Antinuclear antibodies produced in HLA-DR transgenic humanized mice developed chronic graft-versus-host disease

Antinuclear antibodies produced in HLA-DR transgenic humanized mice developed chronic graft-versus-host disease

Background: Chronic graft versus host disease (GVHD) has been reported in humanized mice after the implantation of human hematopoietic stem cells (hu-HSC). As such, humanized mice have been applied to a mouse model of chronic GVHD; however, B-cell activation and autoantibody production did not occur...

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Autores principales: Hiroshi Tsuzuki, Yasuko Nagatsuka, Mitsuhiro Iwata, Noboru Kitamura, Yosuke Nagasawa, Taro Matsumoto, Ryoji Ito, Takeshi Takahashi, Mamoru Ito, Hideki Nakamura, Masami Takei
Formato: article
Lenguaje:EN
Publicado: Elsevier 2021
Materias:
Chronic GVHD
HLA-DR transgenic humanized mouse
Autoantibody
Antinuclear antibody
Science (General)
Q1-390
Social sciences (General)
H1-99
Acceso en línea:https://doaj.org/article/361f156e4513435d8a376822ce89304e
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