Rational Design of Peptide-based Smart Hydrogels for Therapeutic Applications

Peptide-based hydrogels have captivated remarkable attention in recent times and serve as an excellent platform for biomedical applications owing to the impressive amalgamation of unique properties such as biocompatibility, biodegradability, easily tunable hydrophilicity/hydrophobicity, modular inco...

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Autores principales: Saurav Das, Debapratim Das
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Lenguaje:EN
Publicado: Frontiers Media S.A. 2021
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spelling oai:doaj.org-article:3621e40316df44528bb4642e01d284da2021-11-16T07:12:28ZRational Design of Peptide-based Smart Hydrogels for Therapeutic Applications2296-264610.3389/fchem.2021.770102https://doaj.org/article/3621e40316df44528bb4642e01d284da2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fchem.2021.770102/fullhttps://doaj.org/toc/2296-2646Peptide-based hydrogels have captivated remarkable attention in recent times and serve as an excellent platform for biomedical applications owing to the impressive amalgamation of unique properties such as biocompatibility, biodegradability, easily tunable hydrophilicity/hydrophobicity, modular incorporation of stimuli sensitivity and other functionalities, adjustable mechanical stiffness/rigidity and close mimicry to biological molecules. Putting all these on the same plate offers smart soft materials that can be used for tissue engineering, drug delivery, 3D bioprinting, wound healing to name a few. A plethora of work has been accomplished and a significant progress has been realized using these peptide-based platforms. However, designing hydrogelators with the desired functionalities and their self-assembled nanostructures is still highly serendipitous in nature and thus a roadmap providing guidelines toward designing and preparing these soft-materials and applying them for a desired goal is a pressing need of the hour. This review aims to provide a concise outline for that purpose and the design principles of peptide-based hydrogels along with their potential for biomedical applications are discussed with the help of selected recent reports.Saurav DasDebapratim DasFrontiers Media S.A.articlepeptidehydrogeldrug deliverytissue engineeringself-assemblystimuli responsiveChemistryQD1-999ENFrontiers in Chemistry, Vol 9 (2021)
institution DOAJ
collection DOAJ
language EN
topic peptide
hydrogel
drug delivery
tissue engineering
self-assembly
stimuli responsive
Chemistry
QD1-999
spellingShingle peptide
hydrogel
drug delivery
tissue engineering
self-assembly
stimuli responsive
Chemistry
QD1-999
Saurav Das
Debapratim Das
Rational Design of Peptide-based Smart Hydrogels for Therapeutic Applications
description Peptide-based hydrogels have captivated remarkable attention in recent times and serve as an excellent platform for biomedical applications owing to the impressive amalgamation of unique properties such as biocompatibility, biodegradability, easily tunable hydrophilicity/hydrophobicity, modular incorporation of stimuli sensitivity and other functionalities, adjustable mechanical stiffness/rigidity and close mimicry to biological molecules. Putting all these on the same plate offers smart soft materials that can be used for tissue engineering, drug delivery, 3D bioprinting, wound healing to name a few. A plethora of work has been accomplished and a significant progress has been realized using these peptide-based platforms. However, designing hydrogelators with the desired functionalities and their self-assembled nanostructures is still highly serendipitous in nature and thus a roadmap providing guidelines toward designing and preparing these soft-materials and applying them for a desired goal is a pressing need of the hour. This review aims to provide a concise outline for that purpose and the design principles of peptide-based hydrogels along with their potential for biomedical applications are discussed with the help of selected recent reports.
format article
author Saurav Das
Debapratim Das
author_facet Saurav Das
Debapratim Das
author_sort Saurav Das
title Rational Design of Peptide-based Smart Hydrogels for Therapeutic Applications
title_short Rational Design of Peptide-based Smart Hydrogels for Therapeutic Applications
title_full Rational Design of Peptide-based Smart Hydrogels for Therapeutic Applications
title_fullStr Rational Design of Peptide-based Smart Hydrogels for Therapeutic Applications
title_full_unstemmed Rational Design of Peptide-based Smart Hydrogels for Therapeutic Applications
title_sort rational design of peptide-based smart hydrogels for therapeutic applications
publisher Frontiers Media S.A.
publishDate 2021
url https://doaj.org/article/3621e40316df44528bb4642e01d284da
work_keys_str_mv AT sauravdas rationaldesignofpeptidebasedsmarthydrogelsfortherapeuticapplications
AT debapratimdas rationaldesignofpeptidebasedsmarthydrogelsfortherapeuticapplications
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