Endoscopic sinus surgery and aspirin desensitization improve otologic-specific SNOT-22 scores

Objective: There are few studies evaluating the impact of Aspirin-exacerbated respiratory disease (AERD) treatment on otologic symptoms. The aim of this study is to evaluate the effects of endoscopic sinus surgery (ESS) and aspirin desensitization (AD) on otologic symptoms in subjects with AERD. Met...

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Autores principales:	James G. Naples, Andrew Corr, Siddhant Tripathi, Morgan Berman, Jason A. Brant, Michael J. Ruckenstein, John Bosso
Formato:	article
Lenguaje:	EN
Publicado:	KeAi Communications Co., Ltd. 2020
Materias:	Aspirin exacerbated respiratory disease Otologic symptoms SNOT-22 Otorhinolaryngology RF1-547 Surgery RD1-811
Acceso en línea:	https://doaj.org/article/361d893421ce4eee888e30d73f73109c
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spelling	oai:doaj.org-article:361d893421ce4eee888e30d73f73109c2021-12-02T18:12:37ZEndoscopic sinus surgery and aspirin desensitization improve otologic-specific SNOT-22 scores2095-881110.1016/j.wjorl.2020.07.006https://doaj.org/article/361d893421ce4eee888e30d73f73109c2020-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2095881120301359https://doaj.org/toc/2095-8811Objective: There are few studies evaluating the impact of Aspirin-exacerbated respiratory disease (AERD) treatment on otologic symptoms. The aim of this study is to evaluate the effects of endoscopic sinus surgery (ESS) and aspirin desensitization (AD) on otologic symptoms in subjects with AERD. Methods: Retrospective chart review of adult patients diagnosed with AERD at our tertiary Care Academic Medical Center - Otorhinolaryngology Department. Charts of adult patients diagnosed with AERD who underwent ESS and ASA desensitization at our institution's AERD Center from 2016 to 2019 were reviewed. Sino-Nasal Outcomes Test 22-item survey (SNOT-22) scores were evaluated for patients at various time points including: pre-surgery, post-surgery/pre-aspirin desensitization, and various times post-desensitization up to >12 months. Within the SNOT-22, otologic-specific subdomain scores were evaluated at similar time points. Patients on immunomodulatory medications other than corticosteroids were excluded from analysis. Results: SNOT-22 scores were analyzed for 121 patients. There was a significant improvement in overall SNOT scores from pre-surgery (44.62) to post surgery/pre-desensitization (23.34) (P < 0.0005). Similarly, SNOT-22 otologic-specific scores also improved after surgery prior to desensitization (3.19–2.04) (P = 0.005). Following AD, the improvement in the overall SNOT-22 continued to improve for up to 12 months (P < 0.005). While the otologic-specific SNOT-22 scores remained stable after surgery and ASA desensitization. Conclusion: ESS and AD reduce otologic-specific SNOT-22 scores and parallel trends in overall SNOT-22 scores. The effect of treatment is durable over the course of 12 months. Future work should aim to correlate otologic SNOT-22 scores with objective otologic data.James G. NaplesAndrew CorrSiddhant TripathiMorgan BermanJason A. BrantMichael J. RuckensteinJohn BossoKeAi Communications Co., Ltd.articleAspirin exacerbated respiratory diseaseOtologic symptomsSNOT-22OtorhinolaryngologyRF1-547SurgeryRD1-811ENWorld Journal of Otorhinolaryngology-Head and Neck Surgery, Vol 6, Iss 4, Pp 248-254 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Aspirin exacerbated respiratory disease Otologic symptoms SNOT-22 Otorhinolaryngology RF1-547 Surgery RD1-811
spellingShingle	Aspirin exacerbated respiratory disease Otologic symptoms SNOT-22 Otorhinolaryngology RF1-547 Surgery RD1-811 James G. Naples Andrew Corr Siddhant Tripathi Morgan Berman Jason A. Brant Michael J. Ruckenstein John Bosso Endoscopic sinus surgery and aspirin desensitization improve otologic-specific SNOT-22 scores
