8f55e4fc9b19b5bf3100bba81
work_keys_str_mv	AT haozhang b2moverexpressioncorrelateswithmalignancyandimmunesignaturesinhumangliomas AT biqicui b2moverexpressioncorrelateswithmalignancyandimmunesignaturesinhumangliomas AT yulaizhou b2moverexpressioncorrelateswithmalignancyandimmunesignaturesinhumangliomas AT xinxingwang b2moverexpressioncorrelateswithmalignancyandimmunesignaturesinhumangliomas AT wantaowu b2moverexpressioncorrelateswithmalignancyandimmunesignaturesinhumangliomas AT zeyuwang b2moverexpressioncorrelateswithmalignancyandimmunesignaturesinhumangliomas AT ziyudai b2moverexpressioncorrelateswithmalignancyandimmunesignaturesinhumangliomas AT quancheng b2moverexpressioncorrelateswithmalignancyandimmunesignaturesinhumangliomas AT kuiyang b2moverexpressioncorrelateswithmalignancyandimmunesignaturesinhumangliomas
_version_	1718392727145545728

B2M overexpression correlates with malignancy and immune signatures in human gliomas

Ejemplares similares