A synthetic circuit for buffering gene dosage variation between individual mammalian cells

Transient plasmid transfection produces a wide distribution of copy numbers and expression heterogeneity. Here the authors present synthetic circuits called Equalizers that buffer copy number variation at the single-cell level and minimize cell-to-cell expression variability.

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Autores principales:	Jin Yang, Jihwan Lee, Michelle A. Land, Shujuan Lai, Oleg A. Igoshin, François St-Pierre
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3624485f7c5c49edb625fe43b2b5f8d9
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spelling	oai:doaj.org-article:3624485f7c5c49edb625fe43b2b5f8d92021-12-02T15:23:10ZA synthetic circuit for buffering gene dosage variation between individual mammalian cells10.1038/s41467-021-23889-02041-1723https://doaj.org/article/3624485f7c5c49edb625fe43b2b5f8d92021-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23889-0https://doaj.org/toc/2041-1723Transient plasmid transfection produces a wide distribution of copy numbers and expression heterogeneity. Here the authors present synthetic circuits called Equalizers that buffer copy number variation at the single-cell level and minimize cell-to-cell expression variability.Jin YangJihwan LeeMichelle A. LandShujuan LaiOleg A. IgoshinFrançois St-PierreNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jin Yang Jihwan Lee Michelle A. Land Shujuan Lai Oleg A. Igoshin François St-Pierre A synthetic circuit for buffering gene dosage variation between individual mammalian cells
description	Transient plasmid transfection produces a wide distribution of copy numbers and expression heterogeneity. Here the authors present synthetic circuits called Equalizers that buffer copy number variation at the single-cell level and minimize cell-to-cell expression variability.
format	article
author	Jin Yang Jihwan Lee Michelle A. Land Shujuan Lai Oleg A. Igoshin François St-Pierre
author_facet	Jin Yang Jihwan Lee Michelle A. Land Shujuan Lai Oleg A. Igoshin François St-Pierre
author_sort	Jin Yang
title	A synthetic circuit for buffering gene dosage variation between individual mammalian cells
title_short	A synthetic circuit for buffering gene dosage variation between individual mammalian cells
title_full	A synthetic circuit for buffering gene dosage variation between individual mammalian cells
title_fullStr	A synthetic circuit for buffering gene dosage variation between individual mammalian cells
title_full_unstemmed	A synthetic circuit for buffering gene dosage variation between individual mammalian cells
title_sort	synthetic circuit for buffering gene dosage variation between individual mammalian cells
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/3624485f7c5c49edb625fe43b2b5f8d9
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A synthetic circuit for buffering gene dosage variation between individual mammalian cells

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