description	Objective: There are few studies evaluating the impact of Aspirin-exacerbated respiratory disease (AERD) treatment on otologic symptoms. The aim of this study is to evaluate the effects of endoscopic sinus surgery (ESS) and aspirin desensitization (AD) on otologic symptoms in subjects with AERD. Methods: Retrospective chart review of adult patients diagnosed with AERD at our tertiary Care Academic Medical Center - Otorhinolaryngology Department. Charts of adult patients diagnosed with AERD who underwent ESS and ASA desensitization at our institution's AERD Center from 2016 to 2019 were reviewed. Sino-Nasal Outcomes Test 22-item survey (SNOT-22) scores were evaluated for patients at various time points including: pre-surgery, post-surgery/pre-aspirin desensitization, and various times post-desensitization up to >12 months. Within the SNOT-22, otologic-specific subdomain scores were evaluated at similar time points. Patients on immunomodulatory medications other than corticosteroids were excluded from analysis. Results: SNOT-22 scores were analyzed for 121 patients. There was a significant improvement in overall SNOT scores from pre-surgery (44.62) to post surgery/pre-desensitization (23.34) (P < 0.0005). Similarly, SNOT-22 otologic-specific scores also improved after surgery prior to desensitization (3.19–2.04) (P = 0.005). Following AD, the improvement in the overall SNOT-22 continued to improve for up to 12 months (P < 0.005). While the otologic-specific SNOT-22 scores remained stable after surgery and ASA desensitization. Conclusion: ESS and AD reduce otologic-specific SNOT-22 scores and parallel trends in overall SNOT-22 scores. The effect of treatment is durable over the course of 12 months. Future work should aim to correlate otologic SNOT-22 scores with objective otologic data.
format	article
author	James G. Naples Andrew Corr Siddhant Tripathi Morgan Berman Jason A. Brant Michael J. Ruckenstein John Bosso
author_facet	James G. Naples Andrew Corr Siddhant Tripathi Morgan Berman Jason A. Brant Michael J. Ruckenstein John Bosso
author_sort	James G. Naples
title	Endoscopic sinus surgery and aspirin desensitization improve otologic-specific SNOT-22 scores
title_short	Endoscopic sinus surgery and aspirin desensitization improve otologic-specific SNOT-22 scores
title_full	Endoscopic sinus surgery and aspirin desensitization improve otologic-specific SNOT-22 scores
title_fullStr	Endoscopic sinus surgery and aspirin desensitization improve otologic-specific SNOT-22 scores
title_full_unstemmed	Endoscopic sinus surgery and aspirin desensitization improve otologic-specific SNOT-22 scores
title_sort	endoscopic sinus surgery and aspirin desensitization improve otologic-specific snot-22 scores
publisher	KeAi Communications Co., Ltd.
publishDate	2020
url	https://doaj.org/article/361d893421ce4eee888e30d73f73109c
work_keys_str_mv	AT jamesgnaples endoscopicsinussurgeryandaspirindesensitizationimproveotologicspecificsnot22scores AT andrewcorr endoscopicsinussurgeryandaspirindesensitizationimproveotologicspecificsnot22scores AT siddhanttripathi endoscopicsinussurgeryandaspirindesensitizationimproveotologicspecificsnot22scores AT morganberman endoscopicsinussurgeryandaspirindesensitizationimproveotologicspecificsnot22scores AT jasonabrant endoscopicsinussurgeryandaspirindesensitizationimproveotologicspecificsnot22scores AT michaeljruckenstein endoscopicsinussurgeryandaspirindesensitizationimproveotologicspecificsnot22scores AT johnbosso endoscopicsinussurgeryandaspirindesensitizationimproveotologicspecificsnot22scores
_version_	1718378501997854720

Endoscopic sinus surgery and aspirin desensitization improve otologic-specific SNOT-22 scores

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