A synthetic circuit for buffering gene dosage variation between individual mammalian cells
Transient plasmid transfection produces a wide distribution of copy numbers and expression heterogeneity. Here the authors present synthetic circuits called Equalizers that buffer copy number variation at the single-cell level and minimize cell-to-cell expression variability.
Guardado en:
Autores principales: | Jin Yang, Jihwan Lee, Michelle A. Land, Shujuan Lai, Oleg A. Igoshin, François St-Pierre |
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Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2021
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Materias: | |
Acceso en línea: | https://doaj.org/article/3624485f7c5c49edb625fe43b2b5f8d9 |
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